A5018280098- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- CAR-T cell therapy research
- Cancer Research and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- RNA Interference and Gene Delivery
- Animal Virus Infections Studies
- MicroRNA in disease regulation
Leiden University Medical Center
2020-2023
Utrecht University
2017
The use of human adenoviruses (hAds) as oncolytic agents has demonstrated considerable potential. However, their efficacy in clinical studies is generally moderate and often varies between patients. This may, part, be attributable to variable pre-existing neutralizing immunity patients, which can impact the antitumor lead response heterogeneity. Our aim was isolate new Ads for development vectors with low prevalence population. To this end, we isolated a collection nonhuman primate (nhp)...
Abstract Treatment of castration-resistant prostate cancer remains a challenging clinical problem. Despite the promising effects immunotherapy in other solid cancers, has remained largely unresponsive. Oncolytic viruses represent therapeutic avenue, as oncolytic virus treatment combines tumour cell lysis with activation immune system and mounting effective anti-tumour responses. Mammalian Orthoreoviruses are non-pathogenic human preference lytic replication cells. In this study, we evaluated...
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy which shows unparalleled therapeutic resistance due to its genetic and cellular heterogeneity, dense stromal tissue, immune-suppressive tumour microenvironment. Oncolytic virotherapy has emerged as new treatment modality uses tumour-specific viruses eliminate cancerous cells. Non-human primate adenoviruses of the human adenovirus B (HAdV-B) species have demonstrated considerable lytic potential in cancer cells well...
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy which shows unparalleled therapeutic resistance. Oncolytic viruses have emerged as new treatment approach and convey their antitumor activity through lysis of cancer cells. The efficacy oncolytic largely dependent on the induction immunogenic cell death (ICD) subsequent immune responses. However, concurrent generation antiviral responses may also limit virus’ window. GoraVir adenovirus derived from Human Adenovirus B...
The adenoviruses (AdVs) isolated from humans are taxonomically grouped in seven different species the Mastadenovirus genus (HAdV-A through G). AdVs apes often included one of human AdV species. Here we describe sequence analyses ten new that related to HAdV-C and were healthy western lowland gorillas, bonobos, chimpanzees, orangutans kept Dutch zoos. We analyzed these viruses compared their genome sequences those human- ape-derived NCBI GenBank database. Our data demonstrated clustering...