A5044331573- Inflammatory Bowel Disease
- Gut microbiota and health
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Digestive system and related health
- Health Systems, Economic Evaluations, Quality of Life
- Glycosylation and Glycoproteins Research
- Celiac Disease Research and Management
- Drug Transport and Resistance Mechanisms
- Clinical Nutrition and Gastroenterology
- Microscopic Colitis
- Biosimilars and Bioanalytical Methods
- Tuberculosis Research and Epidemiology
- Helicobacter pylori-related gastroenterology studies
- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
Ajinomoto (Japan)
2012-2015
Ajinomoto (United States)
2014
Keio University
2012-2013
Summary Bile acids ( BA s) play important roles not only in lipid metabolism, but also signal transduction. TGR 5, a transmembrane receptor of s, is an immunomodulative factor, its detailed mechanism remains unclear. Here, we aimed to delineate how s operate immunological responses via the 5 pathway human mononuclear cell lineages. We examined expression peripheral blood monocytes, several types vitro differentiated macrophages (Mϕs) and dendritic cells. Mϕs with macrophage...
Background Inflammatory bowel disease (IBD) is a chronic intestinal disorder that associated with limited number of clinical biomarkers. In order to facilitate the diagnosis IBD and assess its activity, we investigated potential novel multivariate indexes using statistical modeling plasma amino acid concentrations (aminogram). Methodology Principal Findings We measured fasting aminograms in 387 patients (Crohn's (CD), n = 165; ulcerative colitis (UC), 222) 210 healthy controls. Based on...
<h3>Background</h3> Chronic inflammation characterised by IgG-producing plasma cell infiltration of colonic mucosa is a histological hallmark ulcerative colitis (UC); however, whether its function pathogenic or protective remains unclear. <h3>Objective</h3> To explore the contribution intestinal IgG cells to UC pathogenesis. <h3>Methods</h3> We isolated lamina propria mononuclear (LPMCs) from patients and analysed characteristics (expression profiles differentiation molecules chemokine...
Ulcerative colitis (UC) is characterized by chronic intestinal inflammation. Patients with UC have repeated remission and relapse. Clinical biomarkers that can predict relapse in patients not been identified. To facilitate the prediction of UC, we investigated potential novel multivariate indexes using statistical modeling plasma free amino acid (PFAA) concentrations. We measured fasting PFAA concentrations 369 clinical remission, 355 were observed prospectively for up to 1 year. Relapse...
In Crohn's disease (CD), the involvement of food antigens in immune responses remains unclear. The objective this study was to detect against CD patients and examine mechanism a mouse model colitis.We enrolled 98 patients, 50 ulcerative colitis 52 healthy controls (HCs) compare levels serum immunoglobulin (Ig)Gs 88 foods. presence IgGs foods also examined interleukin (IL)-10 knockout (KO) mice which CD4(+) T cell activation by antigenic protein assessed. Mice transferred with IL-10 KO cells...
Introduction: Ulcerative colitis (UC) is characterized by chronic intestinal inflammation. Patients with UC have repeated remission and relapse. Very few number of clinical biomarkers can predict relapse in patients remission. To facilitate the prediction UC, we investigated potential novel multivariate indexes using statistical modeling plasma free amino acid (PFAA) concentrations. We measured fasting PFAA concentrations 369 remission, 355 were observed prospectively for up to 1 year....