A5070943117- Cannabis and Cannabinoid Research
- Biochemical effects in animals
- Migraine and Headache Studies
- Neuroscience of respiration and sleep
- Alcohol Consumption and Health Effects
- Neurotransmitter Receptor Influence on Behavior
- Connexins and lens biology
- Thermal Regulation in Medicine
- Coenzyme Q10 studies and effects
- Angiogenesis and VEGF in Cancer
- Forensic Toxicology and Drug Analysis
- Free Radicals and Antioxidants
- Platelet Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Trigeminal Neuralgia and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Complement system in diseases
- Dietary Effects on Health
- Neonatal and fetal brain pathology
- Peripheral Neuropathies and Disorders
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Vascular Malformations Diagnosis and Treatment
University of Arizona
2020-2025
Banner - University Medical Center Tucson
2022
Phoenix Neurological Associates
2017
Several chronic pain disorders, such as migraine and fibromyalgia, have an increased prevalence in the female population. The underlying mechanisms of this sex-biased yet to be thoroughly documented, but could related endogenous differences neuromodulators networks, including endocannabinoid system. cellular system comprises lipid signals 2-AG (2-arachidonoylglycerol) AEA (anandamide); enzymes that synthesize degrade them; cannabinoid receptors. relative different components specific brain...
Abstract The endocannabinoid system's significance in maintaining blood–brain barrier (BBB) integrity under physiological and pathological conditions is suggested by several reports, but the underlying molecular mechanisms are not well understood. In this paper, we investigated effects of depletion 2‐arachidonoylglycerol (2‐AG), one main endocannabinoids central nervous system, on BBB using pharmacological tools. Female Sprague–Dawley rats were injected with diacylglycerol lipase α (DAGLα)...
Introduction The high prevalence and severe symptoms of migraines in humans emphasizes the need to identify underlying mechanisms that can be targeted for therapeutic benefit. Clinical Endocannabinoid Deficiency (CED) posits reduced endocannabinoid tone may contribute migraine development other neuropathic pain conditions. While strategies increase levels n-arachidonoylethanolamide have been tested, few studies investigated targeting more abundant endocannabinoid, 2-arachidonoylgycerol, as...
Recent findings suggested that Clinical Endocannabinoid Deficiency underlies the pathophysiology of pain disorders, including migraine and headache. In models medication overuse headache induced by sustained administration sumatriptan or morphine, 2-AG levels were selectively depleted in periaqueductal gray (PAG) anandamide (AEA) increased cortex suggesting distinct regulation endocannabinoid system during pain. These results led to hypothesis blockade DAGL, reduce would induce headache-like...
Introduction: An escalating number of fatalities resulting from accidental opioid overdoses typically attributed to respiratory depression continue define the epidemic. Opioid results a decrease in reflexive inspiration within preBötzinger complex brainstem. Objective: Cannabinoid receptor agonism is reported enhance analgesia, yet whether cannabinoids or inhibit opioid-induced unknown. Methods: Studies herein sought roles cannabinoid-1 (CB1R) and cannabinoid-2 (CB2R) on using selective...
ABSTRACT Introduction: For patients receiving intravenous immunoglobulin (IVIg), renal and hemolytic side effects are well recognized. However, there very few data on the of chronic IVIg therapy. Methods: We retrospectively analyzed laboratory 166 who received for 12 months with a dose range 0.441–2.58 g/kg/month, measuring changes in hematocrit glomerular filtration (GFR) rates at 6 months. Results: Of 2,232 infusions, were no incidents clinical hemolysis. after treatment, 21% had ≥3‐g/dl...
Cortical spreading depression (CSD) is a pathophysiological mechanism underlying headache disorders, including migraine. Blood-brain barrier (BBB) permeability increased during CSD. Recent papers have suggested that heat shock proteins (HSP) contribute to the integrity of blood-brain barrier. In this study, possible role HSP90 in CSD-associated leak at endothelial cell was investigated using an vitro model, for blood-endothelial (BEB), and vivo model with intact BBB. We measured trans...
Background: Mounting evidence supports the role of endocannabinoid system in neurophysiology, includ-ing blood-brain barrier (BBB) function. Recent work has demonstrated that activation re-ceptors can mitigate insults to BBB during neurological disorders, like traumatic brain injury, cortical spreading depression and stroke. As alterations are associated with worsening clinical outcomes these conditions, studies herein sought examine impact depletion on integrity. Methods: Barrier integrity...
Mounting evidence supports the role of endocannabinoid system in neurophysiology, including blood-brain barrier (BBB) function. Recent work has demonstrated that activation receptors can mitigate insults to BBB during neurological disorders like traumatic brain injury, cortical spreading depression, and stroke. As alterations are associated with worsening clinical outcomes these conditions, studies herein sought examine impact depletion on integrity. Barrier integrity was investigated vitro...
To determine the nephrotoxic and hemolytic side effects of chronic high dose IVIG therapy.
Cortical spreading depression (CSD) is a pathophysiological mechanism underlying headache disorders, including migraine. Blood-brain barrier (BBB) permeability increased during CSD. Recent papers have suggested that heat-shock proteins (HSP) contribute to the integrity of blood-brain barrier. In this study, possible role HSP90 in CSD-associated leak at endothelial cell was investigated using an vitro model, for blood (BEB), and vivo model with intact BBB. We measured trans electric...
This study examines the roles of 2-AG hydrolyzing enzymes MAGL and ABHD6 as they pertain to headache development within KCl model migraine. We seek further our understanding how modulation endocannabinoid system may underlie migraine development.
Abstract Background: Several chronic pain disorders, such as migraine and fibromyalgia, have an increased prevalence in the female population. The underlying mechanisms of this sex-biased yet to be thoroughly documented but could related endogenous differences neuromodulators networks, including endocannabinoid system. cellular system is comprised lipid signals 2-AG (2-arachidonoylglycerol) AEA (anandamide); enzymes that synthesize degrade them; cannabinoid receptors. relative different...
This study examines the role of DAGL in headache development. We investigate exogenous inhibition as a novel route to recapitulate clinical features episodic headache.