P.K. Malhotra
A5103121736- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- High-Energy Particle Collisions Research
- Dark Matter and Cosmic Phenomena
- Neutrino Physics Research
- Nuclear physics research studies
- Particle Detector Development and Performance
- Drug Transport and Resistance Mechanisms
- Cholesterol and Lipid Metabolism
- Epigenetics and DNA Methylation
- Astrophysics and Cosmic Phenomena
- Protein Structure and Dynamics
- Enzyme Structure and Function
- Nuclear Physics and Applications
- Graphite, nuclear technology, radiation studies
- Digestive system and related health
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Helicobacter pylori-related gastroenterology studies
- Pediatric Hepatobiliary Diseases and Treatments
- Radiation Therapy and Dosimetry
- Pancreatic function and diabetes
- Peroxisome Proliferator-Activated Receptors
- X-ray Spectroscopy and Fluorescence Analysis
Washington State University
2023-2025
Saint Michael's Medical Center
2023
New York Medical College
2023
Post Graduate Institute of Medical Education and Research
2010-2022
Tata Institute of Fundamental Research
1989-2021
University of Illinois Chicago
2011-2021
National Centre for Biological Sciences
2011-2021
ESIC Hospital
2020
Jesse Brown VA Medical Center
2011-2019
Lehigh University
2017
Bile acids modulate several gastrointestinal functions including electrolyte secretion and absorption, gastric emptying, small intestinal colonic motility. High concentrations of bile lead to diarrhea are implicated in the development esophageal, cancer. Alterations acid homeostasis also pathophysiology irritable bowel syndrome (IBS) inflammatory disease (IBD). Our understanding mechanisms underlying these effects on gut has been greatly enhanced by discovery receptors, nuclear receptors:...
The production of the Jψ resonance in 125-GeV/c p¯ and φ− interactions with Be, Cu, W targets has been measured. cross section per nucleon for is suppressed relative to lighter targets, especially at large values Feynman x, which opposite expectation from various explanations European Muon Collaboration effect. Models incorporating modifications gluon structure functions heavy show qualitative agreement data.Received 14 December 1987DOI:https://doi.org/10.1103/PhysRevLett.60.2121©1988...
We report on a study of the inclusive production properties D¯D mesons in pp collisions at 800 GeV/c and compare our results to measurements made lower energies expectations QCD fusion model.Received 1 August 1988DOI:https://doi.org/10.1103/PhysRevLett.61.2185©1988 American Physical Society
The incidence of colorectal cancer (CRC) is increasing rapidly in Asian countries during the past few decades, but no comprehensive analysis has been done to find out exact cause this disease. In study, we investigated frequencies mutations and expression pattern K-ras, APC (adenomatosis polyposis coli) p53 tumor, adjoining distant normal mucosa correlate these alterations with patients clinicopathological parameters as well survival. Polymerase chain reaction (PCR)-restriction digestion was...
Abstract Background Complicated urinary tract infections (cUTI) often involve multidrug-resistant uropathogens requiring treatment with intravenous (IV) antibiotics (ABX); risk of IV-line complications increases longer duration. We studied the occurrence and impact in patients cUTI other treated IV ABX for < 30 days. Methods A systematic literature search was conducted MEDLINE Embase, supplemented by conference, bibliography, keyword-based searches (2013–2023). Additional on bacterial...
Curcumin, the major phenolic compound in spice turmeric, exhibits numerous biological effects, including lowering plasma cholesterol and preventing diet-induced hypercholesterolemia. The mechanisms underlying hypocholesterolemic effect of curcumin are not fully understood. In this regard, intestinal Niemann-Pick C1-like 1 (NPC1L1) transporter, molecular target absorption inhibitor ezetimibe, plays an essential role maintenance homeostasis. current studies were designed to investigate on...
The elastic differential scattering cross sections, as well inelastic have been obtained for both ${\ensuremath{\pi}}^{+}$ and ${\ensuremath{\pi}}^{\ensuremath{-}}$ on ${\mathrm{He}}^{4}$ at 129, 140, 150 $\frac{\mathrm{MeV}}{c}$, using a 50-cm helium bubble chamber. Following the suggestion of Sternheim Hofstadter, we analyzed these data in order to obtain Coulomb-nuclear interference term. From this, Coulomb amplitude is deduced, which gives information pion charge distribution. are terms...
Sterol Response Element Binding Protein 2 (SREBP2) transcription factor is a master regulator of cholesterol homeostasis. Treatment with statins, inhibitors synthesis, activates intestinal SREBP2, which may hinder their cholesterol-lowering effects. Overactivation SREBP2 in mouse liver was shown to have no effect on plasma cholesterol. However, the influence activating not known. We generated novel transgenic model intestine specific overexpression active (ISR2) driven by villin promoter....
The serotonin (5-HT) transporter (SERT) facilitates clearance of extracellular 5-HT by its uptake and internalization. Decreased expression SERT consequent high levels have been implicated in various diarrheal disorders. Thus, appropriate regulation is critical for maintenance homeostasis health disease. Previous studies demonstrated that regulated via posttranslational transcriptional mechanisms. However, the role epigenetic mechanisms not known. Current investigated effects histone...