A5041912518- Malaria Research and Control
- Global Maternal and Child Health
- Tuberculosis Research and Epidemiology
- HIV/AIDS Research and Interventions
- Pneumonia and Respiratory Infections
- HIV Research and Treatment
- Child Nutrition and Water Access
- Mosquito-borne diseases and control
- Complement system in diseases
- Parasites and Host Interactions
- Respiratory viral infections research
- HIV/AIDS drug development and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Poverty, Education, and Child Welfare
- SARS-CoV-2 and COVID-19 Research
- COVID-19 diagnosis using AI
- COVID-19 Impact on Reproduction
- Pharmacological Effects and Toxicity Studies
- Diagnosis and treatment of tuberculosis
- COVID-19 epidemiological studies
- Mycobacterium research and diagnosis
- Vaccine Coverage and Hesitancy
- Health Systems, Economic Evaluations, Quality of Life
- SARS-CoV-2 detection and testing
- Global Health and Epidemiology
London School of Hygiene & Tropical Medicine
2020-2024
Liverpool School of Tropical Medicine
2023
Barcelona Institute for Global Health
2014-2021
Manhiça Health Research Centre
2014-2021
Universitat de Barcelona
2014-2021
University of London
2020-2021
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2016-2018
Centre de Recerca en Economia Internacional
2015
Clara Menéndez and colleagues conducted an open-label randomized controlled trial in HIV-negative pregnant women Benin, Gabon, Mozambique, Tanzania to evaluate the safety efficacy of mefloquine compared sulfadoxine-pyrimethamine for intermittent preventative therapy malaria. Please see later article Editors' Summary
Objectives One of Africa's most important challenges is to improve maternal and neonatal health. The identification groups at highest risk for adverse pregnancy outcomes developing implementing targeted prevention programmes. This study assessed whether young adolescent girls constitute a group increased birth among pregnant women in sub-Saharan Africa. Setting Data were collected prospectively as part large randomised controlled clinical trial evaluating intermittent preventive treatment...
Tuberculosis (TB) prevalence remains persistently high in many settings, with new or expanded interventions required to achieve substantial reductions. The HIV Prevention Trials Network (HPTN) 071 (PopART) community-randomised trial randomised 14 communities receive the "PopART" intervention during 2014 2017 (7 arm A and 7 B communities) standard-of-care (arm C). was delivered door-to-door by community care providers (CHiPs) included universal testing, facilitated linkage at government...
Clara Menéndez and colleagues conducted a randomized controlled trial among HIV-positive pregnant women in Kenya, Mozambique, Tanzania to investigate the safety efficacy of mefloquine as intermittent preventative therapy for malaria receiving cotrimoxazole prophylaxis long-lasting insecticide treated nets. Please see later article Editors' Summary
ObjectivesThe objective of this study was to inform public health actions limit first-line ART failure and HIV drug resistance in Mozambique.
Prevention of reinfection and resurgence is an integral component the goal to eradicate malaria. However, adverse effects malaria resurgences are not known.We assessed prevalence Plasmodium falciparum infection among 1819 Mozambican women who delivered infants between 2003 2012. We used microscopic histologic examination a quantitative polymerase-chain-reaction (qPCR) assay, as well flow-cytometric analysis IgG antibody responses against two parasite lines.Positive qPCR tests for P....
WHO recommends community-wide, systematic tuberculosis screening in high-prevalence settings. C-reactive protein has been proposed as a tool for people living with HIV. We aimed to assess the performance of point-of-care test community two countries high burden.
Introduction The HIV epidemic is concentrated in sub-Saharan Africa. However, limited information exists on its impact women and infant's health since the introduction of antiretroviral drugs this region, where resources are often scarce. Methods effect infection maternal health, birth outcomes infant was analysed two contemporary cohorts HIV-uninfected HIV-infected pregnant from southern Mozambique. Pregnant attending first antenatal care visit were followed until one month after delivery....
Background Intermittent Preventive Treatment (IPTp) and insecticide treated nets (ITNs) are recommended malaria in pregnancy preventive interventions sub-Saharan Africa. Despite their cost-effectiveness seemingly straight-forward delivery mechanism, uptake remains low. We aimed at describing perceptions of pregnant women regarding the prevention to understand barriers help improve effectiveness. Methods findings used mixed methods collect data among 85 from a rural area Southern Mozambique....
Preterm and small for gestational age (SGA) births have been associated with adverse outcomes during the first stages of life. We evaluated morbidity mortality preterm SGA year life in a rural area Southern Mozambique.This is retrospective cohort study using previously collected data from children born at Manhiça District Hospital two different periods (2003-2005 2010-2012). Newborns were classified as being and/or or babies not fulfilling any previous conditions (term non-SGA). All followed...
