A5042618428- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Systemic Lupus Erythematosus Research
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Psoriasis: Treatment and Pathogenesis
- Immune cells in cancer
- Autoimmune Bullous Skin Diseases
University of Washington
2021-2024
Benaroya Research Institute
2018-2022
Center for Translational Molecular Medicine
2022
Virginia Mason Medical Center
2022
The mucosal origins hypothesis of rheumatoid arthritis (RA) proposes a central role for immune responses in the initiation or perpetuation systemic autoimmunity that occurs with disease. However, connection between mucosa and RA remains unclear. Using dual immunoglobulin A (IgA) IgG family plasmablast–derived monoclonal autoantibodies obtained from peripheral blood individuals at risk RA, we identified cross-reactivity RA-relevant autoantigens bacterial taxa closely related families...
The coinhibitory receptor lymphocyte activation gene 3 (LAG-3) is an immune checkpoint molecule that negatively regulates T cell activation, proliferation, and homeostasis. Blockade or deletion of LAG-3 in autoimmune-prone backgrounds induced-disease models has been shown to exacerbate disease. We observed significantly fewer
Therapeutics that inhibit IL-6 at different points in its signaling pathway are clinical use, yet whether the immunological effects of these interventions differ based on their molecular target is unknown. We performed short-term individuals with type 1 diabetes using anti-IL-6 (siltuximab) or receptor (IL-6R; tocilizumab) therapies and investigated impact this vivo blockade T cell fate function. Immune outcomes were influenced by therapeutic intervention (IL-6 versus IL-6R) peak drug...
Elevated levels and enhanced sensing of the pro-inflammatory cytokine interleukin-6 (IL-6) are key features many autoimmune inflammatory diseases. To better understand how IL-6 signaling may influence human T cell fate, we investigated relationships between components IL-6R complex, pSTAT responses, transcriptomic translational changes in CD4 + CD8 subsets from healthy individuals after exposure to IL-6. Our findings highlight striking heterogeneity mbIL-6R gp130 expression IL-6-driven...
Abstract The co-inhibitory receptor lymphocyte activation gene 3 (LAG-3) is an immune checkpoint molecule that negatively regulates T cell activation, proliferation, and homeostasis. Blockade or deletion of LAG-3 in autoimmune-prone backgrounds induced-disease models has been shown to exacerbate disease. We observed decreased surface expression on cells subjects with rheumatoid arthritis (n=35), type 1 diabetes (n=105), relapsing-remitting multiple sclerosis (RRMS; n=121) as compared age...