A5031005173- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Bioinformatics and Genomic Networks
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Advanced Neuroimaging Techniques and Applications
- Memory and Neural Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Neuropeptides and Animal Physiology
- Neurological and metabolic disorders
- Pain Mechanisms and Treatments
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Spaceflight effects on biology
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Alcohol Consumption and Health Effects
- Mental Health Research Topics
- Graph Theory and Algorithms
- Pain Management and Placebo Effect
- Olfactory and Sensory Function Studies
- Neurological Disease Mechanisms and Treatments
- Prion Diseases and Protein Misfolding
- Optical Imaging and Spectroscopy Techniques
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2017-2023
Université de Strasbourg
2020-2022
Dimensional Imaging (United Kingdom)
2022
Ecole Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)
2021
Centre National de la Recherche Scientifique
2021
Abstract While depression and chronic pain are frequently comorbid, underlying neuronal circuits their psychopathological relevance remain poorly defined. Here we show in mice that hyperactivity of the pathway linking basolateral amygdala to anterior cingulate cortex is essential for pain-induced depression. Moreover, activation this naive male mice, absence on-going pain, sufficient trigger depressive-like behaviors, as well transcriptomic alterations recapitulate core molecular features...
Alzheimer disease (AD) is characterized by the accumulation of amyloid-Beta; plaques and tau neurofibrillary tangles, leading to progressive cognitive decline. Subtle neural adaptations mark preclinical stage AD, occurring years before mild impairment AD diagnosis. Throughout continuum women (~60% cases) demonstrate faster rates decline, greater hippocampal atrophy, more extensive pathology compared men. This particularly evident in early phases. Therefore, investigating sex-specific changes...
In Alzheimer's disease, the tauopathy is known as a major mechanism responsible for development of cognitive deficits. Early biomarkers such affectations diagnosis/stratification are crucial in disease research, and brain connectome studies increasingly show their potential establishing pathology fingerprints at network level. this context, we conducted an vivo multimodal MRI study on young Thy-Tau22 transgenic mice expressing tauopathy, performing resting state functional structural imaging...
MRI is a unique tool to study the complexity of functional and structural communication in brain. To explore brain architecture mouse model Alzheimer's Disease highlight sex-dimorphism emergence AD-like signs, we used recent model, APPNL-F/MAPT double knock-in (dKI). In preclinical imaging, resting-state graph theory approaches longitudinal associated with behavioral evaluation. Functional connectivity perirhinal, dorsal-hippocampus midbrain nodes were implicated early memory impairments dKI...
Dementia with Lewy bodies (DLB) patients show few significant macroscopic structural changes, especially at the early stages of disease, making quantitative MRI interesting to explore more subtle changes that are not detectable by conventional volumetric techniques. Microstructural alterations have been reported in DLB dementia stage, but no study date was conducted prodromal patients. Here, data were collected from 46 and 20 healthy elderly subjects, who also underwent a detailed clinical...
Functional Magnetic Resonance Imaging (fMRI) is an imaging technique that allows to explore brain function in vivo. Many methods dedicated analyzing these data are based on graph modeling, each node corresponding a region and the edges representing their functional link. The objective of this work investigate interest for extracting frequent pattern graphs compare between two populations. Results presented context characterization mouse model Alzheimer's disease comparison with group control mice.
Abstract While depression and chronic pain are frequently comorbid, underlying neuronal circuits, their relevance for the understanding of psychopathology, remain poorly defined. Here we show in mice that hyperactivity pathway linking basolateral amygdala to anterior cingulate cortex is essential pain-induced depression. In naive animals, demonstrate activation this sufficient trigger depressive-like behaviors, as well transcriptomic alterations recapitulate core molecular features human...
Between-species comparisons become essential to validate findings from animal models. In case of Alzheimer’s disease (AD) especially important is evaluate their predictive potential for the sporadic form and assess relevance early stages pathology. Therefore, we used dynamic resting-state functional connectivity investigate comparatively changes in AD patients prodromal Thy-Tau22 mice, a mouse model tauopathy. We highlighted between-species similarities showing less communication...
DYRK1A protein-kinase overexpression was identified as key player in cognitive impairments observed Down syndrome (DS) patients and animal models. Inhibition of this kinase rescued deficits the Dp1Yey mouse model DS, but associated mechanisms remain unknown. Here we used multimodal brain MRI characterized morphology, microstructure functional connectivity (FC) mice. Voxel-based morphometry revealed brain-wide morphological alterations mice, while DTI analysis white matter changes. Further,...