Sarah O’Leary

ORCID: 0000-0003-1874-5994
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About
Contact & Profiles
Research Areas
  • Mosquito-borne diseases and control
  • CRISPR and Genetic Engineering
  • Insect Resistance and Genetics
  • Insect symbiosis and bacterial influences
  • Genetics, Bioinformatics, and Biomedical Research
  • Marine and coastal ecosystems
  • Biomedical and Engineering Education
  • Bacterial Genetics and Biotechnology
  • Child Development and Digital Technology
  • Plant Pathogenic Bacteria Studies
  • Fish Ecology and Management Studies
  • Antibiotic Resistance in Bacteria
  • Media Influence and Health
  • Aquatic Ecosystems and Phytoplankton Dynamics
  • Effects and risks of endocrine disrupting chemicals
  • Air Quality and Health Impacts
  • Child and Adolescent Psychosocial and Emotional Development
  • Viral Infectious Diseases and Gene Expression in Insects
  • Toxic Organic Pollutants Impact

University of Limerick
2022

Texas A&M University
2019-2021

Rutgers, The State University of New Jersey
2020

University of Nottingham
1997

Members of two genera Gram‐negative bacteria, Serratia and Erwinia , produce a β‐lactam antibiotic, 1‐carbapen‐2‐em‐3‐carboxylic acid. We have reported previously the cloning sequencing genes responsible for production this carbapenem in carotovora . These are organized as an operon, carA–H controlled by LuxR‐type transcriptional activator, encoded linked carR gene. report paper genetic dissection putative operon to determine function each genes. demonstrate mutational analysis that products...

10.1046/j.1365-2958.1997.6001974.x article EN Molecular Microbiology 1997-10-01

Aedes aegypti is a vector of dengue, chikungunya, and Zika viruses. Current control strategies such as community engagement, source reduction, insecticides have not been sufficient to prevent viral outbreaks. Thus, interest in novel involving genetic engineering growing. Female mosquitoes rely on flight mate with males obtain bloodmeal from host. We hypothesized that knockout genes specifically expressed female associated the indirect muscles would result flightless mosquito. Using...

10.1371/journal.pntd.0008971 article EN cc-by PLoS neglected tropical diseases 2020-12-18

Abstract Increased usage of organophosphate flame retardants (OPFRs) has led to detectable levels in pregnant women and neonates, which is associated with negative neurological outcomes. Therefore, we investigated if maternal OPFR exposure altered adult offspring feeding, locomotor, anxiety‐like behaviors on a low‐fat (LFD) or high‐fat diet (HFD). Wild‐type C57Bl/6J dams were orally dosed vehicle (sesame oil) an mixture (1 mg/kg combination each tris(1,3‐dichloro‐2‐propyl)phosphate,...

10.1002/jat.4056 article EN publisher-specific-oa Journal of Applied Toxicology 2020-10-14

Abstract Aedes aegypti is a vector of dengue, chikungunya, and Zika viruses. Current control strategies such as community engagement, source reduction, insecticides have not been sufficient to prevent viral outbreaks. Thus, interest in novel involving genetic engineering growing. Female mosquitoes rely on flight mate with males obtain bloodmeal from host. We hypothesized that knockout genes specifically expressed female associated the indirect muscles would result flightless mosquito. With...

10.1101/862300 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2019-12-02

Mosquito gene editing has become routine in several laboratories with the establishment of systems such as transcription-activator-like effector nucleases (TALENs), zinc-finger (ZFNs), and homing endonucleases (HEs). More recently, clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) technology offered an easier cheaper alternative for precision genome engineering. Following nuclease action, DNA repair pathways will fix broken ends, often...

10.3791/63008 article EN Journal of Visualized Experiments 2021-09-10

Mosquito gene editing has become routine in several laboratories with the establishment of systems such as transcription-activator-like effector nucleases (TALENs), zinc-finger (ZFNs), and homing endonucleases (HEs). More recently, clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) technology offered an easier cheaper alternative for precision genome engineering. Following nuclease action, DNA repair pathways will fix broken ends, often...

10.3791/63008-v article EN Journal of Visualized Experiments 2021-09-10
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