A5045337655- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Protein Kinase Regulation and GTPase Signaling
- Toxin Mechanisms and Immunotoxins
- Signaling Pathways in Disease
- Cell Adhesion Molecules Research
- Bacterial Infections and Vaccines
- Cancer therapeutics and mechanisms
- Protein Tyrosine Phosphatases
- Protein Structure and Dynamics
- Nerve injury and regeneration
- Dermatological and Skeletal Disorders
- Peptidase Inhibition and Analysis
- NF-κB Signaling Pathways
- Synthesis and biological activity
- Glycosylation and Glycoproteins Research
- Pneumonia and Respiratory Infections
- Ovarian function and disorders
- Immune Response and Inflammation
- Caveolin-1 and cellular processes
- Neuropeptides and Animal Physiology
- ATP Synthase and ATPases Research
- Neuroblastoma Research and Treatments
- Clusterin in disease pathology
- Ion channel regulation and function
Inserm
2007-2024
Université Paris Cité
2021-2024
Centre National de la Recherche Scientifique
2021-2024
Institut Cochin
2017-2024
Institut du Fer à Moulin
2007-2022
Sorbonne Université
2007-2022
Université Sorbonne Paris Nord
2011
Institut National de la Recherche Agronomique
2011
Equipe de Recherche en Epidémiologie Nutritionnelle
2011
Assistance Publique – Hôpitaux de Paris
2011
Abstract Neisseria meningitidis (meningococcus) is an invasive bacterial pathogen that colonizes human vessels, causing thrombotic lesions and meningitis. Establishment of tight interactions with endothelial cells crucial for meningococci to resist haemodynamic forces. Two receptors, CD147 the β2-adrenergic receptor (β 2 AR), are sequentially engaged by adhere promote signalling events leading vascular colonization, but their spatiotemporal coordination unknown. Here we report β AR form...
Abstract Multidomain kinases use many ways to integrate and process diverse stimuli. Here, we investigated the mechanism by which protein tyrosine kinase 2-beta (PYK2) functions as a sensor effector of cellular calcium influx. We show that linker between PYK2 FAT domains (KFL) encompasses an unusual calmodulin (CaM) binding element. KFL is disordered engages CaM through ensemble transient events. Calcium increases association promoting structural changes in expose auxiliary interaction...
Proline-rich tyrosine kinase 2 (PYK2) is a non-receptor expressed in many cell types and enriched neurons. PYK2 cytoplasmic enzyme activated by increases cytosolic free Ca(2+) through an unknown mechanism. We report that depolarization or electrical stimulation of hippocampal slices induced rapid transient nuclear accumulation PYK2. Depolarization cultured neurons PC12 cells also triggered Ca(2+)-dependent PYK2, much more pronounced than blockade export with leptomycin B. Src-family...
Therapies targeting the tyrosine kinase receptor HER2 have significantly improved survival of patients with HER2+ cancer. However, both de novo and acquired resistance remain a challenge, particularly in brain metastatic setting. Here we report that, unlike other HER receptors, possesses binding motif its cytosolic juxtamembrane region that allows interaction members Ezrin/Radixin/Moesin (ERM) family. Under physiologic conditions, this controls localization ERM-enriched domains stabilizes...
Human epidermal growth factor receptor 2 (ErbB2/HER2) is a tyrosine kinase that overexpressed in 25% of primary human breast cancers, as well multiple other cancers. HER2-targeted therapies improved progression-free and overall survival patients with HER2+ However, associated resistance mechanisms toxicity highlight the need for new therapeutic approaches these We recently established that, normal cells, HER2 stabilized catalytically repressed state by direct interaction members...
Le surpoids et l’obésité ont vu leur prévalence augmenter dans la population féminine en âge de procréer sont plus fréquents lors des consultations pour infertilité. Ils constituent un facteur non négligeable baisse fertilité naturelle. La graisse abdominale, par le biais l’insulinorésistance, l’hyperinsulinisme l’hyperandrogénie, favorise sur terrain prédisposé à survenue troubles l’ovulation. dépistage prise charge du syndrome métabolique doivent être systématiques ce cadre. L’obtention...
<div>Abstract<p>Therapies targeting the tyrosine kinase receptor HER2 have significantly improved survival of patients with HER2<sup>+</sup> cancer. However, both <i>de novo</i> and acquired resistance remain a challenge, particularly in brain metastatic setting. Here we report that, unlike other HER receptors, possesses binding motif its cytosolic juxtamembrane region that allows interaction members Ezrin/Radixin/Moesin (ERM) family. Under physiologic...
<p>Supplementary methods and data</p>
<p>Supplementary methods and data</p>
<div>Abstract<p>Therapies targeting the tyrosine kinase receptor HER2 have significantly improved survival of patients with HER2<sup>+</sup> cancer. However, both <i>de novo</i> and acquired resistance remain a challenge, particularly in brain metastatic setting. Here we report that, unlike other HER receptors, possesses binding motif its cytosolic juxtamembrane region that allows interaction members Ezrin/Radixin/Moesin (ERM) family. Under physiologic...