In the field of additive manufacturing, design and fabrication lattice structures have garnered substantial attention, particularly for their potential in advanced material applications. This study focuses on mechanical properties titanium alloy Ti64 fabricated by Laser Powder Bed Fusion. It examines features two structure types, TPMS Gyroid Stochastic Voronoi, analyzing interplay. To evaluate properties, methodologies to compute stress were employed: Method A, nominal diameter calculations...

Lovastatin (LOV) is a drug used to treat hypercholesterolemia. Recent studies have identified its antioxidant effects and potential use in the treatment of some types cancer. However, low bioavailability related poor water solubility limits solid oral dosage forms. Therefore, improve LOV three eutectic systems with carboxylic acids benzoic (BEN), salicylic (SAL) cinnamic (CIN) were obtained. Both binary phase Tammann diagrams constructed using differential scanning calorimetry (DSC) data...

Purpose This study compares the fatigue performance and biocompatibility of as-built chemically etched Ti-6Al-4V alloys in TPMS-gyroid stochastic structures fabricated via Powder Bed Fusion Laser Beam (PBF-LB). aims to understand how complex lattice post-manufacturing treatment, particularly chemical etching, affect mechanical properties, surface morphology, resistance these metamaterials for biomedical applications. Design/methodology/approach Selective Melting (SLM) technology was used...

Titanium-based lattice structures have gained significant attention in biomedical engineering due to their potential mimic bone-like behavior and improve implant performance. This study evaluates the performance of bio-inspired Ti64 TPMS Gyroyd Stochastic fabricated via Powder Bed Fusion-Laser Beam (PBF-LB), focusing on in-vivo ex-vivo mechanical biological responses for applications. Utilizing an SLM 280 HL printer, samples exhibited notable geometric accuracy essential integrity. The...

This study presents a polymeric scaffold designed and manufactured to mimic the structure mechanical compressive characteristics of trabecular bone. The morphological parameters behavior were studied compared with bone from bovine iliac crest. Its properties, such as modulus elasticity yield strength, under three-step monotonic test. Results showed that elastic was 329 MPa, one for reached 336 MPa. A stepwise dynamic test used assess samples various loading regimes. With microcomputed...

Irbesartan (IBS) is a tetrazole derivative and antihypertensive drug that has two interconvertible structures, 1H- 2H-tautomers. The difference between them lies in the protonation of ring. In solid-state, both tautomers can be isolated as crystal forms A (1H-tautomer) B (2H-tautomer). Studies have reported IBS polymorphic system its are related monotropically. These reports indicate form most stable less soluble form. Therefore, goal this contribution to demonstrate through complete...

The experimental conditions necessary for stabilising irbesartan (IBS) tautomers in solution and selectively obtaining the desmotropic crystal forms are presented herein. 1H 2H were stabilized specific 2H-tetrazole⋯imidazole interaction was confirmed by solution-state NMR. results showed that highly polar polarisable solvents (higher values of electrostatic factor (EF)) lead to crystallisation IBS form B. Furthermore, variations pH methanol, turn, determined desmotropes A and/or

Abstract In this study the compressive cyclic behavior of bovine cancellous bone and three open‐cell metallic foams including AlSi7Mg (30 45 ppi) CuSn12Ni2 foam has been investigated. Multi‐step fatigue tests are carried out to deformation under increasing stresses. Short multi‐step tests, with steps 300–500 cycles, used identify yield stress ( σ cy ) at failure fail ). The residual strain accumulation, or creep, is observed during these tests. Long 5000 cycles selected ranges (0.4 , 0.6 0.8...

Primarily composed of organic molecules, pharmaceutical materials, including drugs and excipients, frequently exhibit physicochemical properties that can affect the formulation, manufacturing packing processes as well product performance safety. In recent years, researchers have intensively developed Crystal Engineering (CE) in an effort to reinvent bioactive molecules with well-known, approved pharmacological effects. general, CE aims improve without affecting their intrinsic...

