A5064746788- Genomics and Phylogenetic Studies
- Genetics, Aging, and Longevity in Model Organisms
- Natural product bioactivities and synthesis
- Peroxisome Proliferator-Activated Receptors
- Soil Carbon and Nitrogen Dynamics
- Invertebrate Immune Response Mechanisms
- Plant and Fungal Species Descriptions
- Metabolomics and Mass Spectrometry Studies
- Computational Drug Discovery Methods
- Plant Molecular Biology Research
- Plant Parasitism and Resistance
- Autophagy in Disease and Therapy
- Gut microbiota and health
- Neurobiology and Insect Physiology Research
- Gene expression and cancer classification
- Plant Pathogens and Fungal Diseases
- Plant Disease Resistance and Genetics
- Mosquito-borne diseases and control
- Cynara cardunculus studies
- Genetic Mapping and Diversity in Plants and Animals
- Machine Learning in Bioinformatics
- Plant and animal studies
- Phytochemistry and Biological Activities
- Plant-Microbe Interactions and Immunity
- Advanced Battery Materials and Technologies
Hunan University of Arts and Science
2021-2025
Iowa State University
2017-2024
Harvard University
2022-2024
Innovation Team (China)
2023-2024
University of South China
2024
Central South University
2024
The First People's Hospital of Changde
2024
Boston VA Research Institute
2022-2024
Baise University
2023
Hunan Normal University
2020-2022
Our work investigates the problem of retrieving maximum item from a set in crowdsourcing environments. We first develop parameterized families max algorithms, that take as input items and output an is believed to be maximum. Such algorithms could, for instance, select best Facebook profile matches given person or photo describes restaurant. Then, we propose strategies appropriate algorithm parameters. framework supports various human error cost models consider many them our experiments....
Age-related impairment of macroautophagy/autophagy and loss cardiac tissue homeostasis contribute significantly to cardiovascular diseases later in life. MTOR (mechanistic target rapamycin kinase) signaling is the most well-known regulator autophagy, cellular homeostasis, longevity. The consists two structurally functionally distinct multiprotein complexes, MTORC1 MTORC2. While well characterized but role MTORC2 aging autophagy remains poorly understood. Here we identified TGFB-INHB/activin...
Aging is accompanied with loss of tissue homeostasis and accumulation cellular damages. As one the important metabolic centers, liver shows age-related dysregulation lipid metabolism, impaired detoxification pathway, increased inflammation oxidative stress response. However, mechanisms for these changes still remain unclear. In fruit fly, Drosophila melanogaster, liver-like functions are controlled by two distinct tissues, fat body oenocytes. Compared to body, little known about how...
Abstract Aging is characterized by a chronic, low-grade inflammation, which major risk factor for cardiovascular diseases. It remains poorly understood whether pro-inflammatory factors released from non-cardiac tissues contribute to the non-autonomous regulation of age-related cardiac dysfunction. Here, we report that age-dependent induction cytokine unpaired 3 (upd3) in Drosophila oenocytes (hepatocyte-like cells) primary mechanism aging. We show upd3 significantly up-regulated aged...
Oenocytes are large secretory cells present in the abdomen of insects known to synthesize very-long-chain fatty acids produce hydrocarbons and pheromones that mediate courtship behavior adult flies. In recent years, oenocytes have been implicated regulation energy metabolism. These hepatocyte-like accumulate lipid droplets under starvation can non-autonomously regulate tracheal waterproofing adipocyte composition. Here, we summarize evidence, mostly from Drosophila , establishing perform...
Gene mining is crucial for understanding the regulatory mechanisms underlying complex biological processes, particularly in plants responding to environmental conditions. Traditional machine learning methods, while useful, often overlook important gene relationships due their reliance on manual feature selection and limited ability capture inter-gene dynamics. Deep approaches, powerful, are unsuitable small sample sizes. This study introduces TransGeneSelector, first deep framework...
Abstract Background Artichoke ( Cynara scolymus L. ) is a typical element of traditional Mediterranean diet and has potential health advantages for insulin resistance (IR) type 2 diabetes mellitus (T2DM). This study aims to evaluate the effect underlying mechanism artichoke water extract (AWE) on palmitate (PA)-induced IR in human hepatocellular carcinoma (HepG2) cells. Methods The AWE cell viability was determined using CCK8 assay. Cellular glucose uptake, consumption, production, glycogen...
Tumors require metabolic adaptations to support their rapid growth, but how they influence lipid metabolism in distant tissues remains poorly understood. Here, we uncover a novel mechanism by which gut tumors adult flies reprogram distal hepatocyte-like cells, known as oenocytes, promote tracheal development and tumor growth. We show that secrete PDGF/VEGF-like factor, Pvf1, activates the TORC1-Hnf4 signaling pathway oenocytes. This activation enhances production of specific lipids,...
