A5069149011- Advanced MRI Techniques and Applications
- NMR spectroscopy and applications
- Advanced Neuroimaging Techniques and Applications
- Medical Imaging Techniques and Applications
- Advanced NMR Techniques and Applications
- MRI in cancer diagnosis
- Ultrasound Imaging and Elastography
- Infrared Thermography in Medicine
- Radiomics and Machine Learning in Medical Imaging
- Advanced Mathematical Modeling in Engineering
- Non-Invasive Vital Sign Monitoring
- Photoacoustic and Ultrasonic Imaging
- Functional Brain Connectivity Studies
- Optical Imaging and Spectroscopy Techniques
Forschungszentrum Jülich
2007-2024
Jülich Aachen Research Alliance
2023
RWTH Aachen University
2011-2023
Water concentration is tightly regulated in the healthy human brain and changes only slightly with age gender subjects. Consequently, water content are important for characterization of disease. MRI can be used to measure content, but as these usually low percentage range, highly accurate precise methods required detection. The method proposed here based on a long-TR (10 s) multiple-echo gradient-echo measurement an acquisition time 7:21 min. Using such long TR ensures that there no T1...
Abstract Nuclear magnetic resonance imaging (MRI) and complementary analytical techniques were used to address the question whether white asparagus ( Asparagus officinalis L.) from different cultivation sites in Germany can be distinguished on basis of NMR relaxation times. Five locations with contrasting soil properties composition within two asparagus‐cultivation regions Rhineland Lower Franconia selected for this project. For first time, entire plants their authentic environment excavated...
Quantitative imaging of the human brain is great interest in clinical research as it enables identification a range MR biomarkers useful diagnosis, treatment and prognosis wide spectrum diseases. Here, 3D two-point method for water content relaxation time mapping presented compared to established gold standard methods. The determines free content, H2O, longitudinal time, T1, quantitatively from fit signal equation including corrections transmit receive fields. In addition, effective...
Artificial, anisotropic fibre phantoms are nowadays increasingly used in the field of diffusion-weighted MRI. Such represent useful tools for, among others, calibration pulse sequences and validation diffusion models since they can mimic well-known structural features brain tissue on one hand, but exhibit a reduced complexity, other. Among all materials, polyethylene fibres have been widely due to their excellent properties regarding restriction water surface relaxation properties. Yet...
Purpose Brain water content provides rich tissue contrast comparable to that of longitudinal relaxation time T 1 , but mapping is usually performed at modest resolution. In particular, the slice thickness in 2D methods limited. Here, we combine super‐resolution reconstruction techniques with a fast method acquire high and isotropic resolution (0.75 mm) maps 3 Tesla. Methods A high‐resolution multi‐echo gradient echo image super‐resolution–reconstructed from low‐resolution, orthogonal...
QRAGE is a novel imaging sequence and reconstruction method for the simultaneous mapping of multiple quantitative MRI parameters, including water content, T1, T2*, magnetic susceptibility at ultrahigh field strength. employs ME-MPnRAGE that acquires 171 contrast images different inversion echo time points, enabling accurate precise parameter estimation. It further incorporates model-based method, MIRAGE2, leverages prior knowledge temporal signal evolution represented as damped complex...
T2* relaxation in the brain covers a broad range of values, which can be grouped three, roughly logarithmically spaced, intervals (short, intermediate, very long). Using multi-echo GRE sequence to quantify is time-efficient for parenchyma, but accurate quantification slow-relaxing water pools, such as CSF, lengthens acquisition time. In this work, we propose novel (ES-QUTE) that combines with echo shifting techniques effectively whole times without increasing scan addition, ES-QUTE...
Quantitative brain atlases can be combined in multiparametric characterisations of the same template voxel with a number microstructure-sensitive quantities, potentially enabling earlier and more specific characterisation changes caused by disease. We combine this study two quantitative atlases, absolute water content myelin fraction, to generate novel atlas describing content. This is relevant as baseline for investigating inflammatory diseases involving both demyelination edema. The...
