A5037565562- Neurogenesis and neuroplasticity mechanisms
- Advanced Neuroimaging Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced MRI Techniques and Applications
- Multiple Sclerosis Research Studies
- Neurological Disease Mechanisms and Treatments
- Advanced NMR Techniques and Applications
- Anesthesia and Neurotoxicity Research
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- MicroRNA in disease regulation
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurological Disorders and Treatments
- Medical Imaging Techniques and Applications
- RNA regulation and disease
- Spaceflight effects on biology
- Axon Guidance and Neuronal Signaling
- Traumatic Brain Injury and Neurovascular Disturbances
- EEG and Brain-Computer Interfaces
- Atomic and Subatomic Physics Research
- Cognitive and developmental aspects of mathematical skills
- RNA Research and Splicing
- Telomeres, Telomerase, and Senescence
- Cognitive Science and Mapping
- Scientific Research and Philosophical Inquiry
National Research Tomsk State University
2015-2024
Russian State Library
2019
University of Washington
2016
Cuprizone-induced demyelination in mice is a frequently used model preclinical multiple sclerosis research. A recent quantitative clinically-targeted MRI method, fast macromolecular proton fraction (MPF) mapping demonstrated promise as myelin biomarker human and animal studies with particular advantage of sensitivity to both white matter (WM) gray (GM) demyelination. This study aimed histologically validate the capability MPF quantify loss brain tissues using cuprizone model. Whole-brain...
A selective serotonin reuptake inhibitor, fluoxetine, has recently attracted a significant interest as neuroprotective therapeutic agent. There is substantial evidence of improved neurogenesis under fluoxetine treatment brain ischemia in animal stroke models. We studied long-term effects on hippocampal neurogenesis, neuronal loss, inflammation, and functional recovery new model global cerebral (GCI). Brain was induced adult Wistar male rats by transient occlusion three main vessels...
Macromolecular proton fraction (MPF) has been established as a quantitative clinically-targeted MRI myelin biomarker based on recent demyelination studies. This study aimed to assess the capability of MPF quantify remyelination using murine cuprizone-induced reversible model. was measured in vivo fast single-point method three animal groups (control, demyelination, and after cuprizone withdrawal) compared immunohistochemistry for basic protein (MBP), myelinating oligodendrocytes...
A recent MRI method, fast macromolecular proton fraction (MPF) mapping, was used to quantify demyelination in the transient middle cerebral artery occlusion (MCAO) rat stroke model. MPF and other quantitative parameters (T 1 , T 2 density, apparent diffusion coefficient) were compared with histological immunohistochemical markers of (Luxol Fast Blue stain, (LFB)), neuronal loss (NeuN immunofluorescence), axonal (Bielschowsky stain), inflammation (Iba1 immunofluorescence) three animal groups...
Abstract Myelin deficiency is commonly recognized as an important pathological feature of brain tissues in schizophrenia (SZ). In this pilot study, global myelin content abnormalities white matter (WM) and gray (GM) SZ patients were non-invasively investigated using a novel clinically-targeted quantitative imaging technique, fast macromolecular proton fraction (MPF) mapping. MPF maps obtained from 23 healthy subjects 31 clinical 1.5T magnetic resonance (MRI) scanner. Mean WM GM was compared...
Background Single‐point macromolecular proton fraction (MPF) mapping is a recent quantitative MRI method for fast assessment of brain myelination. Information about reproducibility and sensitivity MPF to magnetic field nonuniformity important clinical applications. Purpose To assess scan–rescan repeatability value B 0 1 inhomogeneity corrections in single‐point synthetic‐reference mapping. Study Type Prospective. Population Eight healthy adult volunteers underwent two scans with 11.5 ± 2.3...
Remyelination is a key process enabling post-stroke brain tissue recovery and plasticity. This study aimed to explore the feasibility of demyelination remyelination monitoring in experimental stroke from acute chronic stage using an emerging myelin imaging biomarker, macromolecular proton fraction (MPF). After induction by transient middle cerebral artery occlusion, rats underwent repeated MRI examinations during 85 days after surgery with histological endpoints for animal subgroups on 7th,...
Background: Depression and cognitive impairment are recognized complications of COVID-19. This study aimed to assess performance in clinically diagnosed post-COVID depression (PCD, n = 25) patients using neuropsychological testing. Methods: The involved 71 with matched control groups: recovered COVID-19 individuals without (n 18) prior history 19). A group was identified based on psychiatric diagnosis, a comparison (noPCD, 46) included participants neurological complications, excluding...
