Abstract Treatment patterns and outcomes are unclear for metastatic breast cancer (MBC) patients diagnosed with hormone receptor-positive (HR+), human epidermal growth factor 2-positive (HER2+) disease. This study aimed to: (1) examine the utilization of first-line therapy among HR+/HER2+/MBC (2) compare overall survival (OS) between identified regimens. We analyzed National Cancer Database (HR+/HER2+/MBC) who were treated 2010 2015. Multivariable logistic Cox regression used identify...

Exemestane (EXE), an irreversible aromatase inhibitor, is employed as a therapy for hormone-dependent breast cancer. Several studies have also established the budding effects of genistein (GEN) in various types cancer such breast, prostate, well skin due to its feeble estrogenic and anti-estrogenic properties. Considering promising benefits GEN, it was combined with EXE accomplish superior therapeutic efficiency fewer side effects. The quantification exact concentration GEN when delivered...

Gemcitabine (dFdC) mediated cancer treatment faces obstacles, due to its high hydrophilicity. A valuable strategy was executed by synthesizing lipophilic fatty acid derivative of dFdC i.e., 4-(N)-stearoyl gemcitabine (C18dFdC), built-in into polymeric poly-lactic-co-glycolic nanoparticles (PLGA NPs) and compared with that parent drug. Encapsulation within NPs higher (68.24 +/- 3.64%) than showed comparatively sustained drug release (19.87 1.73% 12 hours), a proof increased biological half...

Docetaxel (DTX) is favoured option for breast cancer treatment; however its marketed formulation (Taxotere) generates therapeutic response at the cost of undue toxicity. In order to circumvent such limitations, DTX nanocrystals (DTX-NCs) were prepared through high pressure homogenization (HPH) technique using pluronic F-127 (PF-127) as a stabilizer. DTX-NCs presented higher efficacy against MCF-7 cells with exposition 1.75 and 2.13 fold lower inhibitory concentration (IC50) compared free...

Objective: To undertake metabolite profiling of various plant parts Citrullus colocynthis, and assess antioxidant wound healing activities fractions for therapeutical applications. Methods: Extracts from leaves, stem, root, fruit pulp seeds were analyzed using gas chromatography-mass spectrometry high performance liquid chromatography. Variation in potential was assayed by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay. The extract with highest subjected on in-vivo...

The purpose of the current study was to prepare and evaluate a citronella oil-loaded microemulsion-based micro-emulgel for treatment Candida albicans. primary objective use skin transfer hydrophobic medications into bloodstream. formulation included cinnamon oil as an antifungal active pharmaceutical ingredient, respectively. Tween 80 PEG 200 were used surfactant co-surfactant, respectively, create phase diagrams. Carbopol 940, one frequently polymers, investigated its ability gel...

Background: Pazopanib hydrochloride (PZB) is a protein kinase inhibitor approved by the United States Food and Drug Administration European agencies for treatment of renal cell carcinoma other malignancies. However, it exhibits poor aqueous solubility inconsistent oral drug absorption. In this regard, current research work entails development evaluation extrudates pazopanib hot-melt extrusion (HME) technique enhancement augmenting bioavailability. Results: Solid dispersion was prepared using...

The present study describes the development and validation of a simple rapid HPLC method for simultaneous quantification exemestane thymoquinone. separation both compounds was performed on 5 μ C-18 column utilizing phase A as water/methanol (45:5 v/v) B acetonitrile (50 (total ratio A/B = 40:60 in isocratic elution mode mobile at flow rate 0.8 mL/min. Further, Box–Behnken design used optimizing analytical method. proposed validated various parameters, all parameters were found to be within...

The primary and secondary metabolites of different parts Aegle marmelos were isolated, the cyclic polyols characterized. antioxidant activities in vitro a cell-based human liver AML-12 cells anti-inflammatory isolated quinic acid ethanol extract leaves determined. One hundred thirty two identified extracts by HPLC, GC-MS, NMR. Results demonstrated A. as an sustainable by-product with therapeutic potential for treating inflammation.

e19530 Background: Breast cancer patients (pts) have limited options for the treatment of hot flashes. A recent clinical observation (Smith TJ, J Clin Oncol. 2009 Mar 1;27(7):1151-2. Epub Jan 26) has suggested a potential role oral magnesium in management menopausal The aim this pilot trial was to assess efficacy and safety oxide flashes patient population. Methods: Prospective evaluation. average number per day reported by each pt recorded before after 4 weeks (400 mg TID). Results: Between...

Rheumatoid arthritis, a chronic autoimmune disorder affecting millions worldwide each year, poses significant threat due to its potential for progressive joint damage and debilitating pain if left untreated. Topical anti-inflammatory analgesic treatments offer localized relief with reduced systemic side effects compared conventional oral therapies, making them promising option managing rheumatoid arthritis. Therefore, the current study endeavored formulate microemulsion gel formulation...

1033 Background: Treatment patterns and clinical outcomes are unclear for MBC patients diagnosed with estrogen receptor-positive (ER+) and/or progesterone (PR+) human epidermal growth factor 2 positive (HER2+) disease (i.e. triple positive). This study aimed to: 1) examine the utilization of first-line therapy among ER+/PR+/HER2+ 2) compare overall survival (OS) between identified regimens. Methods: We analyzed included in National Cancer Database who were treated endocrine (ET) or...

Amaranthus (family Amaranthaceae) is a potentially nutritious pseudocereal also known as functional food owing to its high nutritional quality grains especially rich in essential amino acids. Emerging study, however, unambiguously indicates that apart from nutrients like protein, other phytochemicals present amaranth seeds provide excellent health benefits. Squalene one such phytonutrient found seeds, which largest vegetal source. In this research work, GC-MS and NMR spectroscopy-based...

Abstract Cannabis is one of the most consumed illicit drugs and potency cannabis products note due to health‐related concerns. Hand‐rubbed hashish ancient technique extracting psychoactive resin from plants practiced in Indian Himalayas. This study establishes cannabinoid profile hand‐rubbed collected 20 regions northwest Fifty‐eight samples were analyzed using a validated high‐performance liquid chromatography‐diode array detection (HPLC‐DAD) method. Ten cannabinoids quantified including...

A solid pancreatic mass is found to be malignant 95% of the time, while inflammation accounts for remaining cases. We report a case granulomatosis with polyangiitis (GPA) presenting as an inflammatory initially suspected metastatic cancer. This 73-year-old male who presented ED weakness, fevers, night sweats, and weight loss. His medical history was significant severe chronic sinusitis nasal polyps. On physical examination, he noted have bilateral lower extremity nodular purple plaques...

1032 Background: Determinants of variation in therapy utilization and OS are unclear for patients diagnosed with hormone receptor+, human epidermal growth factor 2 positive (HER2+) MBC. This study aimed to identify if there disparities first-line treatment patterns outcomes this subpopulation MBC patients. Methods: We analyzed included the National Cancer Database estrogen receptor-positive (ER+) and/or progesterone (PR+) HER2+ disease (i.e. triple positive) treated endocrine or chemotherapy...

Abstract Introduction: There is a growing interest in understanding the concerns of patients undergoing cancer therapy. Many share their experiences on online support forums, which contain millions freely shared messages that can be used to analyze patient concerns. Unfortunately, these data are unstructured, makes them difficult analyze. In this project we organize forums using methods from Big Data Science (BDS), and then by creating Decision Support System (DSS): an interactive interface...