M Kahvegian

ORCID: 0000-0003-1801-5633
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About
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Research Areas
  • Veterinary Pharmacology and Anesthesia
  • Respiratory Support and Mechanisms
  • Anesthesia and Sedative Agents
  • Sepsis Diagnosis and Treatment
  • Anesthesia and Pain Management
  • Blood transfusion and management
  • Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Retinal Development and Disorders
  • Intensive Care Unit Cognitive Disorders
  • Pituitary Gland Disorders and Treatments
  • Adrenal and Paraganglionic Tumors
  • Airway Management and Intubation Techniques
  • Healthcare Regulation
  • Meat and Animal Product Quality
  • Cardiac and Coronary Surgery Techniques
  • Renal function and acid-base balance
  • Lymphatic System and Diseases
  • Neuroblastoma Research and Treatments
  • Electrical and Bioimpedance Tomography
  • Pain Mechanisms and Treatments
  • Phytochemistry Medicinal Plant Applications
  • Mechanical Circulatory Support Devices
  • Hormonal and reproductive studies
  • Inflammatory mediators and NSAID effects

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2010-2015

Universidade Cruzeiro do Sul
2012-2014

Universidade de São Paulo
2007-2014

University of Antwerp
2010

Hospital Universitário da Universidade de São Paulo
2009-2010

Sociedade Brasileira de Anestesiologia
2004

Abstract Objective —To compare analgesic effects of tramadol, codeine, and ketoprofen administered alone in combination their on concentrations blood glucose, serum cortisol, interleukin (IL)-6 dogs undergoing maxillectomy or mandibulectomy. Animals —42 with oral neoplasms. Procedures —30 minutes before the end surgery, received SC injections tramadol (2 mg/kg), codeine + ketoprofen, (at aforementioned dosages). Physiologic variables, analgesia, sedation were measured (baseline) 1, 2, 3, 4,...

10.2460/ajvr.71.9.1019 article EN American Journal of Veterinary Research 2010-09-01

A variety of analgesic agents are available, and which one can be used in dogs cats is a highly controversial issue, existing however fear the use opiates due to possible adverse effects that these drugs cause. The aim this study was compare effect provided by administration tramadol or pethidine on early postoperative pain undergoing ovariohysterectomy double-blind prospective study. Fourty-two animals were randomly assigned into three groups. Pet received (6 mg/kg), Tra 2 (2 mg/kg) 4 (4...

10.1186/s12917-014-0252-1 article EN cc-by BMC Veterinary Research 2014-10-13

Acute postsurgical pain is of great interest due to potential risk becoming chronic if not treated properly, worsening patient's recovery and quality life. Twenty-eight dogs with ruptured cruciate ligaments were divided into three groups that received intramuscular injections 4 mg/kg tramadol (TRA), 0.5 methadone (MET0.5), or 0.7 (MET0.7). Physiological parameters (heart respiratory rates blood pressure) evaluated at specified times: baseline (TBL), 1 (T1), 2 (T2), (T4), 6 (T6), 24 (T24)...

10.1186/s12917-014-0194-7 article EN cc-by BMC Veterinary Research 2014-09-05

OBJECTIVES: Hypertonic saline has been proposed to modulate the inflammatory cascade in certain experimental conditions, including pulmonary inflammation caused by inhaled gastric contents.The present study aimed assess potential anti-inflammatory effects of administering a single intravenous dose 7.5% hypertonic an model acute lung injury induced hydrochloric acid.METHODS: Thirty-two pigs were anesthetized and randomly allocated into following four groups: Sham, which received anesthesia...

10.6061/clinics/2015(08)08 article EN cc-by Clinics 2015-08-01

To determine whether dexmedetomidine aggravates hemodynamic, metabolic variables, inflammatory markers, and microcirculation in experimental septic shock.Twenty-four pigs randomized into: Sham group (n = 8), received saline; Shock an intravenous infusion of Escherichia coli O55 (3 × 109 cells/mL, 0.75 mL/kg, 1 hour); Dex-Shock bacteria (bolus 0.5 mcg/kg followed by 0.7 mcg/kg/h). Fluid therapy and/ornorepinephrine were administered to maintain a mean arterial pressure > 65 mmHg. Hemodynamic,...

