A5087248590- Sesquiterpenes and Asteraceae Studies
- Cancer Treatment and Pharmacology
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Bone Tissue Engineering Materials
- Nanocluster Synthesis and Applications
- Organic Light-Emitting Diodes Research
- Plant-derived Lignans Synthesis and Bioactivity
- Cancer therapeutics and mechanisms
- Chemotherapy-induced cardiotoxicity and mitigation
- Synthesis and Reactions of Organic Compounds
- 3D Printing in Biomedical Research
- Nanoparticle-Based Drug Delivery
- Synthesis and Biological Evaluation
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- DNA Repair Mechanisms
- Lanthanide and Transition Metal Complexes
- Synthetic Organic Chemistry Methods
- Graphene and Nanomaterials Applications
Institute of Physiologically Active Compounds
2021-2025
Chemotherapy with anthracycline antibiotics is a common method of treating tumors various etiologies. To create more highly effective cytostatics based on daunorubicin, we used the reductive amination using polyalkoxybenzaldehydes. The obtained derivatives structure have much greater cytotoxicity compared to daunorubicin due increased affinity for DNA, ability disrupt cell cycle, and their inhibition glycolysis process, which confirmed by data from extensive biological studies results...
Abstract Rare‐earth element‐free materials that exhibit strong room temperature phosphorescence (RTP) and X‐ray scintillation properties are gaining global interest incessantly in the recent years. This work reports a series of easily synthesizable cubane Cu 4 I ‐triarsenic clusters [Cu (R 3 As) L] (L = none or nitrile), yellow‐green RTP with quantum efficiencies up to 100% short decay times (4.4–4.9 µs). The title cluster complexes display record ultralow detection limit (18.1 nGy s −1 )...
We present the results of a histological study into cardiotoxicity conjugates daunorubicin with dehydrocostus lactone and epoxyisoalantolactone in mature male mice C57BL/6 line. The effect on morphology cardiomyocytes structure left ventricular myocardium was studied.
Abstract New conjugates of daunorubicin with sesquiterpene lactones at the 3′‐amino group anthracycline were synthesized and their effect on viability cell lines (HL60, Jurkat, K562, A549) was assessed using a resazurin test. The cycle apoptosis by flow cytometry studied. following natural used for modification: telekin, isotelekin, reynosin, costunolide, dehydrocostuslactone, santamarine epoxyisoalantolactone. are characterized general high toxicity (8…0.14 μM) in relation to tumor (in some...
Cell culturing methods in its classical 2D approach have limitations associated with altered cell morphology, gene expression patterns, migration, cycle and proliferation. Moreover, high throughput drug screening is mainly performed on cultures which are physiologically far from proper functions resulting inadequate hit-compounds subsequently fail. A shift to 3D protocols could solve issues biochemistry signaling would lead a recapitulation of physiological conditions test systems. Here, we...
Abstract Chemotherapy with anthracycline antibiotics is a common treatment of tumours various etiologies. Creation highly effective cytostatics based on daunorubicin possible by applying the method reductive amination using polyalkoxybenzaldehydes. The obtained derivatives structure are up to 500 times more potent compared due increased affinity DNA, which confirmed data extensive biological assays and results molecular modeling.
New derivatives of pyrano[3,2-c]pyridones III 5, 10, 15, 18 were synthesised by threecomponent reaction pyridonotryptamines I, aromatic aldehydes II and malononitril. Pyridonotryptamines I tryptamines (these compounds obtained Grandberg arylhydrazines with γ-halogencarbonyl compounds) 4-hydroxy- 6-methyl-2H-pyran- 2-on. The 1, 6, 9 are commercially available compounds. Boiling a mixture malononitril (molar ratio 1:1.1:1.1) in ethyl alcohol the presence triethylamine gives target 18. product...