To assess morbidity and mortality in HIV-exposed uninfected (HEU) children to help guiding appropriate clinical care effective preventive interventions.This is a longitudinal study comparing two cohorts of children; one born HIV-infected women the other HIV-uninfected women.We have analyzed prospectively obtained information on nutritional status, from 966 HEU 909 HIV-unexposed infants followed up until their first 18 months life at referral health facility southern Mozambique. Determinants...
Transplacental transfer of antibodies is essential for conferring protection in newborns against infectious diseases. We assessed the impact different factors, including gestational age and maternal infections such as HIV malaria, on efficiency cord blood levels placental IgG subclasses. measured total subclasses by quantitative suspension array technology 14 pathogens vaccine antigens, targets immunization, 341 delivering HIV-uninfected HIV-infected mother-infant pairs from southern...
•SARS-CoV-2 seroprevalence survey conducted between October 2020 and March 2021.•Overall of approximately 13.5% in one community Zambia.•Sharp increase prevalence was seen (up to 35%) mid-February 2021.•Strong time trend levels seropositivity parallel with the epidemic.•Useful urgent seroepidemiological data needed for public health responses. BackgroundWe nested a within TREATS (Tuberculosis Reduction through Expanded Antiretroviral Treatment Screening) project. We aimed measure SARS-CoV-2...
Objectives Prevalence surveys remain the best way to assess national tuberculosis (TB) burden in many countries. Challenges with using culture (the reference standard) for TB diagnosis prevalence have led increasing use of molecular tests (Xpert assays), but discordance between these two has created problems deciding which individuals TB. We aimed design an accurate diagnostic algorithm (TBPS) that limits culture. Design TBPS four communities, conducted during 2019. Setting Three Zambian...
Little is known about the effects of intermittent preventive treatment malaria in pregnancy (IPTp) on health sub-Saharan African infants. We have evaluated safety IPTp with mefloquine (MQ) compared to sulfadoxine-pyrimethamine (SP) for important infant and developmental outcomes.In context a multicenter randomized controlled trial evaluating efficacy MQ SP carried out four countries (Mozambique, Benin, Gabon, Tanzania), 4,247 newborns, 2,815 born women who received 1,432 IPTp, were followed...
Achieving effective antiretroviral treatment (ART) monitoring is a key determinant to ensure viral suppression and reach the UNAIDS 90-90-90 targets. The gold standard for detecting virological failure plasma human immunodeficiency virus (HIV) RNA (viral load [VL]) testing; however, its availability very limited in low-income countries due cost operational constraints. HIV-1–infected adults on first-line ART attending routine visits at Manhiça District Hospital, Mozambique, were previously...
A major unresolved safety concern for malaria case management is the use of artemisinin combination therapies (ACTs) in first trimester pregnancy. There a need human data to inform policy makers and treatment guidelines on (ACT) when used during early The overall goal this paper describe methods implementation study aimed at developing surveillance systems identifying exposures antimalarials pregnancy monitoring outcomes using health demographic platforms. This was multi-center prospective...
BackgroundIntegrated Management of Childhood Illness (IMCI) guidelines were developed to decrease morbidity and mortality, yet implementation varies across settings. Factors associated with poor adherence are not well understood.MethodsWe used data from Manhiça District Hospital outpatient department five peripheral health centers examine pneumonia management for children <5 years old January 2008 June 2011. Episodes IMCI-defined (cough or difficult breathing plus tachypnea), severe...
HPTN071 (PopART) was a cluster randomized trial conducted in Zambian and South African (SA) communities, between 2013-2018. The PopART intervention (universal HIV-testing treatment (UTT) combined with population-level TB symptom screening) implemented 14 communities. TREATS study (2017-2021) to evaluate the impact of on outcomes. We report TB/HIV incidence infection cohort adolescents young adults (AYA) aged 15-24 years.A random sample AYA enrolled July 2018 2019 7 vs standard-of-care...
Background Pregnant women exposed to Plasmodium falciparum generate antibodies against VAR2CSA, the parasite protein that mediates adhesion of infected erythrocytes placenta. There is a need high-throughput tools determine fine specificity these can be used identify immune correlates protection and exposure. Here we aimed at developing multiplex-immunoassay detect VAR2CSA antigens. Methods findings We constructed two multiplex-bead arrays, one composed 3 recombinant-domains (DBL3X, DBL5Ɛ...
Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. We used multiplex peptide-based suspension array in 2,354 samples from pregnant Mozambique, Benin, Kenya, Gabon, Tanzania, and Spain. Two VAR2CSA peptides limited polymorphism were immunogenic...