A5038243706- Advanced Neuroimaging Techniques and Applications
- Vestibular and auditory disorders
- Action Observation and Synchronization
- Epilepsy research and treatment
- Human Health and Disease
- Technology and Human Factors in Education and Health
- Neural dynamics and brain function
- Long-Term Effects of COVID-19
- Neurogenesis and neuroplasticity mechanisms
- COVID-19 and Mental Health
- Fusion and Plasma Physics Studies
- Stress Responses and Cortisol
- Biochemical effects in animals
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Spaceflight effects on biology
- Pharmacological Effects and Toxicity Studies
- Diet and metabolism studies
- Humic Substances and Bio-Organic Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Heart Rate Variability and Autonomic Control
- Cognitive Science and Mapping
- Neurological Disorders and Treatments
- Adipose Tissue and Metabolism
- Sleep and Wakefulness Research
National Research Tomsk State University
2010-2024
Siberian State Medical University
2010-2024
Ministry of Health of the Russian Federation
2020
Institute of Animal Physiology of the Slovak Academy of Sciences
2019
Macromolecular proton fraction (MPF) has been established as a quantitative clinically-targeted MRI myelin biomarker based on recent demyelination studies. This study aimed to assess the capability of MPF quantify remyelination using murine cuprizone-induced reversible model. was measured in vivo fast single-point method three animal groups (control, demyelination, and after cuprizone withdrawal) compared immunohistochemistry for basic protein (MBP), myelinating oligodendrocytes...
A recent MRI method, fast macromolecular proton fraction (MPF) mapping, was used to quantify demyelination in the transient middle cerebral artery occlusion (MCAO) rat stroke model. MPF and other quantitative parameters (T 1 , T 2 density, apparent diffusion coefficient) were compared with histological immunohistochemical markers of (Luxol Fast Blue stain, (LFB)), neuronal loss (NeuN immunofluorescence), axonal (Bielschowsky stain), inflammation (Iba1 immunofluorescence) three animal groups...
Background: Depression and cognitive impairment are recognized complications of COVID-19. This study aimed to assess performance in clinically diagnosed post-COVID depression (PCD, n = 25) patients using neuropsychological testing. Methods: The involved 71 with matched control groups: recovered COVID-19 individuals without (n 18) prior history 19). A group was identified based on psychiatric diagnosis, a comparison (noPCD, 46) included participants neurological complications, excluding...
Age-related myelination decrease is considered one of the likely mechanisms cognitive decline. The present preliminary study based on longitudinal assessment global and regional normal adult human brain using fast macromolecular fraction (MPF) mapping. Additional markers were age-related changes in white matter (WM) hyperintensities FLAIR-MRI levels anti-myelin autoantibodies serum. Eleven healthy subjects (33–60 years first study) scanned twice, seven apart. An MPF was found WM, grey (GM),...
It is known that desynchronosis and physical stress to the point of fatigue are powerful stressors for body. Studies indicate a depleting effect combined factors on adaptive reserves organism, especially when joint exposure prolonged. However, value training process in various activities also well known. In this regard, it seems important study these two aspects adaptation effects light overwork Р urpose was features reactions rats under conditions overwork. Materials methods . An...
Background: Depression is one of the most severe sequelae COVID-19, with major depressive disorder often characterized by disruption in white matter (WM) connectivity stemming from changes brain myelination. This study aimed to quantitatively assess myelination clinically diagnosed post-COVID depression (PCD) using recently proposed MRI method, macromolecular proton fraction (MPF) mapping. Methods: The involved 63 recovered COVID-19 patients (52 mild, 11 moderate, and 2 severe) at 13.5 ±...
Age-related myelination decrease is considered one of the likely mechanisms cognitive decline. The present study based on longitudinal assessment global and regional normal adult human brain using fast macromolecular fraction (MPF) mapping. Additional markers were age-related changes in white matter (WM) hyperintensities FLAIR-MRI levels anti-myelin autoantibodies serum. Eleven healthy subjects (33–60 years first study) scanned twice, 7 apart. An MPF was found WM, GM, mixed WM-GM, as well 48...
