A5101779465- Extracellular vesicles in disease
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
- Receptor Mechanisms and Signaling
- Advanced biosensing and bioanalysis techniques
- Crustacean biology and ecology
- Ion channel regulation and function
- Surfactants and Colloidal Systems
- RNA regulation and disease
- Blood properties and coagulation
- Pregnancy and preeclampsia studies
- Insect Utilization and Effects
- Viral Infectious Diseases and Gene Expression in Insects
- Pigment Synthesis and Properties
- Perovskite Materials and Applications
- Material Properties and Applications
- Circular RNAs in diseases
- RNA and protein synthesis mechanisms
- Nicotinic Acetylcholine Receptors Study
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Mechanical Circulatory Support Devices
- RNA modifications and cancer
- Advanced battery technologies research
- Advanced Battery Materials and Technologies
Huazhong University of Science and Technology
2009-2024
Union Hospital
2024
Yale University
2017-2023
Jilin University
2022
Nantong University
2020-2021
Sichuan University
2020
Washington State University
2017
Shinshu University
1997
Abstract Serum small extracellular vesicles (sEVs) have recently drawn considerable interest because of the diagnostic and therapeutic potential their miRNAs content. However, characteristics human, mouse rat serum sEVs differences in RNA contents are still unknown. In this study, through nanoparticle tracking analysis sequencing, we found that rat, exhibited distinct sizes particle numbers as well contents. contained not only abundant but also a large number tRNA fragments. Most existed...
Sensitive assay and imaging of multiple low-abundance microRNAs (miRNAs) in living cells remain a grand challenge. Herein, based on polyelectrolyte-induced reduction, facile approach has been proposed to synthesize novel MnO2 nanotubes. Owing the remarkably strong fluorescence quenching ability, low cytotoxicity, excellent colloid stability, as-prepared nanotubes showed great potential for simultaneous detection miRNAs vitro situ first time. Besides, can be reduced Mn2+ by intracellular acid...
Transmembrane domains (TMDs) engage in protein-protein interactions that regulate many cellular processes, but the rules governing specificity of these are poorly understood. To discover principles, we analyzed 26-residue model transmembrane proteins consisting exclusively leucine and isoleucine (called LIL traptamers) specifically activate erythropoietin receptor (EPOR) mouse cells to confer growth factor independence. We discovered placement a single side chain methyl group at specific...
Transmembrane (TM) domains as simple a single span can perform complex biological functions using entirely lipid-embedded chemical features. Computational design has potential to generate custom tool molecules directly targeting membrane proteins at their functional TM regions. Thus far, designed domain-targeting agents have been limited mimicking binding modes and motifs of natural interaction partners. Here, we demonstrate the de novo erythropoietin receptor (EpoR) domain in topology...
Serum small extracellular vesicles (sEVs) and their RNA (sRNA) cargoes could be promising biomarkers for the diagnosis of liver injury. However, dynamic changes in serum sEVs sRNA components during injury have not been well characterized. Given that hepatic macrophages can quickly clear intravenously injected sEVs, effect injury-related on deserves to explored.To identify characteristics sRNAs explore effects macrophages.To sEV injury, we established a CCL4-induced mouse model C57BL/6 mice...