A5064691316- CRISPR and Genetic Engineering
- Mesenchymal stem cell research
- Hematopoietic Stem Cell Transplantation
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Pluripotent Stem Cells Research
- Glycosylation and Glycoproteins Research
- Carbohydrate Chemistry and Synthesis
- Tissue Engineering and Regenerative Medicine
- Erythrocyte Function and Pathophysiology
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Electrospun Nanofibers in Biomedical Applications
- Transplantation: Methods and Outcomes
- Cancer Cells and Metastasis
- Bone Tissue Engineering Materials
Lund University
2020-2025
Wallenberg Wood Science Center
2024-2025
New England Biolabs (United States)
2023
Design criteria for tissue-engineered materials in regenerative medicine include robust biological effectiveness, off-the-shelf availability, and scalable manufacturing under standardized conditions. For bone repair, existing strategies rely on primary autologous cells, associated with unpredictable performance, limited availability complex logistic. Here, a conceptual shift based the of devitalized human hypertrophic cartilage (HyC), as cell-free material inducing formation by...
N-glycosylation is implicated in cancers and aberrant recognized as a hallmark of cancer. Here, we mapped compared the site-specific N-glycoproteomes colon cancer HCT116 cells isogenic non-tumorigenic DNMT1/3b double knockout (DKO1) using Fbs1-GYR N-glycopeptide enrichment technology trapped ion mobility spectrometry. Many significant changes were revealed, providing molecular basis for further elucidation role protein function. display hypersialylation especially cell surface membrane...
Within the bone marrow (BM), intercellular communication between hematopoietic stem and progenitor cells (HSPCs) mesenchymal stem/stromal (MSCs) is critical for life-long maintenance of functional hematopoiesis. In recent years, transfer mitochondria MSCs HSPCs has emerged as a key aspect this communication, occurring both in stress homeostatic conditions. human, mesenchymal-to-hematopoietic process impact remain cryptic, primarily due to lack robust models. To end, we here describe...
Tissue engineering strategies predominantly rely on the production of living substitutes, whereby implanted cells actively participate in regenerative process. Beyond cost and delayed graft availability, patient-specific performance engineered tissues poses serious concerns their clinical translation ability. A more exciting paradigm consists exploiting cell-laid, extracellular matrices (eECM), which can be used as off-the-shelf materials. Here, capacity solely relies preservation eECM...
Tissue engineering strategies predominantly rely on the production of living substitutes, whereby implanted cells actively participate in regenerative process. Beyond cost and delayed graft availability, patient-specific performance engineered tissues poses serious concerns their clinical translation ability. A more exciting paradigm consists exploiting cell-laid, extracellular matrices (eECMs), which can be used as off-the-shelf materials. Here, capacity solely relies preservation eECM...
Faithful modeling of tissues and organs requires the development systems reflecting their dynamic 3D cellular architecture organization. Current technologies suffer from a lack design flexibility complex prototyping, preventing broad adoption by scientific community. To make cell culture more available adaptable we here describe use fused deposition (FDM) technology to rapid-prototype printed perfusion bioreactors. Our bioreactors are made polylactic acid resulting in reusable customizable...
The bone marrow microenvironment provides indispensable factors to sustain blood production throughout life. It is also a hotspot for the progression of hematologic disorders and most frequent site solid tumor metastasis. Preclinical research relies on xenograft mouse models, but these models preclude human-specific functional interactions stem cells with their microenvironment. Instead, human mesenchymal can be exploited in vivo engineering humanized niches, which confer robust engraftment...
Tissue engineering strategies predominantly rely on the production of living substitutes, whereby implanted cells actively participate in regenerative process. Beyond cost and delayed graft availability, patient-specific performance engineered tissues poses serious concerns their clinical translation ability. A more exciting paradigm consists exploiting cell-laid, extracellular matrices (eECM), which can be used as off-the-shelf materials. Here, capacity solely relies preservation eECM...
Tissue engineering strategies predominantly rely on the production of living substitutes, whereby implanted cells actively participate in regenerative process. Beyond cost and delayed graft availability, patient-specific performance engineered tissues poses serious concerns their clinical translation ability. A more exciting paradigm consist exploiting cell-laid, extracellular matrices (eECM), which can be used as off-the-shelf materials. Here, capacity solely relies preservation eECM...
Abstract Tissue engineering strategies predominantly rely on the production of living substitutes, whereby implanted cells actively participate in regenerative process. Beyond cost and delayed graft availability, patient-specific performance engineered tissues poses serious concerns their clinical translation ability. A more exciting paradigm consists exploiting cell-laid, extracellular matrices (eECM), which can be used as off-the-shelf materials. Here, capacity solely relies preservation...
Abstract N-glycoproteomic analyses provide valuable resources for investigation of cancer mechanisms, biomarkers, and therapeutic targets. Here, we mapped compared the site-specific N-glycoproteomes colon HCT116 cells isogenic non-tumorigenic DNMT1/3b double knockout (DKO1) using Fbs1-GYR N-glycopeptide enrichment technology trapped ion mobility spectrometry. Many significant changes in N-glycosylation were revealed, providing a molecular basis further elucidation role protein function....