The design of new pharmaceutical solids with improved physical and chemical properties can be reached through in-detail knowledge the noncovalent intermolecular interactions between molecules in context crystal packing. Although crystallization from solutions is well-known for obtaining solids, effect some variables on not yet thoroughly understood. Among these variables, solvents are noteworthy. In this context, present study aimed to investigate ethanol (EtOH), acetonitrile (MeCN), acetone...

An appropriate and reliable sterilization technique is crucial for tissue engineering scaffolds. Skeletal muscle scaffolds are often fabricated using microfilaments of a wide variety polymers. One method 25 kGy gamma irradiation. In addition, through irradiation should administer dose within specific range. Radiation directly affects the chemical mechanical properties The accuracy effects not considered during procedures; however, these important since they provide insight on whether...

Abstract The present paper summarizes interdisciplinary experimental and theoretical research on the mechanical behavior of open‐cell AlSi7Mg α brass sponges, particularly focusing fatigue under isothermal test conditions periodically fluctuating temperature (thermomechanical TMF), latter carried out in a self‐designed chamber. Monotonic tensile compression tests were performed these metal taking into account variation homogeneity difference ductility cell strut material (AlSi7Mg brass)....

Abstract This work serves as a proof-of-concept for the application of plasma sprayed hydroxyapatite (HA) coatings on biopolymer implants. In absence conventional sprayer, coating samples were produced by manually injecting HA powder into cutting torch fitted with custom made nozzle. Using improvised setup, was successfully deposited PLA, PEEK, and PVA discs well Al Ti substrates. The characterized thermal imaging scanning electron microscopy, results are presented discussed.

Tissue engineering endeavors to create in vitro constructs that replicate the properties of native tissue, such as skeletal muscle. This study investigated use mechanical stimulation promote myogenic differentiation and enhance functionality bioengineered tissues. Specifically, it aimed facilitate myoblasts within a three-dimensional scaffold using defined pattern stimulation. C2C12 cells were cultured on collagen-coated PCL microfilament subjected 24 h uniaxial static strain biomechanical...

Polymeric scaffolds can be fabricated as microfilaments to replicate the mechanical characteristics and biological configuration of skeletal muscles tendons. The used in this research were from polycaprolactone (PCL) pellets by extrusion a spooling system without using solvents. Their properties investigated applying monotonic dynamic loads on aligned grouped customized grip adapter. fabrication method was simple produced homogeneous microfilament with 90 ± 3 µm diameter. tests showed...

El objetivo principal de este trabajo fue la fabricación filamentos alcohol polivinílico (PVA) y policaprolactona (PCL) para ser usados en impresión 3D con tecnología modelado por deposición fundida (FDM). estudio se orientó primeramente fabricar los estos biopolímeros extrusión posteriormente reforzaron internamente hidroxiapatita (HAp) así mejorar sus propiedades mecánicas. Previo al proceso manufactura, el PVA, PCL HAp caracterizaron usando difracción rayos-X evidenciar grado ordenamiento...

Tissue engineering aims to develop in-vitro substitutes of native tissues. One approach tissue relies on using bioreactors combined with biomimetic scaffolds produce study models or substitutes. Bioreactors provide control over environmental parameters, place and hold a scaffold under desired characteristics, apply mechanical stimulation scaffolds. Polymers are often used for fabricating tissue-engineering In this study, polycaprolactone (PCL) collagen-coated microfilament were cell-seeded...

<p class="p1">En este trabajo se analizaron probetas TEM (Microscopía Electrónica de Transmisión, por sus siglas en ingles) materiales usados aplicaciones aeronáuticas. El principal objetivo proyecto fue estudiar los defectos intercristalinos presentes la superaleación Nimonic 80A luego ser tratada térmicamente y posteriormente someter las a esfuerzos cíclicos. Las fueron probadas previamente bajo fatiga alta frecuencia (1 000 Hz 20 Hz) Universidad Siegen Alemania, simulando...