10.1590/acb370703 article EN cc-by Acta Cirúrgica Brasileira 2022-01-01

Being the commonest ocular disorder, dense cataracts disable fundoscopic examination and diagnosis of retinal disorders, which dogs may be predisposed. The aim this study was to compare electroretinographic responses recorded according International Society for Clinical Electrophysiology Vision human protocol evaluate function diabetic non dogs, both presenting mature or hypermature cataracts. Full-field electroretinogram from 66 with ages varying 6 15 years old allocated into two groups:...

10.1590/s0100-736x2010001200012 article EN cc-by-nc Pesquisa Veterinária Brasileira 2010-12-01

Electrical impedance tomography (EIT) is a promising bedside tool for monitoring regional lung ventilation during mechanical [1]. The purpose of this study was to assess by EIT in pig model acid-induced acute injury (ALI) pressure-controlled (PCV) and volume-controlled (VCV).

10.1186/cc8406 article EN cc-by Critical Care 2010-03-01

To date there is poor evidence that documents the benefit of red blood cell transfusion on clinical outcome. Acceptance a lower trigger in perioperative period requires detailed information regarding effects volume replacement different organs and systems. Since fluids can have widely divergent impact immune response, this study was undertaken to determine cytokine levels model acute isovolemic anemia (AIA) with hydroxyethyl starch (HES) gelatin (GEL).

10.1186/cc8612 article EN cc-by Critical Care 2010-03-01

Eletrorretinograma (ERG) é o meio diagnóstico objetivo e não-invasivo para avaliar a função retiniana detectar precocemente, em várias espécies, lesões nas suas camadas mais externas. As indicações comuns ERG cães são: avaliação pré-cirúrgica de pacientes com catarata, caracterização distúrbios que causam cegueira, além servir como importante modelo estudo da distrofia acomete homem. Vários são os fatores podem alterar tais como: eletrorretinógrafo, fonte estimulação luminosa, tipo do...

10.1590/s0100-736x2010000900009 article PT cc-by Pesquisa Veterinária Brasileira 2010-09-01

The use of dexmedetomidine to achieve sedation, analgesia and mechanical ventilation has increased in critically ill patients, although little is known about its effects septic shock. aim this study was assess hemodynamic, metabolic inflammatory a pig model

10.1186/cc9774 article EN cc-by Critical Care 2011-02-01

Em cães, a comprovação da real viabilidade pneumonectomia direita, bem como, o estudo das complicações resultantes deste procedimento cirúrgico, tornam-se importantes diante pequena quantidade de estudos na literatura específicos sobre nesta espécie. O objetivo trabalho foi realizar um experimental para avaliar direita em através avaliação paramétrica, hemogasométrica e radiográfica Foram utilizados 10 cães adultos, sadios, machos fêmeas sem raça definida, pesando entre 13 32 kg. Todos os...

10.1590/s0100-736x2007001100001 article PT cc-by-nc Pesquisa Veterinária Brasileira 2007-11-01

Controversy exists over the possible beneficial effects of hypertonic saline (HS) in pulmonary inflammatory response, particularly neutrophil immunomodulation [1,2]. This study was designed to investigate benefits HS treatment pigs submitted experimental acute lung injury.

10.1186/cc8431 article EN cc-by Critical Care 2010-03-01

The purpose of this study was to evaluate the possibility producing circulatory arrest by occlusion pulmonary trunk as an alternative venous inflow through left hemithorax. Eight healthy mongrel dogs were divided in two groups. Group I underwent 4 minutes outflow and II submitted 8 arrest. Outflow performed thoracotomy pericardiotomy passing a Rumel tourniquet around trunk. Physical examination, electrocardiography, echocardiography, blood gas analyses, hemodynamic, oxygen transport...

10.1590/s0100-736x2009000200009 article EN cc-by Pesquisa Veterinária Brasileira 2009-02-01

Hydrogen sulfide is produced endogenously by a variety of enzymes involved in cysteine metabolism.Clinical data indicate that endogenous levels hydrogen are diminished various forms cardiovascular diseases.The aim the current study was to investigate effects supplementation on cardiac function during reperfusion clinically relevant experimental model cardiopulmonary bypass.Twelve anesthetized dogs underwent hypothermic bypass.After 60 minutes arrest, started after application either saline...

10.1186/cc5200 article EN cc-by Critical Care 2007-03-01
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