Phyllanthus niruri L. is a widespread tropical plant which used in Ayurvedic system for liver and kidney ailments. The present study aims at specifying the most active hepatoprotective extract of P. applying bio-guided protocol to identify compounds responsible this effect. aerial parts were extracted separately with water, 50%, 70% 80% ethanol. cytoprotective activity extracts was evaluated against CCl4-induced hepatotoxicity clone-9 Hepg2 cells. Bioassay-guided fractionation aqueous (AE)...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the latest arisen contagious pathogen related to global outbreak of atypical pneumonia pandemic (COVID-19). The essential oils (EOs) Eucalyptus camaldulensis, E. ficifolia F. Muell., citriodora Hook, globulus Labill, sideroxylon Cunn. ex Woolls, and torquata Luehm. were investigated for its antiviral activity against SARS-CoV-2. EOs phytochemical composition was determined using GC/MS analysis. Correlation with explored also...

Gouty arthritis is one of the most common metabolic disorders affecting people. Plant based drugs can lower risk this health disorder. The anti-gouty potential Eucalyptus torquata flowers methanol extract (ETME) was evaluated in vitro via measuring inhibitory effects five pro-inflammatory enzymes; xanthine oxidase (XO), hyaluronidase, lipoxygenase (5-LOX), cyclooxygenases COX-1, and COX-2, addition to evaluating inhibition histamine release, albumin denaturation, membrane stabilization,...

The development of multidrug-resistant bacterial strains is a worldwide emerging problem that needs global solution. Exploring new natural antibiofilm agents one the most important alternative therapies in combating infections. This study aimed at testing antimicrobial potential Eucalyptus sideroxylon flowers extract (ESFE) against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans prior to activity S. P. C. albicans. ESFE demonstrated...

The development of new natural drugs for Helicobacter pylori (H. pylori) management has recently received significant attention. Iris confusa (I. confusa) was long used the treatment bacterial infections and gastritis. This study aimed at evaluating its effect on H. infection exploring bioactive metabolites. inhibitory potential polar (PF), non-polar (NPF) fractions isolated compounds against using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay in addition to...

Multidrug-resistant bacterial species and their untreatable infections threaten human health worldwide. The four seasons' essential oils (EOs) of Operculicarya decaryi were investigated against methicillin resistant Staphylococcus aureus MRSA. Limonene was the major component identified in O. EOs followed by methyl cinnamate. autumn oil (Odao) has a robust antibacterial effect Camphor, carvone, p-cymen-7-ol, α-terpinen-7-al, cryptone, caryophyllene oxide highly correlated to observed...

Hibiscus species (Malvaceae) have been long used as an antihypertensive folk remedy. The aim of our study was to specify the optimum solvent for extraction angiotensin-converting enzyme inhibiting (ACEI) constituents from sabdariffa L. 80% methanol extract (H2) showed highest ACEI activity, which exceeds that standard captopril (IC50 0.01255 ± 0.00343 and 0.210 0.005 µg/mL, respectively). Additionally, in a comprehensive metabolomics approach, ultra-performance liquid chromatography (UPLC)...

Natural medicines formulated using nanotechnology-based systems are a rich source of new wound-treating therapeutics. This study aims to develop thymol-loaded cationic polymeric nanoparticles (CPNPs) enhance the skin retention and wound healing efficacy thymol. The developed materials exhibited entrapment efficiencies 56.58 68.97%, particle sizes 36.30 99.41 nm, positively charged zeta potential. In Vitro sustained release thymol up 24 h was achieved. Selected CPNPs (F5 C2) were mixed with...

(1) Background: Bacterial resistance to antibiotics is a global life-threatening issue. Antivirulence therapy promising approach combat bacterial infections as it disarms the bacteria from their virulence factors with reduced selective pressure and lower chance of resistance. (2) Methods: Callistemon citrinus leaf extract its major constituent, Pulverulentone A, were tested for ability inhibit biofilm, exopolysaccharides, pyocyanin proteases produced by MDR P. aeruginosa. In addition,...

