A5024996934- Probiotics and Fermented Foods
- Bacterial Genetics and Biotechnology
- Bacterial biofilms and quorum sensing
- Enzyme Structure and Function
- Antimicrobial Peptides and Activities
- Chemical Synthesis and Analysis
- Biotin and Related Studies
- Protein Structure and Dynamics
- Biopolymer Synthesis and Applications
- Hemoglobin structure and function
- Amino Acid Enzymes and Metabolism
- Antifungal resistance and susceptibility
- Synthesis of Organic Compounds
- Antibiotic Resistance in Bacteria
- Microbial Metabolites in Food Biotechnology
- Genomics and Phylogenetic Studies
- Synthesis of heterocyclic compounds
The University of Queensland
2012-2023
Agriculture and Food
2012-2023
University of Da Nang
2015-2023
During construction of several gene deletion mutants in Lactococcus lactis MG1363 which involved a high-temperature (37.5°C) incubation step, additional spontaneous mutations were observed resulted stable heat resistance and some cases salt-hypersensitive phenotypes. Whole-genome sequencing one strain was both resistant salt hypersensitive, followed by PCR four other shared these phenotypes, revealed independent llmg_1816 all cases. This encodes membrane-bound stress signaling protein the...
Summary The second messenger cyclic‐di‐adenosine monophosphate ( c‐di‐AMP ) plays important roles in growth, virulence, cell wall homeostasis, potassium transport and affects resistance to antibiotics, heat osmotic stress. Most F irmicutes contain only one c‐di‐ AMP synthesizing diadenylate cyclase CdaA ); however, little is known about signals effectors controlling activity levels. In this study, a genetic screen was employed identify components which affect the level L actococcus . We...
The broadly conserved bacterial signalling molecule cyclic-di-adenosine monophosphate (c-di-AMP) controls osmoresistance via its regulation of potassium (K+) and compatible solute uptake. High levels c-di-AMP resulting from inactivation phosphodiesterase activity leads to poor growth bacteria under high osmotic conditions. To better understand how can adjust in response excessive identify signals that feed into the network, we characterised genes identified a screen for osmoresistant...
Significance Cyclic di-3′,5′-adenosine monophosphate (c-di-AMP) is a broadly conserved bacterial second messenger that has been implicated in wide range of cellular processes. We report here structural, biochemical, and functional studies on the inhibition Lactococcus lactis pyruvate carboxylase (LlPC) by c-di-AMP. The compound distinct binding mode LlPC compared with Listeria monocytogenes PC. Mutations residues site can abolish c-di-AMP inhibition. required for efficient milk acidification...