A5083137924- Estrogen and related hormone effects
- Breast Lesions and Carcinomas
- AI in cancer detection
- Digital Radiography and Breast Imaging
- Cancer Cells and Metastasis
- HER2/EGFR in Cancer Research
- Lymphoma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Cytokine Signaling Pathways and Interactions
- Retinoids in leukemia and cellular processes
- Medical Imaging Techniques and Applications
- Cancer Genomics and Diagnostics
- Global Cancer Incidence and Screening
- Cancer Research and Treatments
- MRI in cancer diagnosis
- NF-κB Signaling Pathways
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Genetic and Kidney Cyst Diseases
- Chronic Myeloid Leukemia Treatments
- Neuroendocrine Tumor Research Advances
- Genetic Syndromes and Imprinting
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Lung Cancer Diagnosis and Treatment
University of Kansas
2007-2023
University of Kansas Medical Center
2014-2021
Truman Medical Center
1988-2019
Wichita State University
2019
Stowers Institute for Medical Research
2019
St. Luke's Hospital
2017
St. Vincent's Medical Center
2017
Wichita Clinic
2017
St. Luke's Hospital
2017
University of Missouri–Kansas City
1988
Purpose To determine improvement in breast cancer detection by using supplemental three-dimensional (3D) automated (AB) ultrasonography (US) with screening mammography versus alone asymptomatic women dense breasts. Materials and Methods Institutional review board approval written informed consent were obtained for this HIPAA-compliant study. The SomoInsight Study was an observational, multicenter study conducted between 2009 2011. A total of 15 318 (mean age, 53.3 years ± 10 [standard...
The objective of our study was to assess and compare, in a reader study, radiologists' performance the detection breast cancer using full-field digital mammography (FFDM) alone FFDM with 3D automated ultrasound (ABUS).In this multireader, multicase, sequential-design 17 Mammography Quality Standards Act-qualified radiologists interpreted cancer-enriched set ABUS examinations. All imaging studies were asymptomatic women BI-RADS C or D density. Readers first subsequently combined ABUS....
Interpretation Time Using a Concurrent-Read Computer-Aided Detection System for Automated Breast Ultrasound in Cancer Screening of Women With Dense TissueYulei Jiang1, Marc F. Inciardi2, Alexandra V. Edwards1 and John Papaioannou1Audio Available | Share Claim CREDIT
There are an estimated 60,000 new cases of ductal carcinoma in situ (DCIS) each year. A lack understanding DCIS pathobiology has led to overtreatment more than half patients. We profiled the temporal molecular changes during transition invasive (IDC) using vivo progression models. These studies identified B cell lymphoma-9 (BCL9) as a potential driver early invasion. BCL9 is newly found co-activator Wnt-stimulated β-catenin-mediated transcription. been shown promote multiple myeloma and...
The objective of our study was to evaluate positioning full-field digital mammography (FFDM) and breast tomosynthesis (DBT) compared with film-screen (FS) standards.A retrospective conducted consecutive patients who underwent screening FFDM in 2010-2012 DBT 2012-2013 at an academic institution. Examinations were performed by five experienced technologists updated standardized training. Positioning criteria assessed consensus reads among three radiologists FS data from a 1993 Bassett...
Due to widespread adoption of screening mammography, there has been a significant increase in new diagnoses ductal carcinoma situ (DCIS). However, DCIS prognosis remains unclear. To address this gap, we developed an vivo model, Mouse-INtraDuctal (MIND), which patient-derived epithelial cells are injected intraductally and allowed progress naturally mice. Similar human DCIS, the cancer formed lesions inside mouse mammary ducts mimicked all histologic subtypes including micropapillary,...
Supplemental screening with ultrasound has been shown to detect additional breast malignancies in women dense tissue and normal mammogram findings. The frequency of supplemental automated the effect type density notification on utilization rates are unknown.We examined results letters for patients heterogeneously or extremely between July 1, 2013, June 30, 2014, by letter, method, sociodemographic characteristics. Logistic regression was used examine association letter subsequent...
The beneficial versus detrimental roles of estrogen plus progesterone (E+P) in breast cancer remains controversial. Here we report a mechanism E+P treatment cells driven by transcriptional upregulation the NFκB modulator NEMO, which turn promotes expression tumor suppressor protein promyelocytic leukemia (PML). patient-derived epithelial derived from ductal carcinoma
Dense breast tissue is an independent risk factor for cancer and reduces the sensitivity of mammography. Patients with dense are more likely to present interval cancers higher-stage disease. Successful screening outcomes rely on detection early-stage cancers; therefore, several supplemental modalities have been developed improve in tissue. US most widely used modality worldwide has proven demonstrate additional mammographically occult that predominantly invasive node negative. According...
Background: NCCN guidelines recommend surgical excision for patients with atypical ductal hyperplasia (ADH) on percutaneous biopsy. Improved imaging and biopsy techniques have lower contemporary upgrade rates, challenging standard practice. We sought to identify low-risk features of ADH define who may benefit from active monitoring over excision.Methods: A retrospective analysis identified 87 stereotactic biopsies diagnosing undergoing at a single institution 01/2008 10/2015. Imaging was...
Abstract Objective To determine the frequency of incidental breast findings reported on chest CT for which imaging follow-up is recommended, adherence rate, and malignancy rate. The relationship between strength recommendation verbiage was also explored. Methods A retrospective review conducted reports from July 1, 2018, to June 30, 2019, identify those with follow-up. Patients recently diagnosed or prior history were excluded. Medical records reviewed evaluate patient follow-up, subsequent...
Caroli's disease is a relatively uncommon form of hepatic cystic which, in the past, was best diagnosed conclusively by surgical exploration. The present case reported to illustrate utility technetium-labeled hepatobiliary agents establishing diagnosis.
Abstract Introduction: The ability of the ovarian steroid hormones estradiol (E) and progesterone (P) to influence cancer stem cell (CSC) self-renewal progression human ductal carcinoma in situ (DCIS) is a critical but understudied area or research. objective this study characterize hormone signaling involved CSC invasion ER+PR+ DCIS. We have found that these can increase subset DCIS patients, may be facilitated by activation IL-6 pathway. Methods: Mammosphere (MS) assays (an vitro...