A5008480683- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Parkinson's Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological and metabolic disorders
- Stress Responses and Cortisol
- Neurobiology of Language and Bilingualism
- Genetics and Neurodevelopmental Disorders
- Alzheimer's disease research and treatments
- Memory and Neural Mechanisms
- Neuropeptides and Animal Physiology
- Functional Brain Connectivity Studies
- Down syndrome and intellectual disability research
- Autism Spectrum Disorder Research
- Fusion and Plasma Physics Studies
- Long-Term Effects of COVID-19
- Circadian rhythm and melatonin
- MRI in cancer diagnosis
- Neurotransmitter Receptor Influence on Behavior
- Identity, Memory, and Therapy
- Face Recognition and Perception
- Multiple Sclerosis Research Studies
- Breast Lesions and Carcinomas
Centre National de la Recherche Scientifique
2016-2025
Université de Strasbourg
2019-2025
Laboratoire de Biochimie
2025
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2020-2023
Laboratoire Bordelais de Recherche en Informatique
2016
Université de Bordeaux
2016
Institut Polytechnique de Bordeaux
2016
Abstract While depression and chronic pain are frequently comorbid, underlying neuronal circuits their psychopathological relevance remain poorly defined. Here we show in mice that hyperactivity of the pathway linking basolateral amygdala to anterior cingulate cortex is essential for pain-induced depression. Moreover, activation this naive male mice, absence on-going pain, sufficient trigger depressive-like behaviors, as well transcriptomic alterations recapitulate core molecular features...
ABSTRACT Down syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21). The understanding genotype–phenotype relationships, the identification driver genes and various proofs concept for therapeutics have benefited from mouse models. premier model, named Ts(1716)65Dn/J (Ts65Dn), displayed phenotypes related to DS features. It carries an additional minichromosome with Mir155 Zbtb21 region 16, homologous Hsa21, encompassing around 90 genes, fused centromeric part 17 Pisd-ps2/Scaf8...
Background and Objectives: Cerebral complications related to the COVID-19 were documented by brain MRIs during acute phase. The purpose of present study was describe evolution these neuroimaging findings (MRI FDG-PET/CT) neurocognitive outcomes patients. Methods: During first wave outbreak between 1 March 31 May 2020, 112 consecutive patients with neurologic manifestations underwent a MRI at Strasbourg University hospitals. After recovery, follow-up, patients, (initially hospitalized in...
Abstract Background Dementia with Lewy bodies (DLB) is characterized by insular atrophy, which occurs at the early stage of disease. Damage to insula has been associated disorders reflecting impairments most fundamental components self, such as anosognosia, a frequently reported symptom in patients (LB). The purpose this study was investigate modifications self-concept (SC), another component and identify neuroanatomical correlates, prodromal mild DLB. Methods Twenty DLB were selected...
Although deficits in learning and retrieving new information are well characterized dementia with Lewy bodies, autobiographical memory has never been explored this disease. Yet, impairments a pervasive feature of dementia, other neurodegenerative diseases. Moreover, corresponds to an extension over time the self, which we hypothesize is altered bodies impairment could be linked insular atrophy occurring from early stage In study, sought characterize explore their neural correlates on...
Abstract Objectives We have previously demonstrated difficulties in written production dementia with Lewy bodies (DLB) patients. now aim to determine the neural correlates of writing DLB, combining clinical data and structural MRI measures. Method Sixteen prodromal mild DLB patients were selected participate study. The GREMOTS test was used assess production. Using three‐dimensional T1 brain images, correlations between grey matter (GM) volume performed using voxel‐based morphometry (VBM;...
Abstract Objectives To determine the prevalence, localization and associations of cerebral microbleeds (CMB) in dementia with Lewy bodies (DLB) its core clinical symptoms cerebrospinal fluid (CSF) biomarkers Alzheimer's disease (AD). We hypothesize DLB patients CMB have increased amyloid burden compared to those without CMB, which could also translate into differences. Methods Retrospective cross‐sectional analysis from AlphaLewyMA study ( https://clinicaltrials.gov/ct2/show/NCT01876459 )....
