A5067708911- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Caveolin-1 and cellular processes
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Lipid metabolism and disorders
- Systemic Lupus Erythematosus Research
- Blood properties and coagulation
- Retinopathy of Prematurity Studies
- Cerebral Venous Sinus Thrombosis
- Traumatic Ocular and Foreign Body Injuries
- Retinal and Macular Surgery
- Traumatic Brain Injury Research
- Cytomegalovirus and herpesvirus research
- Vascular Malformations Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Ocular Diseases and Behçet’s Syndrome
- Drug-Induced Ocular Toxicity
- Pediatric Urology and Nephrology Studies
- Photoreceptor and optogenetics research
- Cell Adhesion Molecules Research
- Infant Development and Preterm Care
- CRISPR and Genetic Engineering
- Pancreatitis Pathology and Treatment
- Kidney Stones and Urolithiasis Treatments
University of Iowa
2021-2025
University of Iowa Hospitals and Clinics
2021-2024
Hope College
2023
Oregon Health & Science University
2019
Stem Cell Institute
2017
University of Oklahoma Health Sciences Center
2013-2016
Dean McGee Eye Institute
2014-2016
Oklahoma City University
2013
University of Oklahoma
2013
Abstract Polymorphisms in the CAV1/2 genes that encode signature proteins of caveolae are associated with glaucoma, second leading cause blindness worldwide, and its major risk factor, intraocular pressure (IOP). We hypothesized caveolin-1 (Cav-1) participates IOP maintenance via modulation aqueous humor drainage from eye. localize to human murine conventional tissues show respond mechanical stimulation. Cav-1-deficient (Cav-1 −/− ) mice display ocular hypertension explained by reduced...
Adeno-associated virus (AAV)-mediated gene therapy has great potential for treating a wide range of retinal degenerative diseases. However, some initial enthusiasm been tempered by emerging evidence AAV-associated inflammation, which in several instances contributed to clinical trial discontinuation. Currently, there is paucity data describing the variable immune responses different AAV serotypes, and similarly, little known regarding how these differ depending on route ocular delivery,...
PurposeTo investigate the distribution of genotypes and natural history ABCA4-associated retinal disease in a large cohort patients seen at single institution.DesignRetrospective, single-institution review.ParticipantsPatients University Iowa between November 1986 August 2022 clinically suspected to have caused by sequence variations ABCA4.MethodsDNA samples from participants were subjected tiered testing strategy progressing allele-specific screening whole genome sequencing. Charts...
What pathways specify retinal ganglion cell (RGC) fate in the developing retina? Here we report on mechanisms by which a molecular pathway involving Sox4/Sox11 is required for RGC differentiation and optic nerve formation mice vivo, sufficient to differentiate human induced pluripotent stem cells into electrophysiologically active RGCs. These data place Sox4 downstream of RE1 silencing transcription factor regulating fate, further describe newly identified, Sox4-regulated site...
Purpose.: Caveolin-1 (Cav-1), the signature protein of caveolae, modulates inflammatory responses, and innate immunity. However, Cav-1′s role in retinal inflammation has not been rigorously tested. In this study, we examined effect Cav-1 ablation on sensitivity retina to inflammation. Methods.: knockout (KO) mice were challenged by intravitreal injection lipopolysaccharide (LPS) cell recruitment was assessed flow cytometry immunohistochemistry. Leukostasis flatmounts after perfusion with...
To report a previously undescribed case of late-onset vision loss due to retinal oxalosis in patient with primary hyperoxaluria type 2 (PH2).
Purpose: Despite numerous recent advances in retinal gene therapy using adeno-associated viruses (AAVs) as delivery vectors, there remains a crucial need to identify viral vectors with the ability transduce specific cell types and that have larger carrying capacity than AAV. In this study, we evaluate tropism of 2 chimeric helper-dependent adenoviruses (HDAds), adenovirus serotype 5 (HDAd5)/3 HDAd5/35, both ex vivo human explants rats. Methods: We transduced cultured HDAd5/3 HDAd5/35 an eGFP...
Purpose Autoimmune retinopathy (AIR) is a poorly characterized disease with wide phenotypic spectrum, complicating investigations of its underlying pathophysiology. We sought to analyze optical coherence tomography (OCT) retinal thickness changes in AIR patients.Methods A retrospective chart review from 2007 2017 was performed evaluating patients at single academic, tertiary referral center. OCT sublayer analysis performed, and paradoxical thickening phenotypes were reviewed.Results...
To describe the clinical findings of two patients with reversible ocular hypertension secondary to endogenous hypercortisolism.Retrospective, observational case series.A 65-year-old man (patient 1) and a 21-year-old woman 2) were both found have Cushing's syndrome after presentation our clinic elevated intraocular pressures (IOP).Clinical histories, ophthalmic examinations including IOP measurements, optical coherence tomography retinal nerve fiber layer, visual field testing, magnetic...
Purpose: Autoimmune retinopathy (AIR) is a poorly understood condition with wide phenotypic spectrum and heterogeneous findings on clinical examination imaging. In this study, the authors characterize features of recently described subtype AIR distinct split outer plexiform layer appearance OCT. Methods: This was retrospective, observational study patients diagnosis seen at University Iowa between January 2007 September 2023 who were found to have decreased visual acuity, central scotoma...
Purpose: To investigate the effect of macula-involving rhegmatogenous retinal detachment (RRD) repair on drusen regression. Methods: A retrospective review was performed patients with who underwent RRD repair. Longitudinal optical coherence tomography scans were reviewed by three graders, and each case grouped into one categories: regression, persistence, or mixed. Results: 14 eyes that identified. Surgical consisted pars plana vitrectomy (PPV) in 7 eyes, combined PPV scleral buckle 6...
This study aimed to clarify the value of using different types validity measures in pediatric neuropsychological evaluations. We examined relationship between performance (PVT) and symptom (SVT) tests as well demographic variables results from a screening test learning memory (i.e. Child Adolescent Memory Profile [ChAMP]) mixed sample (n = 103). There was minimal overlap PVT SVT failures. Regression analyses demonstrated that results, parental education, history special education were...