Abstract Melioidosis, which is often referred to as Whitmore’s illness, a potentially fatal infection that arises from the environmental Gram-negative bacillus Burkholderia pseudomallei . These bacteria can have fatality rate of up 40% and are typically characterized by numerous abscesses pneumonia. Functional neutrophil defects, linked risk factors like diabetes, may significantly contribute pathophysiology melioidosis. Research has identified virulence factor, such type III secretion...

Purpose: Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are a major public health concern due to their recurrent nature and antibiotic resistance. Biofilm formation plays crucial role in UPEC persistence, yet the genetic mechanisms underlying this process remain poorly understood. This study employs next-generation sequencing (NGS) investigate genomic characteristics of biofilm-forming, multidrug-resistant (MDR) isolates, with focus on antimicrobial...

Certain genetically defined undifferentiated round cell sarcomas, namely BCOR-CCNB3 and CIC-DUX4 positive, have been described. Here we present detailed clinicopathologic features molecular results in such cases.Fifty one cases of including 32 cases, tested for fusions, by reverse transcription polymerase chain reaction technique 44 tumours, CCNB3 immunostaining, were analyzed.Twenty seven (52.9%) tumours occurred males 24 (47%) females; soft tissues (38; 74.5%), commonly, trunk extremities...

Background: Sepsis is one of the commonest cause neonatal mortality. The aetiology sepsis has variations according to various customs and practices in perinatal period geographical area. This study was designed analyse magnitude aetiological characteristics & also antibiotic sensitivity pattern isolates. Methods: prospective conducted Department Microbiology including 250 neonates with suspected admitted Dept. Paediatrics NICU, Kalinga Institute Medical Sciences (KIMS), Bhubaneswar, during...

Background: Nosocomial infection, due to Candida, contracted in the pediatric intensive care unit (PICU), is emerging as a significant healthcare challenge. The incidence of non-albicans Candida cause candidemia on rise, unlike previous decades. Materials and Methods: All cases confirmed by culture, admitted PICU during study period January 2017 December 2019, were retrospectively studied. prevalence, speciation, sensitivity pattern risk factors mortality recorded analyzed. Results: There...

Background: Pseudomonas aeruginosa is a clinically troublesome gram-negative pathogen that causes both opportunistic infections and nosocomial outbreaks. Metallo beta lactamase have recently emerged as worrisome resistance mechanism. Carbapenems had been the drug of choice for caused by most penicillin- or cephalosporin-resistant bacteria due to its broad-spectrum activity stability hydrolysis beta-lactamases. This does not hold good anymore rapid uprise MBL producing strains. The current...

Certain undifferentiated round cell sarcomas characterised by specific underlying genetic fusions have been reported. This case describes cytomorphological and corresponding histopathological, including immunohistochemical features of a rare CIC‐DUX4 positive sarcoma, literature review similar reported cases.

A variety of infectious diseases can have clinical, radiological and histopathological findings that mimic various malignancies. We report a case 53 year old immunocompetent man admitted initially as perforation peritonitis with strong clinical suspicion gastric malignancy. Histologically, the biopsy from stomach site showed necrotic wall scattered atypical cells in muscularis. Initially suspected to be neoplastic, these could not characterized definitively by an immunohistochemistry panel....

Pyogenic Liver Abscess (PLA) is an uncommon disease with annual incidence rate ranging from 2 to 45 cases per 100000 hospital admissions worldwide.Gas-Forming (GFPLA) even rarer, which accounts for 7% 24% of PLA and associated a high mortality in spite aggressive management. It commonly underlying immunosuppression like diabetes mellitus. Gas formation occurs as result mixed acid fermentation within the abscess by formic hydrogenlyase, enzyme produced certain bacteria. Common presentations...

Background: Urinary tract infection (UTI) is one of the common infections encountered by clinicians.Though a good number antimicrobial agents are available, still UTIs have become difficult to treat due development resistance uropathogens.So regional data regarding uropathogens and their sensitivity pattern required guide clinicians start empiric therapy while managing UTIs.Objectives: The aim objective this study was detect organisms causing community acquired UTI in our region which part...

Abstract Introduction: Biomarkers predictive of response to mechanistic target rapamycin (mTOR) inhibitor, everolimus, in endocrine receptor (ER)-positive metastatic breast cancer (MBC) are a work progress. We evaluated the feasibility directly measuring mTOR activity and phosphatase tensin homolog (PTEN) expression correlating their with survival. Materials Methods: MBC patients who received everolimus therapy (ET) after progression on an aromatase inhibitor had adequate tissue preservation...

e19012 Background: AIDS related non Hodgkin’s Lymphoma (ARL) remains a major cause of morbidity and mortality .There are limited prospective studies on ARLs in Indian population. We studied the clinical profile outcome patients with ARL . Methods: Consecutive diagnosed period February 2014-march 2016 who were treatment naïve included study. Details HIV ARL, details , complications recorded. The primary objective was overall survival(OS), secondary objectives response rates correlation...

Typhoid fever is considered as one of the most serious infectious disease and threat to public health on a global scale, especially in developing countries, with particular concern over rapid widespread emergence resistant Salmonella Typhi multiple antibiotics. Hence it becomes imperative assess extent drug resistance before treatment administered. Present study was aimed analyze profile typhoid fever, its different complications antibiotic sensitivity pattern tertiary care setting. A...

Background: Neonatal septicaemia is characterized by systemic signs and symptoms of generalized bacteraemia with a positive blood culture in the first four weeks life. This study was designed to detect Multi Drug Resistant pattern from organisms neonatal septicaemic cases. The aim find antibiotic sensitivity drug resistance (ESBL, MBL, Carbapenemase, AmpC β-lactamase, MRSA) among isolated. Methods: prospective carried out Department Microbiology association Dept. Paediatrics NICU, Kalinga...

Background: Neonatal sepsis is the third leading cause of neonatal mortality and a major public health problem, especially in developing countries. In countries being responsible for 30-50% 5 million total deaths each year. The detection microorganisms patient's blood has great diagnostic prognostic significance. Blood cultures provide essential information evaluation variety diseases like endocarditis, pneumonia, pyrexia unknown origin particularly patients with suspected sepsis. our study...

R.gilardii is a pink gram-negative coccobacillus belonging to the genus Roseomonas. Here we are going discuss about case which presented as acute febrile illness. Roseomonas gilardii has been isolated from blood specimen of patient. She treated with Amikacin referring previous literature1 . The patient started recovering and was discharged in recovery phase.