Abstract Background and objectives Photophobia is a sensory disturbance provoked by light. Little known about the association between photophobia dementia with Lewy bodies (DLB). In this study, we aimed to identify frequency neural basis of in prodromal mild DLB. Methods One hundred thirteen DLB patients, 53 Alzheimer's disease (AD) 20 AD 31 patients other neurocognitive diseases (including demented patients), healthy elderly controls were included case–control study. was systematically...
MRI is a unique tool to study the complexity of functional and structural communication in brain. To explore brain architecture mouse model Alzheimer's Disease highlight sex-dimorphism emergence AD-like signs, we used recent model, APPNL-F/MAPT double knock-in (dKI). In preclinical imaging, resting-state graph theory approaches longitudinal associated with behavioral evaluation. Functional connectivity perirhinal, dorsal-hippocampus midbrain nodes were implicated early memory impairments dKI...
Dementia with Lewy bodies (DLB) patients show few significant macroscopic structural changes, especially at the early stages of disease, making quantitative MRI interesting to explore more subtle changes that are not detectable by conventional volumetric techniques. Microstructural alterations have been reported in DLB dementia stage, but no study date was conducted prodromal patients. Here, data were collected from 46 and 20 healthy elderly subjects, who also underwent a detailed clinical...
ABSTRACT Down syndrome is caused by trisomy of human chromosome 21 (Hsa21). The understanding phenotype-genotype relationships, the identification driver genes and various proof-of-concepts for therapeutics have benefited from mouse models. premier model, named Ts(17 16 )65Dn/J (Ts65Dn), displayed phenotypes related to DS features. It carries an additional minichromosome with Mir155 t o Zbtb21 region (Mmu16), homologous Hsa21, encompassing around 90 genes, fused centromeric part 17 (Mmu17)...
Abstract Background Attentional deficit is a prominent and distinguishing neuropsychological feature of Dementia with Lewy Bodies (DLB) since the prodromal stages. Our group recently highlighted, using voxel based morphometry (VBM), importance basal ganglia grey matter (GM) integrity for attention processing speed, however, one can hypothesize that white (WM) would also be affected. Accordingly, this study aimed at investigating, in early DLB patients, relationship between impaired speed...
Preoperative diagnosis of phyllodes tumor (PT) is challenging, core-needle biopsy (CNB) has a significant rate understaging, resulting in suboptimal surgical planification. We hypothesized that the association imaging data to CNB would improve preoperative diagnostic accuracy compared alone.In this retrospective pilot study, we included 59 with available imaging, and specimen pathology.Two ultrasound features: heterogeneity shape were associated grade, independently results. Using machine...
Abstract While depression and chronic pain are frequently comorbid, underlying neuronal circuits, their relevance for the understanding of psychopathology, remain poorly defined. Here we show in mice that hyperactivity pathway linking basolateral amygdala to anterior cingulate cortex is essential pain-induced depression. In naive animals, demonstrate activation this sufficient trigger depressive-like behaviors, as well transcriptomic alterations recapitulate core molecular features human...
Narrative discourse (ND) comprehension is a complex task that implies not only linguistic abilities but also other cognitive abilities, including efficient executive functioning. An dysfunction has been described in dementia with Lewy bodies (DLB) from the early stage. Here, we question link between DLB and narrative comprehension. The aim of our study was to evaluate ND investigate neuroanatomical basis for its impairment stage DLB. patients ( N = 26) controls 19) underwent test Montreal...
Erwin is an open-source Python toolbox dedicated to the computation of quantitative maps from MRI data. It provides a unified interface, through either its API or command-line tool, well-known qMRI methods (e.g. B 1 mapping using Actual Flip Angle (AFI) T Variable (VFA)) and external toolboxes MRtrix MEDI). also tools create complex pipelines where dependencies between steps are tracked: change in source image method parameter will only trigger recomputation minimal set subsequent steps.
Cerebral Microbleeds (CMB) have similar frequencies in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) patients, the increased concomitant amyloid burden being one of main explanatory mechanisms. However, there is scarce data regarding prevalence characteristics these lesions early clinical stages, as prodromal mild demented DLB (pDLB) patients. We hypothesize pDLB patients CMB compared to those without, which could also translate differences between groups. Prospective...