A5040879382- Advanced Glycation End Products research
- Natural Antidiabetic Agents Studies
- Diet, Metabolism, and Disease
- Carcinogens and Genotoxicity Assessment
- Alcohol Consumption and Health Effects
- Diabetes and associated disorders
- DNA and Nucleic Acid Chemistry
- Computational Drug Discovery Methods
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Biochemical effects in animals
- Glutathione Transferases and Polymorphisms
- Medicinal Plants and Neuroprotection
- Cholinesterase and Neurodegenerative Diseases
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Mangiferin and Mango Extracts
- Free Radicals and Antioxidants
- Gold and Silver Nanoparticles Synthesis and Applications
- Cannabis and Cannabinoid Research
- Autophagy in Disease and Therapy
- Ethnobotanical and Medicinal Plants Studies
- Antioxidant Activity and Oxidative Stress
- Adipokines, Inflammation, and Metabolic Diseases
- Machine Learning in Bioinformatics
University of Ha'il
2025
King George's Medical University
2014-2024
Aligarh Muslim University
2011-2022
Jawaharlal Nehru Medical College Hospital
2022
Central Drug Research Institute
2014-2015
Sarojini Naidu Medical College
2013
Non-enzymatic glycation is the addition of free carbonyl group reducing sugar to amino groups proteins, resulting in formation a Schiff base and an Amadori product. Dihydroxyacetone (DHA) one species which reacts rapidly with proteins form advanced end products (AGEs). The highly reactive dihydroxyacetone phosphate derivative (DHA), product glycolysis, having potential glycating effects AGEs. AGEs results generation radicals play important role pathophysiology aging diabetic complications....
Advanced glycation end-products (AGEs) are known to be mutagenic, diabetogenic and vascular disease risk factors. Methylglyoxal (MG) is a dicarbonyl species that reacts with biological macromolecule (proteins, DNA lipids) give AGEs. Nonenzymatic of MG lysine (Lys) in the presence copper (Cu(2+)) reported generate reactive oxygen (ROS) capable causing damage. We show modification MG-Lys-Cu(2+) system results generation strand breaks, base modification, hyperchromicity increased fluorescence...
Abstract Major challenges for current therapeutic strategies against breast cancer are associated with drug-induced toxicities. Considering the immense potential of bioactive phytochemicals to deliver non-toxic, efficient anti-cancer therapeutics, we performed bio-guided fractionation Eclipta alba extract and discovered that particularly chloroform fraction (CFEA) is selectively inducing cytotoxicity cells over non-tumorigenic epithelial cells. Our unbiased mechanistic hunt revealed CFEA...
Background The oxidation of proteins by endogenously generated free radicals causes structural modifications in the molecules that lead to generation neo-antigenic epitopes have implications various autoimmune disorders, including rheumatoid arthritis (RA). Collagen induced (CIA) rodents (rats and mice) is an accepted experimental model for RA. Methodology/Principal Findings Hydroxyl were Fenton reaction. type II (CII) was modified •OH radical (CII-OH) analysed ultraviolet-visible (UV-VIS),...
Hundreds of millions people around the globe are afflicted by diabetes mellitus. The alteration in glucose fixation process might result into hyperglycaemia and could affect circulating plasma proteins to undergo nonenzymatic glycation reaction. If it is unchecked, may lead with increase advanced end products (AGEs). Therefore, present study was designed inhibit using natural antioxidant "ellagic acid" (EA). In this study, we explored antidiabetes antiglycation potential EA both vitro (EA at...
4‐Aminobiphenyl (4‐ABP), an aromatic amine is a major environmental carcinogen found mainly in cigarette smoke. It has been vastly implicated mutagenesis and cancer development. In this study, commercially available human placental DNA was exposed to 4‐ABP (1.3 mM) presence of sodium nitroprusside (SNP; 8 at 37°C for 3 h. The + SNP‐mediated structural changes were studied by ultraviolet, circular dichroism fluorescence spectroscopy, thermal melting profile, agarose gel electrophoresis,...