A5063865672- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chemical Synthesis and Analysis
- Microbial bioremediation and biosurfactants
- Ferrocene Chemistry and Applications
- Synthesis and Catalytic Reactions
- Synthesis and Biological Evaluation
- Bacterial biofilms and quorum sensing
- Engineering Technology and Methodologies
- Microplastics and Plastic Pollution
- Asymmetric Synthesis and Catalysis
- Sulfur-Based Synthesis Techniques
- Carbohydrate Chemistry and Synthesis
- Catalytic C–H Functionalization Methods
- Crystallography and molecular interactions
- Pharmaceutical and Antibiotic Environmental Impacts
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and biological activity
Southern Federal University
2018-2022
Kazan Scientific Center
2019
A library of novel 2-(het)arylpyrrolidine-1-carboxamides were obtained via a modular approach based on the intramolecular cyclization/Mannich-type reaction N-(4,4-diethoxybutyl)ureas. Their anti-cancer activities both in vitro and vivo tested. The activity some compounds towards M-Hela tumor cell lines was twice that reference drug tamoxifen, whereas cytotoxicity normal Chang liver did not exceed tamoxifen toxicity. In studies showed number surviving animals day 60 observation up to 83%...
A first successful synthesis of 2‐(pyrazolyl)pyrrolidines is reported starting from readily available reagents. wide variety N ‐substituted are obtained with up to 96 % yield. The influence the compounds on biofilm formation by V. aquamarinus DSM 26054 and A. calcoaceticus VKPM B–10353 have been studied. Some tested were found suppress growth bacterial biofilms at nanomolar concentrations thus promising candidates for further studies.
Abstract The approach to the novel 1‐[(2‐aminoethyl)sulfonyl]‐2‐arylpyrrolidines via unique intramolecular cyclization/aza‐Michael reactions of N ‐(4,4‐diethoxybutyl)ethenesulfonamide have been developed, which benefits from high yields target compounds, mild reaction conditions, usage inexpensive and low‐toxic reagents, allows for wide variability in both amine aryl moieties. Biotesting with whole‐cell luminescent bacterial biosensors responding DNA damage showed that all tested compounds...
A series of novel 4-aminobenzofuroxan derivatives containing aromatic/aliphatic amines fragments was achieved via aromatic nucleophilic substitution reaction 4,6-dichloro-5-nitrobenzofuroxan. The quantum chemistry calculations were performed to identify the factors affecting regioselectivity reaction. formation 4-substituted isomer is favored both by its greater stability and lower activation barrier. Antimicrobial activity obtained compounds has been evaluated some them found suppress...