A5076497988- Sports, Gender, and Society
- Genetics and Neurodevelopmental Disorders
- Gender Roles and Identity Studies
- Cellular transport and secretion
- Congenital heart defects research
- Youth Development and Social Support
- Autism Spectrum Disorder Research
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
University Medical Center of the Johannes Gutenberg University Mainz
2024
Johannes Gutenberg University Mainz
2024
University of Koblenz and Landau
2024
University of Kaiserslautern
2024
Abstract Neuroligin-2 (Nlgn2) is a key synaptic adhesion protein at virtually all GABAergic synapses, which recruits GABA A Rs by promoting assembly of the postsynaptic gephyrin scaffold. Intriguingly, loss Nlgn2 differentially affects subsets indicating that synapse-specific interactors and redundancies define its function, but nature these interactions remain poorly understood. Here we investigated how function in hippocampal area CA1 modulated two proposed interaction partners, MDGA1...
Autism spectrum disorder (ASD) is often associated with social communication impairments and specific sound processing deficits, for example, problems in following speech noisy environments. To investigate underlying neuronal defects located the auditory cortex (AC), we performed two-photon Ca2+ imaging FMR1 (fragile X messenger ribonucleoprotein 1) knock-out (KO) mice, a model fragile syndrome (FXS), most common cause of hereditary ASD humans. For primary AC (A1) anterior field (AAF),...