A5041329386- Hearing, Cochlea, Tinnitus, Genetics
- Neuroscience of respiration and sleep
- Tracheal and airway disorders
- Hearing Loss and Rehabilitation
- Peptidase Inhibition and Analysis
- Neonatal and fetal brain pathology
- Obstructive Sleep Apnea Research
- Noise Effects and Management
- Head and Neck Cancer Studies
- Ear and Head Tumors
- Tumors and Oncological Cases
- Head and Neck Surgical Oncology
- Vestibular and auditory disorders
- Cancer Diagnosis and Treatment
- Human Health and Disease
- Oral and Maxillofacial Pathology
- Neuroendocrine Tumor Research Advances
- Assisted Reproductive Technology and Twin Pregnancy
- Oral Health Pathology and Treatment
- Ovarian cancer diagnosis and treatment
- Congenital heart defects research
- Neuropeptides and Animal Physiology
- Vascular Malformations and Hemangiomas
- Protease and Inhibitor Mechanisms
- IgG4-Related and Inflammatory Diseases
University of the Basque Country
2013-2024
Hospital de Basurto
2012-2024
Osakidetza
2021-2024
BioCruces Health research Institute
2021
Indiana University School of Medicine
2007
Hospital de Cruces
1989-1993
New York Medical College
1971
Background Over the last few years, ultrasonography has been introduced as fifth pillar to patient’s bedside physical examination. Clinical assessments aim screen and look for airway difficulties predict difficult intubations, but none have demonstrated a significant predictive capacity. Recent systematic reviews established correlation between ultrasound imaging direct laryngoscopy. The primary objective of this study was determine whether utilization examine upper could accurately Methods...
SANTAOLALLA F., ANTA J.A., ZABALA A., DEL REY SANCHEZ MARTINEZ A. & J.M. (2010) European Journal of Cancer CareManagement chylous fistula as a complication neck dissection: 10-year retrospective review Chylous is serious surgery. The aim this study was to analyse the incidence, treatment and evolution in dissection. We conducted 304 patients, 295 (97.03%) men nine (2.97%) women. Ages ranged from 24 80 years (mean = 59.28 years, SD 6.02) they had all undergone occurred four cases (1.31%)....
Abstract Background. Involvement of peptidases in carcinogenic processes several tumor types has been investigated recent years. Head and neck squamous cell carcinoma (HNSCC) is one the most common cancers worldwide accounts for more than 90% all head cancers. Increased understanding its pathophysiology led to implication proteinases, specially matrix metalloproteinases, genesis, growth, dissemination. However, very little known about involvement this neoplasm. Methods. Seventeen HNSCC...
Early diagnosis of laryngeal squamous cell carcinoma (LSCC) at the stage dysplasia could greatly improve outcome affected patients. For first time we compared mutational landscape non-progressing (NPD; n = 42) with progressing (PD; 24), along patient-matched LSCC biopsies; a total 90 samples. Using targeted next-generation sequencing identified non-synonymous mutations in six genes (PIK3CA, FGFR3, TP53, JAK3, MET, FBXW7), and were validated by Sanger and/or qPCR. Analysis was extended silico...
Delta-like proteins 1 and 2 (DLK1, 2) are NOTCH receptor ligands containing epidermal growth factor-like repeats, which regulate signalling. We investigated the role of DLK pathway in morphogenesis submandibular salivary glands (SMGs), using vitro organotypic cultures.DLK1 were present all stages SMG morphogenesis, where DLK1 inhibited both activity branching. The addition inhibitory agents, either soluble (sDLK1) or N-[N-(3, 5-difluorophenacetyl-L-alanyl]-S-phenylglycine t-buthyl ester...
Percutaneous embolization reduces the reappearance of epistaxis and mean length hospital stay for patients with intractable or juvenile nasopharyngeal angiofibroma (JNA).To assess whether percutaneous is effective treatment JNA.Twenty-eight posterior treated by (25 males; m = 59.78 years; SD 14.3) 28 unembolized (24 59.21 15.13) were studied retrospectively. Eight JNA (all 16.5 2.35; four embolized before surgery unembolized) also analyzed.Embolization was bilateral in 71.4% subjects, blood...
Conclusion: A reduction in the percentage of correct responses olfactory test indirectly indicated increased albuminuria and worse glomerular filtration rate (GFR) diabetic patients. The function is an indirect indicator early microvascular complications Objectives: Diabetes mellitus a highly prevalent disease that causes numerous complications. aim this study was to determine whether taste sensations are related renal failure Methods: We studied 61 patients diagnosed with diabetes mellitus,...
The normal nasal lymphatic drainage runs via the facial vessels into neck nodes of levels I-II and this pattern was found in our patients with sinonasal tumors. We only one true-positive sentinel lymph node (SLN). Our pathological material very limited so further investigations are required before any valid conclusions can be drawn concerning clinical value SLNs Objectives. To detect collection route fossae paranasal sinuses to identify first echelon tumor metastatic cascade order prevent...
A multi-centre trial using PET requires the analysis of images acquired on different systems We designed a to estimate value 18F-FLT-PET predict response neoadjuvant chemotherapy in patients with newly diagnosed breast cancer. calibration check each PET-CT and its peripheral devices was performed evaluate reliability results. Material Methods 11 centres were investigated. Dose calibrators assessed by repeated measurements 68Ge certified source. The differences between clocks associated dose...
Inflammatory myofibroblastic tumor (IMFT) of the temporal bone is an unusual but distinct clinicopathologic entity.We report case a 75-year-old patient with IMFT located in bone. Symptoms included VI, X, XI, and XII cranial nerves palsies. Computed tomography magnetic resonance images are described. The lesion was locally aggressive outcome fatal. identified by analysis postmortem specimen histopathologic immunohistochemical confirmation.IMFT can be destructive lesions. Involvement skull...
Conclusions: 1. The principle of bilateral symmetry depends on the chordal cartilage that is keystone in cranial base ossification rats and humans, due to its anatomical situation for production chordin protein regulates bone morphogenetic BMP-7. 2. In humans rats, foramen lacerum closure follows a line intramembranous BMP-7, regulated by first branchial pouch. 3. patterns centres are similar except otic capsule, palate lateral pterygoid plate. 4. neural crest may induce through nerves....
We tried to assess the relationship between nasal resistance measured by rhinomanometry and pressure used in CPAP.Retrospective medical case series review, January 2004 December 2014.Tertiary care academic centre.Thirty-eight patients (m = 56.55 years; male 90.5%) with CPAP settings ≤8 39 57.49 74.9%) ≥12.Study variables were BMI, neck circumference, Epworth Sleepiness Scale score, nasopharyngeal examination computerised anterior active rhinomanometry, sitting supine, basal conditions after...
Introduction Head and neck cancer represents 3% of all cancers is the cause 5% deaths caused by cancer. The purpose this study to evaluate implementation a screening program diagnose early phase head oncological processes. Methods We have studied 324 asymptomatic patients who had at least one major risk factor (habitual consumption tobacco or alcohol) two minor factors: family history upper aerodigestive tract, occupational exposure, poor oral hygiene Human Papillomavirus chronic...
Papillary thyroid carcinoma (PTC), follicular adenoma (FTA), and nodular hyperplasia (TNH) are the most frequent diseases of gland. Previous studies described involvement dipeptidyl-peptidase IV (DPPIV/CD26) in development neoplasia proposed it as an additional tool diagnosis/prognosis these diseases. However, very little is known about other peptidases neoplastic hyperplastic processes this The catalytic activity 10 a series 30 PTC, FTA, 14 TNH was measured fluorimetrically tumour nontumour...