Depression is one of the most severe sequelae COVID-19, with major depressive disorder often characterized by disruption in white matter (WM) connectivity , stemming from changes brain myelination. This study aimed to quantitatively assess myelination clinically diagnosed post-COVID depression using recently proposed MRI method, macromolecular proton fraction (MPF) mapping. The involved 63 recovered COVID-19 patients (52 mild, 11 moderate, 2 severe) at 13.5±10.0 months post-recovery, matched...
To study an effect of mexidol on the performance rats after light or dark deprivations in swimming test with a load and to evaluate state glycolytic processes under these conditions.The experiment was carried out spring 70 Wistar male rats. Three groups (30 animals) were natural conditions. One them not affected. The other two subjected exercise 30 minutes before it either saline administered intramuscularly. Four (40 for 10 days conditions deprivation prior presentation physical activity...
Traditionally histology is the gold standard for validation of imaging experiments. Matching slices and histological sections precise outlining corresponding tissue structures are difficult. Challenges based on differences in slice thickness as well shrinkage alterations after processing. Here we describe step-by-step instructions that might be used a universal pathway to overlay MRI images correlation measurements between modalities. The free available (Fiji just) ImageJ software tools were...
(1) Background: Neurogenesis is considered to be a potential brain repair mechanism and enhanced in stroke. It difficult reconstruct the neurogenesis process only from histological sections taken different animals at stages of damage restoration. Study would greatly benefit development tissue-specific visualization probes. (2) Purpose: The study aimed explore if overexpression ferritin, nontoxic iron-binding protein, under doublecortin promoter can used for non-invasive using magnetic...
OBJECTIVE To study of efficacy and safety mexidol used as intravenous infusion for 14 days, followed by per os treatment with FORTE 250 60 days in patients chronic brain ischemia (CHM) complicated arterial hypertension atherosclerosis. MATERIAL AND METHODS The group included 27 (24 women 3 men) CHM I-II gr the combination atherosclerosis who received infusions (500 mg once daily) within subsequent a daily dose 750 (1 tablet times day) days. comparison consisted 30 (22 8 gr, comparable age,...
We investigated the predictors of increased seizures’ frequency among women with various forms idiopathic generalized epilepsies (IGE) in gestational and postgravid period. observed 41 patients Idiopathic epilepsy before, during after pregnancy. During period observation EEG was recorded states relaxed active awakeness sleeping. Patients, who have stopped to take anticonvulsants before pregnancy, had seizures, more than1 ina year, interictal epileptiform discharges a state awakeness....
Objective. Several lumped and distributed parameter models of the inner ear have been proposed to improve vestibular implant stimulation. The should account for all significant physical phenomena that influence current propagation, such as electrical double layer (EDL) medium polarization. properties are reflected in impedance; therefore, study aimed measure impedance guinea pig construct its equivalent circuit.Approach. was measured from 100 Hz 50 kHz between a pair platinum electrodes...
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Depression and cognitive impairment are recognized complications of COVID-19. This study aimed to assess performance in clinically diagnosed post-COVID depression (PCD) patients using neuropsychological testing. The involved 71 patients, with matched control groups: recovered COVID-19 individuals without (n=18) prior history (n=19). A group (PCD, n=25) was identified based on psychiatric diagnosis, a comparison (noPCD, n=46) included participants neurological complications, excluding...
The development and widespread practical application of in vitro embryo production technology will make it possible to replenish the herd population a short time, preserve replicate valuable genotypes, as well create new genotypes using method genome editing. Livestock breeding is tasked with providing agriculture high–value fairly while farmers are charged replenishing which only active introduction assisted reproductive technologies, such (IVP technology). use domestically produced...
Bilateral asymmetry in the function of semicircular canals underlies dizziness and vestibular balance disorders. According to traditional view, otolith dysfunction does not have a significant effect on clinical picture individuals with peripheral In recent years, interest studying contribution control posture movements has increased. However, we identified any studies addressing reactivity organs disorders available literature. Aim: To study bilateral reactions patients using method cervical...