This study investigated whether blood concentrations of leptin, ghrelin, and adiponectin are affected by acute total sleep deprivation in a sex- weight-specific manner.A 44 participants (mean age 24.9 years; 20 women; 19 with obesity) participated crossover design, including one night the laboratory. After each night, fasting was collected.After deprivation, levels leptin were lower [SE], vs. sleep: 17.3 [2.6] 18.6 [2.8] ng/mL), whereas those ghrelin higher (839.4 [77.5] 741.4 [63.2] pg/mL...

Abstract INTRODUCTION We aimed to investigate the association between white matter hyperintensity (WMH) shape and volume long‐term dementia risk in community‐dwelling older adults. METHODS Three thousand seventy‐seven participants (mean age: 75.6 ± 5.2 years) of Age Gene/Environment Susceptibility (AGES)‐Reykjavik study underwent baseline 1.5T brain magnetic resonance imaging were followed up for follow‐up: 9.9 2.6 years). RESULTS More irregular periventricular/confluent WMH (lower solidity...

ABSTRACT Gliomas are highly heterogeneous and often include a nonenhancing component that is hyperintense on T 2 weighted MRI. This can not be distinguished from secondary gliosis surrounding edema. We hypothesized the extent of these areas more accurately determined high‐quality 7 MRI scans. investigated extension, volume, complexity (shape) in patients with glioma scans compared to clinical 28 were visually manually segmented corresponding (1.5 T/3 T) scans, volume shape markers calculated...

WMH shape is associated with long-term risk for dementia after 10 years in community-dwelling older adults. The current study aimed to investigate the association of and decline three cognitive domains over five years' time baseline (solidity, convexity, concavity index, fractal dimension, eccentricity) 5.2 ± 0.3 (domains: memory, executive function, processing speed) was investigated using linear regression models Age, Gene/Environment Susceptibility-Reykjavik (AGES) (n = 2493). A more...

The underlying mechanisms of the association between cardiovascular risk factors and a higher white matter hyperintensity (WMH) burden are unknown. We investigated advanced WMH markers in 155 non-demented older adults (mean age: 71±5 years). quantitative MRI-based shape volume were examined using linear regression analysis. Presence hypertension was associated with more irregular periventricular/confluent (convexity (B (95%-CI)): -0.12 (-0.22–-0.03); concavity index: 0.06 (0.02–0.11)), but...

Individual brain MRI markers only show at best a modest association with long-term occurrence of dementia. Therefore, it is challenging to accurately identify individuals increased risk for We aimed different phenotypes by hierarchical clustering analysis based on combined neurovascular and neurodegenerative determine the dementia within phenotype subgroups.

Background: Acute sleep loss increases the brain’s reactivity toward positive and negative affective stimuli. Thus, despite well-known reduced attention due to acute loss, we hypothesized that humans would gaze longer on happy, angry, fearful faces than neutral when sleep-deprived. We also examined if facial expressions are differently perceived after loss. Methods: In present, within-subjects study, 45 young adults participated in one night of total deprivation with an 8-hour opportunity....

White matter hyperintensity (WMH) shape is associated with long-term dementia risk in community-dwelling older adults, however, the underlying structural correlates of this association are unknown. We therefore aimed to investigate between baseline WMH and cerebrovascular disease progression over time adults. The markers was investigated using linear logistic regression models Age, Gene/Environment Susceptibility-Reykjavik (AGES) study (n = 2297; average follow-up: 5.2 years). A more...

Individual brain MRI markers only show at best a modest association with long-term occurrence of dementia. Therefore, it is challenging to accurately identify individuals increased risk for We implemented combined hierarchical clustering analysis based on neurodegenerative and neurovascular identified 14 distinct subgroups different phenotypes. These had dementia; especially the multi-burden phenotype showed an (HR: 13.8 (95%-CI:4.28-44.37)). findings may in future be useful determine...

Despite multimodal anti-tumor treatment, glioblastomas typically progress, yet identifying true tumor progression on MRI-scans is challenging. We aimed to establish brain MRI phenotypes of by combined analysis radiological scoring structural and perfusion characteristics 3-months post-radiotherapy. Hierarchical clustering method was applied group patients similar it analyzed whether these groups showed differences in overall survival outcome. Four distinct glioblastoma were established...

White matter hyperintensity (WMH) shape was recently introduced as a novel small vessel disease (SVD) marker that may provide more detailed characterization of WMH than volume alone. We aimed to investigate the association between baseline and cerebrovascular progression over 5 years. A irregular periventricular/confluent deep at is associated with increased volume. Moreover, occurrence new microbleeds subcortical infarcts follow-up. Our findings indicate SVD progression.

Motivation: Dirty-appearing white matter (DAWM) might be an early marker of cerebral small vessel disease (SVD) progression. Goal(s): To investigate whether dirty-appearing on brain MRI is related to long-term progression SVD markers in a cohort community-dwelling older adults. Approach: We visually rated DAWM volume fraction baseline FLAIR images (n=2506) and this multiple at the 5.2-year follow-up. Results: Global occipital associated with increase global hyperintensity (WMH) This suggests...

Motivation: Glymphatic clearance is impaired in neurodegenerative disease. Vasomotion has been suggested to drive CSF flow and influence clearance. Furthermore, low frequency sensory stimulation can enhance vasomotion. Whether visual humans still unclear. Goal(s): To study the effect of different frequencies on BOLD signal flow. Approach: 7T BOLD-fMRI scans were acquired healthy volunteers watching a checkerboard flashing at 0.025, 0.05, or 0.1 Hz. Results: Visual cortex responses clearly...

Recently white matter hyperintensity (WMH) shape was introduced as a promising novel marker that may provide more detailed characterization of WMH than volume alone. We aimed to investigate the association between and occurrence dementia later in life community dwelling older adults. markers volumes were determined for periventricular/confluent, deep WMH. A complex periventricular/confluent (higher fractal dimension), well total volume, associated with greater risk dementia. These results...

Abstract BACKGROUND Distinguishing between true tumor progression (TP) and treatment induced abnormalities (e.g. pseudo-progression (PP) after radiotherapy) early on conventional MRI scans remains challenging for glioblastomas (GBM). Despite perfusion techniques being promising in differentiating TP PP, individual imaging markers have only showed a modest association with overall survival. Therefore, we aimed to establish brain phenotypes of by combined analysis radiological scoring...

Distinguishing true tumor progression (TP) from treatment-induced abnormalities (eg, pseudo-progression (PP) after radiotherapy) on conventional MRI scans remains challenging in patients with a glioblastoma. We aimed to establish brain phenotypes of glioblastomas early treatment by combined analysis structural and perfusion characteristics assessed the relation recurrence rate overall survival time.Structural MR images 67 at 3 months post-radiotherapy were visually scored neuroradiologist....

Abstract Background White matter hyperintensity (WMH) shape was recently introduced as a novel small vessel disease (SVD) marker that may provide more detailed characterization of WMH than volume alone. We aimed to investigate the association between baseline and cerebrovascular progression over 5 years in community‐dwelling individuals. Method Data from Age, Gene/Environment Susceptibility‐Reykjavik (AGES) study (n = 2297) used current study. FLAIR T1‐weighted brain MRI scans were acquired...

Abstract Background Individual brain MRI markers only show at best a modest association with long‐term occurrence of dementia. Therefore, it is challenging to accurately identify individuals increased risk for We aimed different phenotypes by combined hierarchical clustering analysis based on neurodegenerative and neurovascular in community‐dwelling individuals. Within each these phenotype subgroups, we determined the dementia risk. Method A Age‐Gene/Environment Susceptibility (AGES)...