A5015709557- Fullerene Chemistry and Applications
- Free Radicals and Antioxidants
- Electron Spin Resonance Studies
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and biological activity
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Polymer Nanocomposite Synthesis and Irradiation
- Carbon Nanotubes in Composites
- Histone Deacetylase Inhibitors Research
- Synthesis and Characterization of Heterocyclic Compounds
- Porphyrin and Phthalocyanine Chemistry
- Chemical Reactions and Isotopes
- Polymer crystallization and properties
- Nitric Oxide and Endothelin Effects
- Click Chemistry and Applications
- Photodynamic Therapy Research Studies
- Phosphodiesterase function and regulation
- Pharmacological Effects and Toxicity Studies
- Radiation Effects and Dosimetry
- Enzyme function and inhibition
- Plant Genetic and Mutation Studies
- Circadian rhythm and melatonin
- Adenosine and Purinergic Signaling
- Eicosanoids and Hypertension Pharmacology
Institute of Problems of Chemical Physics
2014-2024
Lomonosov Moscow State University
2010-2024
Moscow Region State University
2019-2024
Moscow State University
2023-2024
Scientific Center of RAS in Chernogolovka
2020-2023
Russian Academy of Sciences
2008-2014
Moscow State University of Fine Chemical Technologies
2010
Suppression of the function pineal gland by constant lighting leads to depletion melatonin-producing this gland, and an increase in incidence age-related pathologies, including neoplasms. Melatonin has important antitumor effect, among which antiproliferative effect stands out. Fge composition melanoma patients shifted towards proportion older age groups. There is evidence that melatonin deficiency one factors causing development Study on morphological features transplantable B16 mice. The...
A library of novel 2-(het)arylpyrrolidine-1-carboxamides were obtained via a modular approach based on the intramolecular cyclization/Mannich-type reaction N-(4,4-diethoxybutyl)ureas. Their anti-cancer activities both in vitro and vivo tested. The activity some compounds towards M-Hela tumor cell lines was twice that reference drug tamoxifen, whereas cytotoxicity normal Chang liver did not exceed tamoxifen toxicity. In studies showed number surviving animals day 60 observation up to 83%...
A series of tribenzo[g,l,q]-6H-1,4-diazepino[2,3-b]porphyrazines has been synthesized. temperature-dependent steric effect was applied in the mixed Linstead macrocyclization phthalonitrile and 5,7-bis(2'-arylethenyl)-6-propyl-6H-1,4-diazepine-2,3-dicarbonitrile to achieve high yield low-symmetry
Background: Anti-tumor effect of hydroxamic acid derivatives is largely connected with its properties as efficient inhibitors histone deacetylases, and other metalloenzymes involved in carcinogenesis. Objective: The work was aimed to (i) determine the anti-tumor chemosensitizing activity novel racemic spirocyclic acids using experimental drug sensitive leukemia P388 mice, (ii) structure-activity relationships metal chelating HDAC inhibitory agents. Method: Outbreed male rat 200-220 g weights...
In the case of various pathologies, an imbalance between ROS generation and endogenous AOS can be observed, which leads to excessive accumulation, intensification LPO processes, oxidative stress. For prevention diseases associated with stress, drugs antioxidant activity used. The cytotoxic, antioxidant, NO-donor properties new hybrid compound B6NO (di(3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridinium) salt 2-(nitrooxy)butanedioic acid) were studied. It was determined that chelates iron...
A series of novel water-soluble salts benzofuroxans was achieved via aromatic nucleophilic substitution reaction 4,6-dichloro-5-nitrobenzofuroxan with various amines. The obtained showed good effectiveness the pre-sowing treatment seeds agricultural crops at concentrations 20–40 mmol. In some cases, seed leads not only to improved germination, but also suppression microflora growth. Additionally, their anti-cancer activityin vitrohas been researched. compounds morpholine fragments or a...
Water-soluble fullerene derivatives with thiophene-based addends demonstrated pronounced activity against several types of viruses and record herpes simplex virus.