It is well known that seed vigor essential for agricultural production and rice (Oryza sativa L.) one of the most important crops in world. Though we previously reported miR164c regulates vigor, but whether how other miRNAs cooperate with to regulate still unknown.Based on degradome data six RNA samples isolated from seeds wild-type (WT) indica cultivar 'Kasalath' as two modified lines background (miR164c-silenced line [MIM164c] overexpression [OE164c]), which were subjected either no aging...
Centaurea cyanus has been a weed in farmland for long time. In this study, the chloroplast genome of C. was sequenced to establish phylogenetic relationship between its genomic characteristics and other related species. The gene structure is circular molecule with length 152,433 bp, including large single-copy (LSC) region 83,464 small (SSC) 18,545 pair inverted repeats sequences (IRs) 25,212 bp. whole contains 130 genes, 86 protein-coding 36 tRNA eight rRNA genes. Phylogenetic analysis...
Abstract Impaired organelle-specific protein import triggers a variety of cellular stress responses, including adaptive pathways to balance homeostasis. Most the previous studies focus on response triggered by misfolded proteins or defective in endoplasmic reticulum mitochondria. However, little is known about impaired peroxisome, an understudied organelle that has recently emerged as key signaling hub for and metabolic To uncover evolutionarily conserved responses upon peroxisomal import,...
Mitochondrial genomes in the Pinaceae family are notable for their large size and structural complexity. In this study, we sequenced analyzed mitochondrial genome of Cathaya argyrophylla, an endangered endemic species, uncovering a 18.99 Mb, meaning largest reported to date. To investigate mechanisms behind exceptional size, conducted comparative analyses with other species possessing both small genomes, as well gymnosperms. We focused on repeat sequences, transposable element activity, RNA...
Cathaya argyrophylla is an ancient Pinaceae species endemic to China that listed on the IUCN Red List. Although C. ectomycorrhizal plant, relationship between its rhizospheric soil microbial community and properties related natural habitat remains unknown. High-throughput sequencing of bacterial 16S rRNA genes fungal ITS region sequences was used survey at four spatially distributed points in Hunan Province, China, functional profiles were predicted using PICRUSt2 FUNGuild. The dominant...
MicroRNAs (miRNAs) play important roles in various aspects of plant physiology and metabolism. The expression level miR164c is negatively correlated with seed vigor rice (Oryza sativa L.); however, the mechanism regulation by remains unknown. Anti-aging capacity an indicator vigor. Here, we report miR164c-guided gene/protein interaction network that regulates anti-aging ability seeds. Seeds wild-type (WT) cultivar "Kasalath" its transgenic derivatives, miR164c-silenced line (MIM164c)...
Strain HUAS 3-15 T was isolated from the leaves of Cathaya argyrophylla collected Chenzhou, Hunan Province, PR China. The main fatty acids (>5.0 %) strain were anteiso -C 15 : 0 , C 16 18 1 ω9 c iso- summed feature 5 (C 2 ω6,9 /C ante), and anteiso- 17 . MK-9(H 6 ), 8 ) 4 detected as respiratory quinones. diagnostic cell-wall diamino acid meso -diaminopimelic acid. Galactose, glucose ribose also present in cell wall. major polar lipids consisted diphosphatidylglycerol, phosphatidyl...
The Diospyros genus (Ebenaceae) has significant economic value. During field surveys, we discovered a specimen showing morphological overlap with both D. oleifera and kaki var. silvestris, provisionally named aff. oleifera. To resolve its taxonomy, sequenced analyzed chloroplast genome. complete genome is 157,732 bp quadripartite structure. mVISTA analysis revealed unique sequence variations compared to related species. Phylogenetic using 75 protein-coding genes grouped it oleifera,...
Abstract Calendula officinalis L.is a versatile medicinal plant with numerous applications in various fields. However, its chloroplast genome structure, features, phylogeny, and patterns of evolution mutation remain largely unexplored. This study examines the genome, codon usage bias, divergence time C. , enhancing our understanding adaptation. The is 150,465 bp circular molecule G + C content 37.75% comprises 131 genes. Phylogenetic analysis revealed close relationship between arvensis...
Sedum bulbiferum is a traditional medicinal plant in China, with few reports on its chloroplast genome. In this study, the genome of was characterized, and phylogenetic position among other closely related species studied. The results showed that full length 150,074 bp, containing large single-copy (LSC) region small (SSC) 81,730 16,726 respectively, as well two inverted repeat regions (IRs) 25,809 bp like plants. A total 128 genes were found, including 83 protein-coding genes, 37 tRNA eight...