A5053917452- Hepatitis C virus research
- Hepatitis B Virus Studies
- HIV Research and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Monoclonal and Polyclonal Antibodies Research
Karolinska University Hospital
2013-2017
Karolinska Institutet
2013-2017
Clearance of infections caused by the hepatitis C virus (HCV) correlates with HCV-specific T cell function. We therefore evaluated therapeutic vaccination in 12 patients chronic HCV infection. Eight also underwent a subsequent standard-of-care (SOC) therapy pegylated interferon (IFN) and ribavirin. The phase I/IIa clinical trial was performed treatment naive genotype 1 patients, receiving four monthly vaccinations deltoid muscles 167, 500, or 1,500 μg codon-optimized nonstructural (NS)...
Human hepatitis B virus (HBV) core antigen (HBcAg) can act as an adjuvant in C (HCV)-based DNA vaccines. Since two billion people are, or have been, contact with HBV, one may question the use of human HBV sequences adjuvant. We herein evaluated non-human stork gene-sequences from vaccine adjuvants. Full-length and fragmented HBcAg were added to HCV non-structural (NS) 3/4A gene (NS3/4A-stork-HBcAg). This resulted enhanced priming HCV-specific IFN-γ IL-2 responses both wild-type (wt)-...
Objective HCV is characterised by its ability to establish chronic infection in hepatocytes and replicate the presence of an inflammation. We mimicked this situation vivo immune-competent mice syngeneic transplantation replicon-containing mouse hepatoma cells. Design A total 5 million H-2 b positive Hep56.1D cells, carrying a subgenomic genotype (gt) 2a replicon (HCV cells) or stably expressing comparable levels NS3/4A protease/helicase complex (NS3/4A cells), were injected subcutaneously...