A5041295887- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Nutrition and Health in Aging
- Dementia and Cognitive Impairment Research
- Health disparities and outcomes
- Health, Environment, Cognitive Aging
- Chronic Disease Management Strategies
- Cerebral Palsy and Movement Disorders
- COVID-19 and Mental Health
- Balance, Gait, and Falls Prevention
- Older Adults Driving Studies
- Psychological Well-being and Life Satisfaction
- Birth, Development, and Health
- Geriatric Care and Nursing Homes
- Alcoholism and Thiamine Deficiency
- Diet and metabolism studies
- Technology Use by Older Adults
- Telemedicine and Telehealth Implementation
- Energy and Environment Impacts
- Global Health Care Issues
- Urban Green Space and Health
- Memory Processes and Influences
- Alcohol Consumption and Health Effects
- Functional Brain Connectivity Studies
- COVID-19 impact on air quality
University of Edinburgh
2017-2025
Alzheimer Scotland
2021-2025
NHS Lothian
2020-2022
The COVID-19 pandemic has affected many aspects of people's lives. Lockdown measures to reduce the spread have been more stringent for those aged over 70, at highest risk disease. Here, we examine whether home garden usage is associated with self-reported mental and physical wellbeing in older adults, during lockdown Scotland. This study analysed data from 171 individuals (mean age 84 ± 0.5 years) Lothian Birth Cohort 1936 who completed an online survey approximately two months after...
(1) Objectives: The COVID-19 pandemic has disproportionately affected the lives of older people. In this study, we examine changes in physical activity, sleep quality, and psychosocial variables among people during lockdown. We build on cross-sectional studies topic by assessing change longitudinally. also examined whether participant characteristics including demographic, cognitive, personality, health were related to more positive or negative (2) Methods: 137 participants (mean age 84...
Research suggests that frailty is associated with higher inflammation levels. We investigated the longitudinal association between chronic and progression.Participants of Lothian Birth Cohort 1936, aged 70 at baseline were tested four times over 12 years (wave 1: n = 1091, wave 4: 550). Frailty was assessed by; Index waves 1-4 Fried phenotype 1, 3 4. Two blood-based inflammatory biomarkers measured Fibrinogen C-reactive protein (CRP).Fully-adjusted, linear mixed effects models showed...
Abstract Background Age-related changes in frailty have been documented the literature. However, evidence regarding prior to death is scarce. Understanding patterns of progression as individuals approach could inform care and potentially lead interventions improve individual’s well-being at end life. In this paper, we estimate years death. Methods Using data from 8,317 deceased participants Survey Health, Ageing, Retirement Europe, derived a 56-item Frailty Index. coordinated analysis...
Frailty is a complex trait. Twin studies and high-powered Genome Wide Association Studies conducted in the UK Biobank have demonstrated strong genetic basis of frailty. The present study utilized summary statistics from Study on Index to create test predictive power frailty polygenic risk scores (PRS) two independent samples - Lothian Birth Cohort 1936 (LBC1936) English Longitudinal Ageing (ELSA) aged 67-84 years. Multiple regression models were built PRS at five time points. significantly...
Little is known about effects of COVID-19 lockdown on psychosocial factors, health and lifestyle in older adults, particularly those aged over 80 years, despite the risks posed by to this age group.
There is an urgent need to better understand frailty and its predisposing factors. Although numerous cross-sectional studies have identified various risk protective factors of frailty, there a limited understanding longitudinal progression. Furthermore, discrepancies in the methodologies these hamper comparability results. Here, we use coordinated analytical approach 5 independent cohorts evaluate trajectories effect 3 previously critical factors: sex, age, education.We derived index (FI)...
Abstract Objectives Motoric Cognitive Risk (MCR) is a gait‐based predementia syndrome that easy to measure and prognostic of dementia falls. We aimed examine the prevalence risk factors for MCR, assess its overlap with Mild Impairment, Prefrailty, Frailty, in cohort older Scottish adults without dementia. Methods In this longitudinal prospective study, we classified 690 participants (mean [SD] age 76.3 [0.8] years; wave 3) Lothian Birth Cohort 1936 (LBC1936) into non‐MCR or MCR groups....
