A5041860058- Genetic diversity and population structure
- Genetic and phenotypic traits in livestock
- Wildlife Ecology and Conservation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Plant and animal studies
- Animal Genetics and Reproduction
- Genetic Mapping and Diversity in Plants and Animals
- Species Distribution and Climate Change
- Sexual Differentiation and Disorders
- Metabolism and Genetic Disorders
- Child and Animal Learning Development
- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
- Neuroendocrine regulation and behavior
- Identification and Quantification in Food
- Animal Behavior and Welfare Studies
- Genetic and Environmental Crop Studies
- Aquaculture disease management and microbiota
- Reproductive Biology and Fertility
- Avian ecology and behavior
- Urological Disorders and Treatments
- Ecology and Vegetation Dynamics Studies
- Chromosomal and Genetic Variations
- Bat Biology and Ecology Studies
- Hormonal and reproductive studies
Perot Museum of Nature and Science
2025
San Diego Zoo Institute for Conservation Research
2016-2023
Zoological Society of San Diego
2011-2023
The University of Sydney
2016
University of California, San Diego
2007-2008
New York Hospital Queens
2001-2003
NewYork–Presbyterian Hospital
2001-2003
Cornell University
2001-2003
Congenital adrenal hyperplasia (CAH) refers to a family of monogenic inherited disorders steroidogenesis most often caused by enzyme 21-hydroxylase deficiency (21-OHD). In the classic forms CAH (simple virilizing and salt wasting), androgen excess causes external genital ambiguity in newborn females progressive postnatal virilization males females. Prenatal treatment with dexamethasone has been successfully used for over decade. This article serves as an update on 532 pregnancies prenatally...
The conservation of species is one the foundations biology.Successful has often been defined as simply avoidance extinction.We argue that this focus, although important, amounts to practicing at "emergency room door," and will never be a sufficient approach conserving species.Instead, we elaborate positive definition on basis six attributes propose categorization different states using extent human management degree which each conserved.These can used develop taxonomy "recovery" acknowledges...
Cloning from historically cryopreserved cells offers a potential means to restore lost genetic variation or increase the representation of particular lineages within bottlenecked species, provided such biobanked materials are archived for rescue applications. One species which cloning can provide management benefits is Przewalski's horse, Equus przewalskii. All ~1800 living horses, distributed across ex situ breeding facilities and in reintroduction sites, descended one more five founder...
We investigate multilocus patterns of differentiation between parental populations two swallowtail butterfly species that differ at a number ecologically important sex-linked traits. Using new coalescent-based approach, we show there is significant heterogeneity in estimated divergence times among five Z-linked markers, rejecting purely allopatric speciation model. infer the Z chromosome mosaic regions extent historical gene flow, potentially due to isolating barriers prevent introgression...
The arginine vasopressin V1a receptor (V1aR) modulates social cognition and behavior in a wide variety of species. Variation repetitive microsatellite element the 5' flanking region V1aR gene (AVPR1A) rodents has been associated with variation brain expression behavior. In humans, AVPR1A contains tandem duplication two approximately 350 bp, microsatellite-containing elements located 3.5 kb upstream transcription start site. first block, referred to as DupA, polymorphic (GT)25 microsatellite;...
Captive breeding programs for wildlife species typically rely on pedigrees to inform genetic management. Although pedigree-based strategies are quite effective at retaining long-term variation, management of zoo-based continues be hampered when poorly known. The objective this study was evaluate 2 options generating single nucleotide polymorphism (SNP) data resolve unknown relationships within captive programs. We generated SNP a population addax (Addax nasomasculatus) using both the...
Researchers have long debated which estimator of relatedness best captures the degree relationship between two individuals. In genomics era, this debate continues, with estimates being sensitive to methods used generate markers, marker quality, and levels diversity in sampled Here, we compare six commonly genome-based estimators (kinship genetic distance [KGD], Wang maximum likelihood [TrioML], Queller Goodnight [Rxy ], Kinship INference for Genome-wide association studies [KING-robust),...
Zoo-based captive breeding programs typically rely on accurate pedigrees to maintain long-term population genetic diversity and prevent close inbreeding. For many mixed-sex populations, it is difficult assign parentage of offspring with certainty without conducting DNA-based analyses. Using the demographic parameters a North American Arabian oryx (Oryx leucoryx), 2 kinship-based breeding-pair selection strategies were modeled for their performance in handling varying degrees uncertainty. We...
Conference Proceedings: Genetic and Hormonal Basis of Sexual Differentiation Disorders: CLINICAL NOTE
Abstract Locally isolated populations in marginal habitats may be genetically distinctive and of heightened conservation concern. Elephants inhabiting the Namib Desert have been reported to show behavioral phenotypic adaptations that severely arid environment. The genetic distinctiveness Namibian desert elephants relative other African savanna elephant ( Loxodonta africana ) has not established. To investigate structure Namibia, we determined mitochondrial (mt) DNA control region sequences...
Abstract Two endangered Przewalski’s horse stallions were cloned from fibroblast cells cultured and cryopreserved in 1980. These are clones of a male that lived 1975-1998 pedigree analyses identified as genetically valuable for present-day conservation breeding. This is the first time multiple healthy have been produced an species.
Abstract Researchers have long debated which estimator of relatedness best captures the degree relationship between two individuals. In genomics era, this debate continues, with estimates being sensitive to methods used generate markers, marker quality, and levels diversity in sampled Here, we compare six commonly genome-based estimators (kinship genetic distance (KGD), Wang Maximum Likelihood (TrioML), Queller Goodnight (R xy ), Kinship INference for Genome-wide association studies...
Abstract Hybridization among closely related species is a concern in zoo and aquarium populations where unpedigreed animals are frequently exchanged with the private sector. In this study, we examine possible hybridization group of Nubian ibex ( Capra nubiana ) imported into Association Zoos Aquariums’ (AZA) Species Survival Program (SSP) from institution. These individuals appeared smaller stature than adult SSP were excluded breeding recommendations over that they hybrids. Twenty‐six...
Abstract The application of molecular tools to population management can improve the long-term genetic viability ex situ populations. In this study, we aimed understand implications integrating empirical kinships into an endangered waterfowl, Baer’s pochard (Aythya baeri), in North America. Single nucleotide polymorphism data were generated for 141 using double digest restriction site-associated DNA sequencing and derived integrated software PMx. Analyses suggested 37.7% pairwise...