Jean-Rodolphe Mackanga

ORCID: 0000-0003-1781-7183
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About
Contact & Profiles
Research Areas
  • Malaria Research and Control
  • Global Maternal and Child Health
  • Healthcare professionals’ stress and burnout
  • HIV/AIDS drug development and treatment
  • Hepatitis B Virus Studies
  • HIV-related health complications and treatments
  • Hepatitis C virus research
  • Parasites and Host Interactions
  • Electrolyte and hormonal disorders
  • Empathy and Medical Education
  • Liver Disease Diagnosis and Treatment
  • Mosquito-borne diseases and control
  • Child Nutrition and Water Access
  • Potassium and Related Disorders
  • Hepatitis Viruses Studies and Epidemiology
  • School Health and Nursing Education
  • Pharmacological Effects and Toxicity Studies
  • Electroconvulsive Therapy Studies
  • Patient Satisfaction in Healthcare
  • Drug-Induced Hepatotoxicity and Protection
  • Medical Education and Admissions
  • Antimicrobial Resistance in Staphylococcus
  • Streptococcal Infections and Treatments
  • Clinical Reasoning and Diagnostic Skills
  • Chronic Obstructive Pulmonary Disease (COPD) Research

Centre de Recherche Médicales de Lambaréné
2012-2021

Université de Bretagne Sud
2021

Université des Sciences de la Santé
2013-2020

Nantes Université
2019-2020

Libreville Hospital
2011-2019

Albert Schweitzer Hospital
2013-2018

University of Tübingen
2012-2018

Centre d'Investigation Clinique de Nantes
2016

Centre Hospitalier Universitaire de Nantes
2016

Clara Menéndez and colleagues conducted an open-label randomized controlled trial in HIV-negative pregnant women Benin, Gabon, Mozambique, Tanzania to evaluate the safety efficacy of mefloquine compared sulfadoxine-pyrimethamine for intermittent preventative therapy malaria. Please see later article Editors' Summary

10.1371/journal.pmed.1001733 article EN cc-by PLoS Medicine 2014-09-23

Background. Urogenital schistosomiasis is a major public health problem in sub-Saharan Africa, and routine programs for screening treatment of pregnant women are not established. Mefloquine—currently evaluated as potential alternative to sulfadoxine-pyrimethamine intermittent preventive against malaria pregnancy (IPTp)—is known exhibit activity Schistosoma haematobium. In this study we the efficacy mefloquine IPTp S. haematobium infection women.

10.1093/cid/cis976 article EN Clinical Infectious Diseases 2012-11-21

Background Malnutrition and low birth weight (LBW) are two common causes of morbidity mortality among children in sub-Saharan Africa. Both malnutrition LBW affect early childhood development with long term consequences that may vary their degree depending on the geographical setting. This study evaluates growth, nutritional status infants from Lambaréné Fougamou Gabon a cohort malaria pregnancy clinical trial (NCT00811421). Method A prospective longitudinal conducted between 2009 2012,...

10.1371/journal.pone.0246694 article EN cc-by PLoS ONE 2021-02-09

Abstract Background Malaria remains one of the most important infectious diseases in pregnancy sub-Saharan Africa. Whereas seasonal malaria chemoprevention is advocated as public health intervention for children certain areas highly transmission, impact seasonality on has not yet been investigated stable, hyper-endemic transmission settings Equatorial The aim this study was to investigate influence prevalence Gabon. Methods conducted at a rural district hospital Gabon between January 2008...

10.1186/1475-2875-12-412 article EN cc-by Malaria Journal 2013-11-13

Abstract Background Burnout in the hospital environment is a problem that affects care and training. Often explored high-income medical context, burnout poorly studied low middle-income countries characterized by precarious situation high stake linked to Millennium Development Goals. The aim of our study was determine practitioners, sub-Saharan African country’s level associated factors. Methods A prospective cross-sectional using self-administered Likert-scale questionnaire addressed...

10.1186/s12909-020-02194-2 article EN cc-by BMC Medical Education 2020-09-10

Children below the age of six months suffer less often from malaria than older children in sub-Saharan Africa. This observation is commonly attributed to persistence foetal haemoglobin (HbF), which considered not permit growth Plasmodium falciparum and therefore providing protection against malaria. Since this concept has recently been challenged, study evaluated effect HbF erythrocytes maternal plasma on vitro parasite P. Central African Gabon. Umbilical cord blood peripheral were collected...

10.1186/1475-2875-13-436 article EN cc-by Malaria Journal 2014-11-18

Premastication—defined as pre-chewing of food for infants by their caregiver—is a common feeding practice in various societies. To date the impact premastication on children’s health including potential transmission infectious diseases is not well understood. Since there are no epidemiologic data from resource poor regions Central Africa, we investigated epidemiology and demographic variables associated with Africa. Between 2011 2012, mothers were interviewed about child behaviors three...

10.1093/tropej/fmt082 article EN Journal of Tropical Pediatrics 2013-10-03

Mefloquine was evaluated as an alternative for intermittent preventive treatment of malaria in pregnancy (IPTp) due to increasing resistance against the first-line drug sulfadoxine-pyrimethamine (SP). This study determined pharmacokinetic characteristics mefloquine stereoisomers and metabolite carboxymefloquine (CMQ) when given IPTp pregnant women. Also, relationship between plasma concentrations three analytes cord samples evaluated, potential covariates influencing properties were...

10.1128/aac.01113-18 article EN Antimicrobial Agents and Chemotherapy 2018-11-20

Abstract Background Burnout, a real barrier to care, whose knowledge has often been established in the high-income medical context. However, low and middle-income countries, such as sub-Saharan Africa, which is characterized by precarious hospital situation high stakes linked Millennium Development Goals, burnout poorly studied. The objective of our study was evaluate, context one African country, level associated factors.Methods prospective cross-sectional concerning doctors doctoral...

10.21203/rs.2.14191/v1 preprint EN cc-by Research Square (Research Square) 2019-09-10

Abstract Background: burnout in the hospital environment is a problem that affects care and training. Often explored high-income medical context, poorly studied low middle-income countries characterized by precarious situation high stake linked to Millennium Development Goals. The aim of our study was determine practitioners, sub-Saharan African country’s level associated factors. Methods: prospective cross-sectional using self-administered Likert-scale questionnaire addressed doctors...

10.21203/rs.2.14191/v2 preprint EN cc-by Research Square (Research Square) 2020-03-23

Abstract Background: burnout in the hospital environment is a problem that affects care and training. Often explored high-income medical context, poorly studied low middle-income countries characterized by precarious situation high stake linked to Millennium Development Goals. The aim of our study was determine practitioners, sub-Saharan African country’s level associated factors. Methods : prospective cross-sectional using self-administered Likert-scale questionnaire addressed doctors...

10.21203/rs.2.14191/v3 preprint EN cc-by Research Square (Research Square) 2020-08-05

La bilharziose hepatique est la consequence de l’embolisation des œufs schistosomes au niveau veinules portes hepatiques. Elle a l’origine d’une fibrose sequellaire, responsable hypertension portale [1]. Sa description toujours associee Schistosoma mansoni et aux asiatiques (Schistosoma japonicum mekongi) Nous nous sommes interroges sur l’existence cette affection Gabon ou les especes endemiques sont intercalatum haematobium. Ce travail avait pour objectif d’etablir d’en preciser...

10.1007/s12157-011-0335-6 article FR Journal Africain d Hépato-Gastroentérologie 2011-11-17
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