A5063245569- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Metabolomics and Mass Spectrometry Studies
- Advanced Neuroimaging Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Medical Image Segmentation Techniques
- Olfactory and Sensory Function Studies
- Stress Responses and Cortisol
- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- Lanthanide and Transition Metal Complexes
- Receptor Mechanisms and Signaling
- Mitochondrial Function and Pathology
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Liver Disease Diagnosis and Treatment
- Neuroendocrine regulation and behavior
- Cardiovascular Function and Risk Factors
- Pancreatic function and diabetes
- Food Quality and Safety Studies
- Nanoparticle-Based Drug Delivery
- Advanced Chemical Sensor Technologies
- Medicinal Plants and Bioactive Compounds
- Nanoplatforms for cancer theranostics
Institute of Cytology and Genetics
2015-2024
International Tomography Center
2015-2024
Lavrentyev Institute of Hydrodynamics
2024
Siberian Branch of the Russian Academy of Sciences
2013-2021
Novosibirsk State University
2018-2021
University of Southern California
2019
National Research Tomsk State University
2016-2018
Google (United States)
2015
Russian Academy of Sciences
2011-2014
Cuprizone-induced demyelination in mice is a frequently used model preclinical multiple sclerosis research. A recent quantitative clinically-targeted MRI method, fast macromolecular proton fraction (MPF) mapping demonstrated promise as myelin biomarker human and animal studies with particular advantage of sensitivity to both white matter (WM) gray (GM) demyelination. This study aimed histologically validate the capability MPF quantify loss brain tissues using cuprizone model. Whole-brain...
Cellular and organismal aging are driven in part by the MTOR (mechanistic target of rapamycin) pathway rapamycin extends life span C elegans, Drosophila mice. Herein, we investigated effects on brain OXYS rats. Previously found, rats, an early development age-associated pathological phenotypes similar to several geriatric disorders humans, including cerebral dysfunctions. Behavioral alterations as well learning memory deficits develop 3 months. Here show that treatment (0.1 or 0.5 mg/kg a...
Macromolecular proton fraction (MPF) has been established as a quantitative clinically-targeted MRI myelin biomarker based on recent demyelination studies. This study aimed to assess the capability of MPF quantify remyelination using murine cuprizone-induced reversible model. was measured in vivo fast single-point method three animal groups (control, demyelination, and after cuprizone withdrawal) compared immunohistochemistry for basic protein (MBP), myelinating oligodendrocytes...
A recent MRI method, fast macromolecular proton fraction (MPF) mapping, was used to quantify demyelination in the transient middle cerebral artery occlusion (MCAO) rat stroke model. MPF and other quantitative parameters (T 1 , T 2 density, apparent diffusion coefficient) were compared with histological immunohistochemical markers of (Luxol Fast Blue stain, (LFB)), neuronal loss (NeuN immunofluorescence), axonal (Bielschowsky stain), inflammation (Iba1 immunofluorescence) three animal groups...
In vivo proton magnetic resonance spectroscopy ( 1 H MRS) of outbred stock ICR male mice (originating from the Institute Cancer Research) was used to study brain (hippocampus) metabolic response pro‐inflammatory stimulus and acute deficiency available energy, which confirmed by measuring maximum oxygen consumption. Inhibition glycolysis means an injection with 2‐deoxy‐ d ‐glucose (2DG) reduced levels gamma‐aminobutyric acid (GABA, p < 0.05, in comparison control, least significant...
Multifunctional gold nanoparticles (AuNPs) may serve as a scaffold to integrate diagnostic and therapeutic functions into one theranostic system, thereby simultaneously facilitating diagnosis therapy monitoring responses. Herein, albumin-AuNP agents have been obtained by conjugation of an anticancer nucleotide trifluorothymidine (TFT) or boron-neutron capture drug undecahydro-closo-dodecaborate (B12H12) bimodal human serum albumin (HSA) followed reacting the conjugates with AuNPs. In vitro...
New Findings What is the central question of this study? Stress‐sensitive arterial hypertension considered to be controlled by changes in and peripheral sympathetic regulating mechanisms, which eventually result haemodynamic alterations blood pressure elevation. Therefore, study early stages development particular interest, because it helps understanding aetiology disease. main finding its importance? Non‐invasive vivo investigation ISIAH rats demonstrated that establishment sustainable...
One important syndrome of psychiatric disorders in humans is catalepsy. Here, we created mice with different predispositions to catalepsy and analysed their pharmacological behavioural properties.Two mouse lines, B6-M76C B6-M76B, were by transfer the main locus containing 5-HT1A receptor gene C57BL/6 genetic background. Behaviour, brain morphology, expression key components serotoninergic system, responses acute chronic stimulation compared.B6-M76B not cataleptic, whereas 14% demonstrated...
(1) Recently, metabolic profiling of the tissue in native state or extracts its metabolites has become increasingly important field metabolomics. An factor, this case, is presence blood a sample, which can potentially lead to change concentration and, as result, distortion experimental data and their interpretation. (2) In paper, metabolomic based on NMR spectroscopy was performed determine effect contained studied samples brain profile. We used 13 male laboratory CD-1® IGS mice for study....
Inhalation of air-dispersed sub-micrometre and nano-sized particles presents a risk factor for animal human health. Here, we show that nasal aerodynamics plays pivotal role in the protection subterranean mole vole Ellobius talpinus from an increased exposure to nano-aerosols. Quantitative simulation particle flow has shown their deposition on total surface cavity is higher than terrestrial rodent Mus musculus (mouse), but lower olfactory epithelium. In agreement with results, found reduced...
Background The medications produced from natural products are widely used as prophylactics for sickness induced by alcohol consumption. One such prophylactic is the Reishi mushroom, Ganoderma lucidum . Because of antioxidant properties these preparations, we expect neuroprotective effects Reishi‐based in alcohol‐treated animals. Methods (R) suspension was water extract Altaian mushrooms. Sprague–Dawley male rats were separated into following 3 experimental groups: Group A + R received (6...
A paradoxical reduction in anxiety levels chronic predator stress paradigm (PS) Sprague-Dawley rats has recently been shown previous works. In this paper, we studied the possible neurobiological mechanism of phenomenon. We segregated PS-exposed into high- and low-anxiety phenotypes. The long-lasting effects PS on corticosterone levels, blood flow speed carotid arteries, diffusion coefficient, 1H nuclear magnetic resonance spectra hippocampus were compared high-anxiety rats. addition,...
Herein, we report a novel strategy to engineer an acid-sensitive anticancer theranostic agent using vector–drug ensemble. The ensemble was synthesized by directly conjugating the linoleic acid (LA)-modified branched polyethyleneimine with chemotherapeutic drug trifluorothymidine. Linoleic residues were grafted onto 25 kDa (PEI) treating PEI chloroanhydride. 5-Trifluoromethyl-2′-deoxyuridine (trifluorothymidine, TFT) introduced into LA-PEI conjugate phosphorylating amidophosphate of...
In our experiments, we investigate a flow of viscous fluid in the model common carotid artery bifurcation. The studies are carried out using three hardware equipments: two magnetic resonance scanners by Philips and Bruker, intravascular guidewire ComboWire. flux is generated special pump CompuFlow that designed to reproduce similar one blood vessels. A verification obtained data out. Conducted research shows capabilities measurement instruments reflects character inside model.