Recent studies showed hepatoprotective, neuroprotective, and immunomodulatory properties of polyprenols isolated from the green verdure Picea abies (L.) Karst. This study aimed to investigate effects on oligodendrogenesis, neurogenesis, myelin content in cuprizone demyelination model. Demyelination was induced by 0.5% CD-1 mice during 10 weeks. Nine cuprizone-treated animals received daily injections intraperitoneally at a dose 12-mg/kg body weight Weeks 6-10. control other nine sham oil...
(1) Background: Although myelin disruption is an integral part of ischemic brain injury, it rarely the subject research, particularly in animal models. This study assessed for first time, and oligodendrocyte loss a three-vessel model global cerebral ischemia (GCI), which causes hippocampal damage. In addition, we investigated relationships between demyelination changes microglia astrocytes, as well oligodendrogenesis hippocampus; (2) Methods: Adult male Wistar rats (n = 15) underwent...
Astrocytes are the most abundant cell class in CNS. Astrocytic therapies have a huge potential for neuronal repair after stroke. The majority of brain stroke studies address damage to neurons. Modern turn usage morphological and functional changes astroglial cells regenerative medicine. Our study is focused on number astrocytes hippocampus (where new glia divide) ischemia. Ischemia was modeled by occlusion tr. brachiocephalicus, a. subclavia sin., carotis communis sin. were determined using...
Age-related myelination decrease is considered one of the likely mechanisms cognitive decline. The present preliminary study based on longitudinal assessment global and regional normal adult human brain using fast macromolecular fraction (MPF) mapping. Additional markers were age-related changes in white matter (WM) hyperintensities FLAIR-MRI levels anti-myelin autoantibodies serum. Eleven healthy subjects (33–60 years first study) scanned twice, seven apart. An MPF was found WM, grey (GM),...
Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Twitter Facebook Reddit LinkedIn Tools Reprints and Permissions Cite Search Site Citation M. Yu. Khodanovich, A. Kisel; Animal models of cerebral ischemia. AIP Conf. Proc. 17 November 2015; 1688 (1): 030037. https://doi.org/10.1063/1.4936032 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Dropdown Menu input auto suggest...
Background: Depression is one of the most severe sequelae COVID-19, with major depressive disorder often characterized by disruption in white matter (WM) connectivity stemming from changes brain myelination. This study aimed to quantitatively assess myelination clinically diagnosed post-COVID depression (PCD) using recently proposed MRI method, macromolecular proton fraction (MPF) mapping. Methods: The involved 63 recovered COVID-19 patients (52 mild, 11 moderate, and 2 severe) at 13.5 ±...
Age-related myelination decrease is considered one of the likely mechanisms cognitive decline. The present study based on longitudinal assessment global and regional normal adult human brain using fast macromolecular fraction (MPF) mapping. Additional markers were age-related changes in white matter (WM) hyperintensities FLAIR-MRI levels anti-myelin autoantibodies serum. Eleven healthy subjects (33–60 years first study) scanned twice, 7 apart. An MPF was found WM, GM, mixed WM-GM, as well 48...
Depression is one of the most severe sequelae COVID-19, with major depressive disorder often characterized by disruption in white matter (WM) connectivity , stemming from changes brain myelination. This study aimed to quantitatively assess myelination clinically diagnosed post-COVID depression using recently proposed MRI method, macromolecular proton fraction (MPF) mapping. The involved 63 recovered COVID-19 patients (52 mild, 11 moderate, 2 severe) at 13.5±10.0 months post-recovery, matched...
Traditionally histology is the gold standard for validation of imaging experiments. Matching slices and histological sections precise outlining corresponding tissue structures are difficult. Challenges based on differences in slice thickness as well shrinkage alterations after processing. Here we describe step-by-step instructions that might be used a universal pathway to overlay MRI images correlation measurements between modalities. The free available (Fiji just) ImageJ software tools were...
(1) Background: Neurogenesis is considered to be a potential brain repair mechanism and enhanced in stroke. It difficult reconstruct the neurogenesis process only from histological sections taken different animals at stages of damage restoration. Study would greatly benefit development tissue-specific visualization probes. (2) Purpose: The study aimed explore if overexpression ferritin, nontoxic iron-binding protein, under doublecortin promoter can used for non-invasive using magnetic...