Abstract Carissa species are evergreen plants that have long been employed in treating different diseases by traditional healers many cultures. macrocarpa (Eckl.) A. DC. known as Natal plum is characterized bright red, edible, plum-shaped fruit tastes like cranberries. The pharmacological studies on validated its use indigenous medicine systems. evidence-based modulatory potential of C. aerial parts (leaves and stems) non-communicable hepato-protective activity herein evaluated via testing...

The hydrodistilled essential oil content of Origanum majorana L. (Lamiaceae) ranged from 2.5-3% with the maximal value (3%) in spring. Analysis by GC/MS resulted identification 15, 11, and 14 components oils prepared spring, summer, autumn, winter, respectively. composition differed quantitatively qualitatively according to time collection. Thymol (38.4%) cis-sabinene hydrate (25.3%) were major spring plants. Terpinen-4-ol (37.4%, 20.5%, 16.3%) was a component autumn winter oils,...

Eurycoma longifolia Jack (Fam.: Simaroubaceae), known as Tongkat Ali (TA), has been a symbol of virility and sexual power for men. Metabolic profiling the aqueous extract E. (AEEL) using UPLC-MS/MS in both positive negative modes allowed identification seventeen metabolites. The identified compounds were classified into four groups: quassinoids, alkaloids, triterpenes, biphenylneolignans. AEEL is considered safe with oral LD50 cut-off >5000 mg/kg. Oral administration 50, 100, 200, 400, or...

Eurycoma longifolia Jack is one of traditional herbal medicines in South-East Asia. This study evaluated the anticancer, cell-cycle arrest, and apoptotic induction potentials eurycomanone (EONE) eurycomanol (EOL), highly oxygenated quassinoids previously isolated from its roots, against large (H460) small (A549) lung cancer cells. EOL EONE exhibited IC50 386 424 µg/mL on normal human cell line. higher anticancer activity with an 1.78 20.66 μg/mL than which 3.22 38.05 H460 A549, respectively....

Pseudomonas aeruginosa is a repertoire of several virulence factors that create frightening high pathogenicity level as well antimicrobial resistance toward commercially used antibiotics. Therefore, finding new alternative to traditional antimicrobials must. Resveratrol very famous phytochemical harbors many beneficial health properties by possessing antibacterial, anti-inflammatory, and antioxidant properties. The current study aimed explore the efficacy resveratrol against P. its ability...

Eucalyptus barks contain complex biomass of constituents with considerable chemical and structural diversity. Reports about sideroxylon Cunn. ex Woolls bark composition biological activities are limited. Non-targeted metabolomic analysis via ultra-performance liquid chromatography-quadrupole-time-of-flight-photodiode array-mass spectrometry (UPLC-qTOF-PDA-MS) enabled first-time detection 41 secondary metabolites which 31 were identified including; 6 flavonoids, 4 ellagic acid derivatives, 8...

Gymnocarpos decandrus Forssk. is a well-known grazing wild plant. This study targets scientific validation of its claimed antidiabetic activity and exploring bioactive metabolites. Chromatographic purification G. ethanol extract (GDEE) allowed isolation vitexin (C1), protocatechuic acid (C2) quercetin (C3). HPLC-PDA-MS/MS enabled identification nineteen metabolites; 13 flavonoids, 5 saponins, 1 phenolic in four the genus for first time. The potential was evaluated via testing Coxsackie B4...

Background. Eurycoma longifolia Jack (Fam.: Simaroubaceae), known as Tongkat Ali (TA), has been a symbol of virility and sexual power. The aim the study was to screen E. aqueous extract (AE) isolates for ROCK-II inhibition. Results. AE (1-10 μg/ml) showed significant inhibition activity (62.8-81%) at P < 0.001 with an IC50 (651.1 ± 32.9 ng/ml) compared Y-27632 ([(+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride]) (68.15-89.9 %) same concentrations (192 8.37...