The development of fast, accurate, and robust methods for multiparametric quantitative MRI (qMRI) at ultrahigh field strength remains an important topic research. Here, we present a novel qMRI technique the simultaneous quantification water content, T1, T2*, magnetic susceptibility, termed QRAGE. proposed method combines highly undersampled multi-echo MPnRAGE sequence with model-based reconstruction approach. It acquires 171 different contrasts full brain coverage 1 mm isotropic resolution...
Animal models have an indisputable role in the investigation of brain pathology. Investigating water content vivo could lead to a better understanding pathogenesis and hence, robust technique measure using MRI would be very beneficial. Here, we adapt super-resolution-based technique, previously developed for humans, rat report high-resolution (200μm isotropic) maps, obtained 9.4T scanner. High resolution, isotropic maps are demonstrated. The values proposed MR compared with ex wet/dry methods.
To introduce quantitative rapid gradient-echo (QRAGE), a novel approach for the simultaneous mapping of multiple MRI parameters, including water content, T
Motivation: Quantitative MRI at clinical strengths is well-established, yet RF inhomogeneity ultrahigh-field strength, such as 7T, complicates tissue-specific measurement. Goal(s): To extend quantitative water content mapping from to MRI. Approach: We utilize a modified variable flip angle method acquire high-resolution parametric maps 7T within 7.5 minutes. Results: Method validity affirmed by comparing and relaxometry data healthy cohort against 3T benchmarks reported literature. Impact:...
Motivation: To investigate tumour-associated diffusion hyperintensitiesGoal(s): Might provide some insight into tumour environment leading to restricted diffusion. Approach: Extended range, with b-values from 0 10000 and two echo times, allowing for NNLS decomposition of spectra T2 mapping. Results: Restricted characterised. Impact: Possibly relevant cell migration associated changes in the extracellular matrix.
Background Given that changes in brain water content are often correlated with disease, investigating non‐invasively and vivo could lead to a better understanding of the pathogenesis several neurologic diseases. Purpose To adapt super‐resolution‐based technique, previously developed for humans, rat report high‐resolution (HR) maps comparison ex wet/dry methods. Study Type Prospective. Animal Model Eight healthy male Wistar rats. Field Strength/Sequence 9.4‐T, multi‐echo gradient‐echo (mGRE)...
The propagation of water molecules in the brain and corresponding NMR response are affected by many factors such as compartmentalization, restrictions anisotropy imposed cellular microstructure. Interfacial interactions with cell membranes exchange additionally come into play. Due to complexity underlying factors, a differentiation between various contributions average signal vivo studies represents difficult task. In this work we perform random‐walk Monte Carlo simulations well‐defined...
<p>QRAGE is a novel imaging sequence and reconstruction method for the simultaneous mapping of multiple quantitative MRI parameters, including water content, T1, T2*, magnetic susceptibility at ultrahigh field strength. QRAGE employs ME-MPnRAGE that acquires 171 contrast images different inversion echo time points, enabling accurate precise parameter estimation. It further incorporates model-based method, MIRAGE2, leverages prior knowledge temporal signal evolution represented as...
<p>QRAGE is a novel imaging sequence and reconstruction method for the simultaneous mapping of multiple quantitative MRI parameters, including water content, T1, T2*, magnetic susceptibility at ultrahigh field strength. QRAGE employs ME-MPnRAGE that acquires 171 contrast images different inversion echo time points, enabling accurate precise parameter estimation. It further incorporates model-based method, MIRAGE2, leverages prior knowledge temporal signal evolution represented as...
<p>QRAGE is a novel imaging sequence and reconstruction method for the simultaneous mapping of multiple quantitative MRI parameters, including water content, T1, T2*, magnetic susceptibility at ultrahigh field strength. QRAGE employs ME-MPnRAGE that acquires 171 contrast images different inversion echo time points, enabling accurate precise parameter estimation. It further incorporates model-based method, MIRAGE2, leverages prior knowledge temporal signal evolution represented as...