A5017538023- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Graphite, nuclear technology, radiation studies
- Nuclear and radioactivity studies
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Neurological Complications and Syndromes
- Cardiac Ischemia and Reperfusion
- COVID-19 Impact on Reproduction
- Immune Cell Function and Interaction
- Health, Environment, Cognitive Aging
- Bone and Joint Diseases
- Biomedical and Engineering Education
- Acute Kidney Injury Research
- Nuclear Materials and Properties
- Computational Drug Discovery Methods
- Muon and positron interactions and applications
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Preterm Birth and Chorioamnionitis
- Ectopic Pregnancy Diagnosis and Management
- Endoplasmic Reticulum Stress and Disease
- Radioactive contamination and transfer
- Reproductive Physiology in Livestock
- Alzheimer's disease research and treatments
- Pregnancy and Medication Impact
Celdara Medical (United States)
2018-2022
Brigham and Women's Hospital
2018
Beth Israel Deaconess Medical Center
2018
Harvard University
2009-2015
Harvard Stem Cell Institute
2011-2012
Several important events occur at the maternal-fetal interface, including generation of tolerance, remodeling uterine smooth muscle and its spiral arteries glands, placental construction. Fetal-derived extravillous trophoblasts come in direct contact with maternal decidual leukocytes. Macrophages represent ∼20% leukocytes this interface. In study, two distinct subsets CD14(+) macrophages (dMs) are found to be present first-trimester tissue, CD11c(HI) CD11c(LO). Gene expression analysis by...
Human decidual CD14(+) macrophages and CD56(+) NK cells were isolated from material obtained after first-trimester pregnancy terminations. Each cell type expressed a specific surface receptor for histocompatibility leukocyte antigen (HLA)-G (an MHC class Ib protein that is on extravillous trophoblasts), LILRB1 KIR2DL4 cells. Cross-linking with anti-LILRB1 or anti-KIR2DL4 resulted in up-regulation of small subset mRNAs including those IL-6, IL-8, TNFalpha detected using microarray...
Human cytomegalovirus (HCMV) encodes an endoplasmic reticulum (ER)-resident transmembrane glycoprotein, US10, expressed early in the replicative cycle of HCMV as part same cluster that known immunoevasins US2, US3, US6, and US11. We show US10 down-regulates cell surface expression HLA-G, but not classical class I MHC molecules. The unique short cytoplasmic tail HLA-G (RKKSSD) is essential its role a substrate, tri-leucine motif responsible for down-regulation HLA-G. Both kinetics degradation...
Inflammatory responses associated with ischemia/reperfusion injury (IRI) play a central role in alloimmunity and transplant outcomes. A key event driving these inflammatory is the burst of reactive oxygen species (ROS), hydrogen peroxide (H2 O2 ) as most abundant form that occurs result surgical implantation donor organ. Here, we used syngeneic rat renal IRI model to evaluate therapeutic properties APP-103, polyoxalate-based copolymer molecule containing vanillyl alcohol (VA) exhibits high...
Abstract Type 2 diabetes mellitus (T2D) is a major public health concern and characterized by sustained hyperglycemia due to insulin resistance destruction of insulin‐producing β cells. One pathological hallmark T2D the toxic accumulation human islet amyloid polypeptide (hIAPP) aggregates. Monomeric hIAPP hormone normally co‐secreted with insulin. However, increased levels in prediabetic diabetic patients can lead formation protofibrils, which are Current therapies fail address aggregation...
Problem CD 11c HI human decidual macrophages express several isoforms of 1 molecules. Their expression pattern and function required investigation. Method Study were isolated from decidua. Expression their ability to present lipid antigens T cells was studied. Results 1a, 1c, 1d all expressed on dM ϕ, a differing those previously observed. Exposure peripheral monocytes dendritic isolates decidua led increased surface 1a levels only. The 1c ϕ able the appropriate antigen‐specific cells....
Purpose Ischemia-reperfusion injury (IRI) is the strongest non-HLA factor that augments allogenicity of transplanted organs. Damage subsequent to IRI critically linked an abundance reactive oxygen species (ROS), including H202 initiates inflammation and significantly contributes allograft loss. Antioxidant Polymer Prodrugs, or APPs™, are potent, site-specific, self-limiting therapeutics mitigate by reducing localized oxidative stress. APPs innovative, highly effective, safe antioxidative...
Abstract The human maternal-fetal interface is a unique environment by which there necessary establishment of maternal tolerance to fetal antigens as well uterine spiral artery remodeling and placental growth. Decidual macrophages (dMΦs) comprise approximately 20% all leukocytes at this interface. Previously we identified two distinct populations based upon CD11c have been termed, CD11cHI CD11cLO MΦs (J Immunol. 2011; 186(4)). Based microarray analysis, dMΦs were shown significantly...
You have accessJournal of UrologyTransplantation & Vascular Surgery: Renal Transplantation Surgery I1 Apr 2018PD25-08 THE POLYMER PRO-DRUG APP-103 MITIGATES I/R INJURY AND IMPROVES GRAFT FUNCTION IN A PRE-CLINICAL RENAL TRANSPLANT MODEL Koichiro Minami, Abdallah Elkhal, Soochan Bae, Jake Reder, Brandy Houser, Peter M Kang, and Stefan G Tullius MinamiKoichiro Minami More articles by this author , ElkhalAbdallah Elkhal BaeSoochan Bae RederJake Reder HouserBrandy Houser KangPeter Kang...
The radioactive phase of the demonstration disposal high-level wastes in a salt mine was completed by end June 1967. remainder experiments were terminated, and Carey Salt Company's Lyons, Kansas, placed on standby basis, beginning February 1968. During 19-month operation demonstration, average dose to over length container holes about 8 × 108 rads, peak 109 rads. A study economics disposal-in-salt completed. calculated cost per kilowatt-hour electricity generated ranged from 20 10−3 2 mill...
Purpose: Our data introduce APP-103 as a novel, non-toxic and site-activating therapeutic approach that effectively ameliorates the consequences of ischemia/reperfusion injury in solid organ transplantation. Methods: A key event driving inflammatory responses to (IRI) is burst reactive oxygen species. exhibits high sensitivity specificity towards local production H2O2. We used an IRI syngeneic transplant model evaluate antioxidant anti-inflammatory properties downstream effects on...
Type 2 Diabetes In article number 2202342, Ronald J. Parchem and co-workers describe two hIAPP protofibril-specific antibodies which prevent β cell toxicity in type diabetes (T2D). Treatment with mAbs increases survival a mouse model of severe T2D, pancreatic islets from treated mice show decreased death macrophage infiltration, comparable to healthy wild-type animals, as depicted the photo.