A5064427110- Multiple Sclerosis Research Studies
- Genetic Neurodegenerative Diseases
- Vestibular and auditory disorders
- Hereditary Neurological Disorders
- Botulinum Toxin and Related Neurological Disorders
- Ophthalmology and Eye Disorders
- Genomics and Rare Diseases
- Myasthenia Gravis and Thymoma
- Glaucoma and retinal disorders
- Inflammatory Myopathies and Dermatomyositis
- Ocular Surface and Contact Lens
- Stroke Rehabilitation and Recovery
- Fibroblast Growth Factor Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Polyomavirus and related diseases
- Peripheral Neuropathies and Disorders
- Mesenchymal stem cell research
- Hearing, Cochlea, Tinnitus, Genetics
- Trigeminal Neuralgia and Treatments
- Salivary Gland Disorders and Functions
- Intracranial Aneurysms: Treatment and Complications
- Epilepsy research and treatment
- Peripheral Nerve Disorders
- Cardiomyopathy and Myosin Studies
- Cerebrovascular and genetic disorders
Wellington Hospital
2015-2023
The Royal Melbourne Hospital
2020-2021
Capital and Coast District Health Board
2016-2017
ABSTRACT Introduction Sensory impairment in Friedreich ataxia (FRDA) is generally accepted as being due to a ganglionopathy. The degree of contribution from axonal pathology remains matter debate. Nerve ultrasound may be able differentiate these processes. Methods cross‐sectional area median, ulnar, tibial, and sural nerves 8 patients with FRDA was compared age‐ gender‐matched healthy controls reference values our population. Results the were significantly larger than those at all upper limb...
Mortality data from Europe and North America show a shorter life expectancy for people with multiple sclerosis (MS). It is not known if similar mortality risk exists in the southern hemisphere. We analysed outcomes of comprehensive New Zealand (NZ) MS cohort, 15 years postrecruitment.All participants nationwide 2006 NZ prevalence study were included compared table population using classic survival analyses, standardised ratios (SMRs) excess death rates (EDRs).Of 2909 participants, 844 (29%)...
Because clozapine and risperidone have been shown to reduce neuroinflammation in humans mice, the Clozapine Risperidone Progressive Multiple Sclerosis (CRISP) trial was conducted determine whether are suitable for progressive multiple sclerosis (pMS).The CRISP (ACTRN12616000178448) a blinded, randomised, placebo-controlled with three parallel arms (n=12/arm). Participants pMS were randomised (100-150 mg/day), (2.0-3.5 mg/day) or placebo 6 months. The primary outcome measures safety (adverse...
Objectives: To determine the incidence of gentamicin vestibulotoxicity with current dosing regimens, and to evaluate feasibility routine video-oculography on all patients given gentamicin.Materials methods: In this prospective study serial horizontal vestibulo-ocular reflex (HVOR) gain measurements were recorded using adult inpatients receiving intravenous gentamicin. The primary outcome was proportion developing impairment their HVOR gain.Results: After exclusions, 42 included in analysis....
Acute bilateral ptosis can be a hallmark of several serious neurological conditions. We present the first case acute near-complete secondary to neuromyelitis optica spectrum disorder. suggest that clinicians should consider this disorder among differential diagnosis ptosis, especially if there are other brainstem signs.
Abstract Introduction Structural variants (SVs) of the nebulin gene ( NEB ), including intragenic duplications, deletions, and copy number variation triplicate region, are an established cause recessively inherited nemaline myopathies related neuromuscular disorders. Large deletions have been shown to dominantly distal myopathies. Here we provide overview 35 families with muscle disorders caused by such SVs in . Methods Using custom Comparative Genomic Hybridization arrays, exome sequencing,...
Abstract Chronic graft‐versus‐host disease (cGVHD) complicating allogeneic haemopoietic stem cell transplantation rarely involves the nervous system; oromandibular parafunction has not been previously reported. We describe five patients with cGVHD, presenting bruxism, limitation of mouth opening, jaw locking, pain and masseter hypertrophy. Pathophysiological mechanisms are discussed. Targeted botulinum toxin injections were an effective treatment minimal side‐effects.
ABSTRACT Objective Because clozapine and risperidone have been shown to reduce neuroinflammation in humans mice, the CRISP trial was conducted determine whether are suitable for progressive multiple sclerosis (pMS). Methods The (ACTRN12616000178448) a blinded, randomized, placebo-controlled with three parallel arms (n=12/arm). Participants pMS were randomized (100 150 mg/day), (2 3.5 or placebo six months. primary outcome measures safety (adverse events/serious adverse events) acceptability...
<h3>Objectives</h3> To investigate peripheral nerve ultrasound findings in patients with Friedreich’s ataxia (FRDA) and their relationship to the complex neuropathology of somatosensory system this condition. <h3>Methods</h3> The cross-sectional area median ulnar nerves at mid-forearm mid-humerus level eight non-diabetic FRDA (confirmed by GAA triplet expansion frataxin gene) were compared age- gender-matched healthy controls a reference population. All had sensory neuropathy reduced or...
To determine the incidence of gentamicin vestibulotoxicity (GVT) with modern dosing regimens, and to test feasibility routine video head-impulse testing on all patients given gentamicin.
<h3>Objectives</h3> We aimed to assess the diagnostic utility of a muscle biopsy in general neurology setting, and identify strategies improve patient selection. <h3>Methods</h3> The clinical records histology reports adult patients who underwent at Wellington Hospital, New Zealand, between February 2004 December 2020, were retrospectively examined. Their clinical, laboratory, electromyography findings, results, pre- post-biopsy diagnoses recorded. Based on for optimising selection have been...