A5071846636- Sesquiterpenes and Asteraceae Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Plant Toxicity and Pharmacological Properties
- Natural product bioactivities and synthesis
- Marine Sponges and Natural Products
- Synthesis of Organic Compounds
- Synthetic Organic Chemistry Methods
- Cancer Treatment and Pharmacology
- Metal complexes synthesis and properties
- Bioactive Compounds and Antitumor Agents
- Synthesis and Reactions of Organic Compounds
- Synthesis and Biological Evaluation
- Quinazolinone synthesis and applications
- Chemical synthesis and alkaloids
- Synthesis of heterocyclic compounds
- Cholinesterase and Neurodegenerative Diseases
- Histone Deacetylase Inhibitors Research
- Crystal structures of chemical compounds
- Computational Drug Discovery Methods
- Biological Activity of Diterpenoids and Biflavonoids
- Photodynamic Therapy Research Studies
- Porphyrin and Phthalocyanine Chemistry
Institute of Physiologically Active Compounds
2015-2025
Pirogov Russian National Research Medical University
2025
Scientific Center of RAS in Chernogolovka
2021
Russian Academy of Sciences
2012-2021
A N Bach Institute of Biochemistry
2020
Artemisinin is a sesquiterpene lactone derived from the plant Artemisia annua L., renowned for its antimalarial activity. Based on this compound, various derivatives and analogues have been obtained that exhibit diverse biological activities, including clinically approved drugs. Recently, increasing evidence has highlighted neuroprotective potential of artemisinin. In study, we evaluated effects artemisinin viability neuronal-like cells, primary hippocampal neuronal cultures. exhibited...
Two series of regioisomeric heterylmethylidene derivatives imidazo[4,5-<italic>e</italic>]thiazolo[3,2-<italic>b</italic>]-1,2,4-triazines and imidazo[4,5-<italic>e</italic>]thiazolo[2,3-<italic>c</italic>]-1,2,4-triazines were synthesized. Several compounds exhibiting high antiproliferative activity found.
A direct approach to the synthesis of previously unknown 1H-1,2,3-triazolylfuroxans, involving nucleophilic substitution nitro group in nitrofuroxans followed by catalytic [3+2] cycloaddition intermediate azidofuroxans 1,3-ketoesters, is reported.The scope triazolylfuroxans was additionally diversified through a number transformations functional groups attached 1,2,3-triazole ring.The cytotoxic activity newly synthesized and reported hetarylfuroxans studied.The NO-donor capability selected...
Anthracycline antitumor antibiotics are one of the promising classes chemotherapeutic agents for cancer treatment. The main deterrent to their use is high toxicity a healthy environment, including cumulative cardiotoxicity. In our work, bipharmacophore molecules containing in structure fragment known anthracycline daunorubicin and doxorubicin natural sesquiterpene lactones were obtained first time. When studying biological activity synthesized compounds, it was found that with equal and,...
A series of tribenzo[g,l,q]-6H-1,4-diazepino[2,3-b]porphyrazines has been synthesized. temperature-dependent steric effect was applied in the mixed Linstead macrocyclization phthalonitrile and 5,7-bis(2'-arylethenyl)-6-propyl-6H-1,4-diazepine-2,3-dicarbonitrile to achieve high yield low-symmetry
We present the results of a histological study into cardiotoxicity conjugates daunorubicin with dehydrocostus lactone and epoxyisoalantolactone in mature male mice C57BL/6 line. The effect on morphology cardiomyocytes structure left ventricular myocardium was studied.
Aims: The main goal of this work is to synthesize new original spirocyclic hydroxamic acids, investigate their cytotoxicity against the panel tumor cell lines and possible mechanism action these active compounds. Background: Hydroxamic acids are one promising classes chemical compounds with proven potential anticancer properties. This manifested in presence metal chelating antioxidant activities, ability inhibit histone deacetylase enzymes a chemosensitizing effect well known cytostatics....
Abstract New conjugates of daunorubicin with sesquiterpene lactones at the 3′‐amino group anthracycline were synthesized and their effect on viability cell lines (HL60, Jurkat, K562, A549) was assessed using a resazurin test. The cycle apoptosis by flow cytometry studied. following natural used for modification: telekin, isotelekin, reynosin, costunolide, dehydrocostuslactone, santamarine epoxyisoalantolactone. are characterized general high toxicity (8…0.14 μM) in relation to tumor (in some...
Background: The conjugates of the sesquiterpene lactone eremophilane series 6- hydroxyxanthanodiene with hydrogenated azines (piperidines and piperazines) have been synthesized identified by NMR spectrometer. Objective: A an unusual skeleton “6-hydroxyxanthanodiene” was extracted from plant Elecampane (Inula helenium L) various species Methods: cytotoxic, mitochondrial, antioxidant activities on different tumor lines such as A549, HCT116, RD Jurkat were investigated determined possible...
A series of tribenzo[g,l,q]-6H-1,4-diazepino[2,3-b]porphyrazines has been synthesized. temperature-dependent steric effect was applied in the mixed Linstead macrocyclization phthalonitrile and 5,7-bis(2’-arylethenyl)-6-propyl-6H-1,4-diazepine-2,3-dicarbonitrile to achieve high selectivity yield low symmetry A3B-type Mg(II) tribenzo[g,l,q]-6H-1,4-diazepino[2,3-b]porphyrazinate. The analysis photophysical photochemical properties obtained complexes showed anti-Kasha effect: ISC quantum turned...