A5083165747- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Nitric Oxide and Endothelin Effects
- Urticaria and Related Conditions
- Heme Oxygenase-1 and Carbon Monoxide
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Autoimmune Bullous Skin Diseases
- Aldose Reductase and Taurine
University of Lübeck
2012-2013
Institute of Medical Microbiology and Hygiene
2013
Leipzig University
2009
The formation of neutrophil extracellular traps (NETs) depends on the generation reactive oxygen species (ROS). Previous studies revealed that both NADPH oxidase and myeloperoxidase (MPO) are required for NET release. However, contribution various ROS as well role mitochondria-derived has not been addressed so far. In present study we aimed to investigate in a systematic comprehensive manner ROS-generating pathways PMA-induced By using specific inhibitors, oxidase- superoxide dismutase (SOD)...
Neutrophil extracellular traps (NETs) have been suggested to play a pathophysiological role in several autoimmune diseases. Since NET-formation response biological and chemical stimuli is mostly ROS dependent, theory any substance that inhibits or scavenges could prevent ROS-dependent NET release. Therefore, the present comprehensive study, antioxidative substances were assessed for their capacity inhibit formation of primary human neutrophils vitro . We show flavonoids (−)-epicatechin,...