Mild cognitive impairment (MCI) describes a borderland between healthy cognition and dementia. Progression to reversion from MCI is relatively common but more research required understand the factors affecting this fluidity improve clinical care interventions.We explore these transitions in status their predictive over six-year period highly-phenotyped longitudinal study, Lothian Birth Cohort 1936.MCI was derived LBC1936 at ages 76 (n = 567) 82 years 341) using NIA-AA diagnostic guidelines....
Neighborhood features have been postulated to be key predictors of frailty. However, evidence is mainly limited cross-sectional studies without indication long-term impact. We explored how neighborhood social deprivation (NSD) across the life course associated with frailty and progression among older Scottish adults. Participants (n = 323) were persons selected from Lothian Birth Cohort 1936 historical measures NSD in childhood (1936-1955), young adulthood (1956-1975), mid- late (1976-2014)....
Background: The Lothian Birth Cohort 1936 (LBC1936) is a highly phenotyped longitudinal study of cognitive and brain ageing. Given its substantial clinical importance, we derived an indicator mild impairment (MCI) amnestic nonamnestic subtypes at 3 time points. Methods: MCI status was waves the LBC1936 ages 76 (n=567), 79 (n=441), 82 years (n=341). A general category as well (aMCI) (naMCI). comparison made between derivations using normative data from cohort versus UK population. Results:...
<b><i>Introduction:</i></b> Recent research suggests that the experience of frailty progression may be heterogeneous, with latent subpopulations older adults following distinct trajectories frailty. We aimed to investigate this notion and determine whether certain factors are associated membership these subpopulations. <b><i>Methods:</i></b> Data from 5 data waves collected over 12 years in participants Lothian Birth Cohort 1936, aged 70 at...
Introduction Digital cognitive assessments are gathering importance for the decentralized remote clinical trials of future. Before including such in trials, they must be tested to confirm feasibility and acceptability with intended participant group. This study presents usability data from Speech on Phone Assessment (SPeAk) study. Methods Participants ( N = 68, mean age 70.43 years, 52.9% male) provided demographic completed baseline 3-month follow-up phone based assessments. The visit was...
Abstract Frailty is a complex trait. Twin studies and recent Genome-Wide Association Studies have demonstrated strong genetic basis of frailty but there remains lack exploring prediction Frailty. Previous work has shown that single polygenic predictor – represented by score - predicts Frailty, measured via the index, in independent samples within United Kingdom. We extended this work, using multi-polygenic (MPS) approach to increase predictive power. Predictor variables twenty-six scores...
Abstract Background Recent therapeutic successes in the treatment of Alzheimer’s disease (AD), and diagnostic tools such as blood‐based biomarkers, have energised field to develop more specific diagnostics therapies following best principles precision medicine. Large, ‘real‐world’ cohorts are needed understand whether these, other future breakthroughs, valid when employed wider AD community. Methods Our cohort study will provide a well‐phenotyped (combining data on risk factors for...
Frailty is a complex trait. Twin studies and high-powered Genome Wide Association Study (GWAS) conducted in the UK Biobank have demonstrated strong genetic basis of frailty. The present study utilized summary statistics from this GWAS to create test predictive power frailty polygenic risk scores (PRS) two independent samples - Lothian Birth Cohort 1936 (LBC1936) English Longitudinal Ageing (ELSA) aged 67-84 years. Multiple regression models were built PRS at five time points. significantly...
ABSTRACT Background The Lothian Birth Cohort 1936 (LBC1936) is a highly-phenotyped longitudinal study of cognitive and brain ageing. Given its substantial clinical importance, we derived an indicator mild impairment (MCI) as well amnestic non-amnestic subtypes at three time points. Methods MCI status was waves the LBC1936 ages 76 ( n =567), 79 =441), 82 years =341). A general category (aMCI) (naMCI). comparison made between derivations using normative data from cohort versus UK population....
ABSTRACT Background Little is known about effects of COVID-19 lockdown on psychosocial factors, health and lifestyle in older adults, particularly those aged over 80 years, despite the risks posed by to this age group. Methods Lothian Birth Cohort 1936 members, mean 84 years (SD=0.3), responded an online questionnaire May 2020 ( n =190). We examined responses (experience knowledge COVID-19; adherence guidance; impact day-to-day living; social contact; self-reported physical mental health;...