A5092591341- Advanced MRI Techniques and Applications
- Glioma Diagnosis and Treatment
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Lanthanide and Transition Metal Complexes
- Radioactive element chemistry and processing
- Electron Spin Resonance Studies
- Medical Imaging Techniques and Applications
Leiden University Medical Center
2021-2025
Delta Institute for Theoretical Physics
2023
ABSTRACT Gliomas are highly heterogeneous and often include a nonenhancing component that is hyperintense on T 2 weighted MRI. This can not be distinguished from secondary gliosis surrounding edema. We hypothesized the extent of these areas more accurately determined high‐quality 7 MRI scans. investigated extension, volume, complexity (shape) in patients with glioma scans compared to clinical 28 were visually manually segmented corresponding (1.5 T/3 T) scans, volume shape markers calculated...
Purpose Current challenges of in vivo CEST imaging include overlapping signals from different pools. The overlap arises closely resonating pools and/or the broad magnetization transfer contrast (MTC) macromolecules. This study aimed to evaluate feasibility variable delay multipulse (VDMP) separately assess solute with chemical exchange rates human brain , while mitigating MTC. Methods VDMP saturation buildup curves were simulated for amines, amides, and relayed nuclear Overhauser effect....
Abstract Metabolite‐weighted chemical exchange saturation transfer MRI can be used to indirectly image metabolites such as creatine and glutamate. This study aims further explore the contrast of CEST at 2 ppm in human brain 7T investigate metabolite correlates via correlations with magnetic resonance spectroscopy (MRS). Simulations were performed establish optimal acquisition parameters, total time (t sat ) B 1 root mean squared (B rms) for brain. Parameters validated vitro phantom studies...
Arterial spin labeling (ASL) and dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) have shown potential for differentiating tumor progression from pseudoprogression. For pseudocontinuous ASL with a single postlabeling delay, the presence of delayed arterial transit times (ATTs) could affect evaluation ASL-MRI perfusion data. In this study, influence ATT artifacts on assessment differentiation between pseudoprogression were studied. This study comprised 66 adult patients...
Despite multimodal anti-tumor treatment, glioblastomas typically progress, yet identifying true tumor progression on MRI-scans is challenging. We aimed to establish brain MRI phenotypes of by combined analysis radiological scoring structural and perfusion characteristics 3-months post-radiotherapy. Hierarchical clustering method was applied group patients similar it analyzed whether these groups showed differences in overall survival outcome. Four distinct glioblastoma were established...
Amine chemical exchange saturation transfer (CEST) is highly sensitive for imaging metabolites in vivo. However, it lacks specificity. We aimed to develop and validate optimal CEST protocols image creatine glutamate the human brain at 7T. Simulations were used define acquisition parameters, followed by vitro validation. The B1rms total (tsat) parameters determined (B1rms = 2.5μT & tsat 1500ms) 3.5μT 1000ms). These then healthy volunteers investigate correlation of glutamate-...
Early treatment effects in patients with glioblastoma are frequently discussed during multidisciplinary team meetings (MDTM), after which a decision regarding (dis)continuation of tumor-targeted is made. This study examined whether separate and systematic evaluation perfusion MRI (pMRI) could impact such decisions the early stage. retrospective observational evaluated diagnostic accuracy for detecting tumor progression 4 different approaches including conventional MRI, pMRI Arterial Spin...
Distinguishing true tumor progression (TP) from treatment-induced abnormalities (eg, pseudo-progression (PP) after radiotherapy) on conventional MRI scans remains challenging in patients with a glioblastoma. We aimed to establish brain phenotypes of glioblastomas early treatment by combined analysis structural and perfusion characteristics assessed the relation recurrence rate overall survival time.Structural MR images 67 at 3 months post-radiotherapy were visually scored neuroradiologist....