A5012305982- Developmental Biology and Gene Regulation
- Mosquito-borne diseases and control
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Congenital heart defects research
- Viral Infections and Vectors
- Nerve injury and regeneration
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Wnt/β-catenin signaling in development and cancer
- Neurogenesis and neuroplasticity mechanisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Insect Pest Control Strategies
- Pain Mechanisms and Treatments
- RNA Interference and Gene Delivery
- Malaria Research and Control
- Pancreatic function and diabetes
- Congenital gastrointestinal and neural anomalies
- Insect symbiosis and bacterial influences
- Hypothalamic control of reproductive hormones
- Neuroscience and Neuropharmacology Research
- Neuroblastoma Research and Treatments
- Epigenetics and DNA Methylation
- Hedgehog Signaling Pathway Studies
- Ubiquitin and proteasome pathways
- Genomic variations and chromosomal abnormalities
University of Fribourg
2016-2023
University of Freiburg
2009-2018
Bernhard Nocht Institute for Tropical Medicine
2012-2017
Institute of Geodesy and Cartography
2015
Heidelberg University
1996-2012
University of St Andrews
2000
Medical University of Vienna
1989
To monitor adult mosquitoes several trapping devices are available. These differently constructed and use various mechanisms for mosquito attraction, thus resulting in different sensitivities efficacies the species. Mosquito monitoring surveillance programs Europe types of traps, but only a few comparisons have been conducted so far. This study compared performance four commercial devices, which commonly used Europe. Four Biogents Sentinel trap (BG trap), Heavy Duty Encephalitis Vector...
The sympathoadrenal (SA) cell lineage is a derivative of the neural crest (NC), which gives rise to sympathetic neurons and neuroendocrine chromaffin cells. Signals that are important for specification these two types cells largely unknown. MASH1 plays an role neuronal as well catecholaminergic differentiation. Mash1 knockout mice display severe deficits in ganglia, yet their adrenal medulla has been reported be normal suggesting essential but not We show now function necessary development...
The emerging bunyavirus Rift Valley fever virus (RVFV) is transmitted to humans and livestock by a large number of mosquito species. RNA interference (RNAi) has been characterized as an important innate immune defense mechanism used mosquitoes limit replication positive-sense flaviviruses togaviruses; however, little known about its role against negative-strand viruses such RVFV. We show that virus-specific small RNAs are produced in infected cells, Drosophila melanogaster and, most...
The neural crest (NC) is a transient embryonic structure unique to vertebrates, which generates peripheral sensory and autonomic neurons, glia, neuroendocrine chromaffin thyroid C-cells, melanocytes, mesenchymal derivatives such as parts of the skull, heart, meninges. sympathoadrenal (SA) cell lineage one major sub-lineage NC that gives rise sympathetic cells, intermediate small intensely fluorescent (SIF) cells. A key question when during ontogeny do multipotent progenitors segregate into...
The diversification of neural-crest-derived sympathoadrenal (SA) progenitor cells into sympathetic neurons and neuroendocrine adrenal chromaffin was thought to be largely understood. In-vitro studies with isolated SA had suggested that cell differentiation depends crucially on glucocorticoids provided by cortical cells. However, analysis mice lacking the glucocorticoid receptor gene revealed develop mostly normally in these mice. Alternative cues from cortex may promote determination have...
Neuroendocrine chromaffin cells exist in both intra- and extra-adrenal locations; the organ of Zuckerkandl (OZ) constitutes largest accumulation tissue mammals. The OZ disappears postnatally by modes that are still enigmatic but can be maintained treatment with glucocorticoids (GC). Whether response to GC reflects a pharmacological or physiological role has not been clarified. Using mice conditional deletion GC-receptor (GR) gene restricted expressing dopamine β-hydroxylase (DBH) [GR(fl/fl)...
Islet-1 is a LIM-Homeodomain transcription factor with important functions for the development of distinct neuronal and non-neuronal cell populations. We show here that acts genetically downstream Phox2B in cells sympathoadrenal lineage sympathetic neurons chromaffin impaired mouse embryos conditional deletion controlled by wnt1 promotor. not essential initial differentiation cells, as indicated correct expression pan-neuronal catecholaminergic subtype specific genes primary ganglia...
Aedes (Finlaya) japonicus (Theobald, 1901) [Hulecoeteomyia japonica sensu] (Reinert et al. 2006) is one of four morphologically similar subspecies the Asian bush or rock pool mosquito that prevalent throughout Japan, Korea, Taiwan, eastern China, and Russia (Tanaka 1979). First reports Ae. j. outside its endemic area were from New Zealand where was introduced via transoceanic containers carrying used tires Japan (Laird 1994). In 1998, species discovered in northeastern United States (Peyton...
Abstract The search for signalling systems regulating development of noradrenergic and cholinergic sympathetic neurons is a classical problem developmental neuroscience. While an essential role bone morphogenetic proteins induction properties firmly established, factors involved in the traits vivo are still enigmatic. Previous studies have shown that c‐ret receptor coexpressed chick neurons. Using situ hybridization we show now loss‐of‐function mutation mice dramatically reduces numbers...
The adrenal medulla receives its major presynaptic input from sympathetic preganglionic neurons that are located in the intermediolateral (IML) column of thoracic spinal cord. neurotrophic factor concept would predict these IML receive trophic support chromaffin cells medulla. We show here adult rat store neurotrophin (NT)-4, but do not synthesize or detectable levels BDNF NT-3, respectively. Preganglionic to identified by retrograde tracing with fast blue Fluoro-Gold (FG) express TrkB mRNA....
Abstract Background Adrenal chromaffin cells and sympathetic neurons both originate from the neural crest, yet signals that trigger development remain elusive. Bone morphogenetic proteins (BMPs) emanating dorsal aorta are important for induction of a sympathoadrenal catecholaminergic cell fate. Results We report here BMP-4 is also expressed by adrenal cortical throughout chick embryonic development, suggesting putative role in development. Moreover, bone protein receptor IA cells. Inhibiting...
TrkA high-affinity receptors are essential for the normal development of sympathetic paravertebral neurons and subpopulations sensory neurons. Paravertebral chromaffin cells adrenal medulla share an ontogenetic origin, responsiveness to NGF, expression TrkA. Which aspects might be regulated via unknown. In present study we demonstrate that mice deficient TrkA, but not neurotrophin receptor TrkB, show early postnatal progressive reduction acetylcholinesterase (AChE) enzymatic activity in...