A5053913922- Endometrial and Cervical Cancer Treatments
- Genetic factors in colorectal cancer
- Ovarian cancer diagnosis and treatment
- Sarcoma Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- Cancer-related molecular mechanisms research
- Multiple and Secondary Primary Cancers
- Colorectal and Anal Carcinomas
- Breast Cancer Treatment Studies
- Colorectal Cancer Treatments and Studies
- Occupational and environmental lung diseases
- Healthcare cost, quality, practices
- Acute Myocardial Infarction Research
- Autopsy Techniques and Outcomes
- Nonmelanoma Skin Cancer Studies
- RNA Research and Splicing
- Testicular diseases and treatments
- Breast Lesions and Carcinomas
- Chromatin Remodeling and Cancer
- Cancer Diagnosis and Treatment
- Genital Health and Disease
- Cutaneous Melanoma Detection and Management
University of Hawaiʻi at Mānoa
2012-2022
Okayama Saiseikai General Hospital
2021
Queen's Medical Center
2006-2020
Yokohama City University
2010-2018
University of Hawaii System
2004-2018
Kitasato University Hospital
2018
University Pathologists
2017
Queens Hospital Center
2013
Sunagawa City Medical Center
2013
Yokohama City University Medical Center
2010
// Michele Carbone 1 , David Shimizu 2 Andrea Napolitano Mika Tanji Harvey I. Pass 3 Haining Yang Sandra Pastorino Thoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, HI, USA Department Pathology, Queen Medical Cardiothoracic Surgery, New York University, NYU Langone NY, Correspondence to: Carbone, email: mcarbone@cc.hawaii.edu Keywords: mesothelioma, lung cancer, BAP1, differential diagnosis, immunohistochemistry Received: May 20, 2016 Accepted: June 13, Published: July...
Between 1995 and 1999, we observed an increasing number of nodes being recovered from colorectal specimens. Patients with cancer were studied to determine whether the negative would better stage patient more accurately predict disease-free survival.All patients undergoing resection curative intent between 1999 at a tertiary referral hospital retrospectively reviewed. Tumor stage, grade, recovered, association these factors survival was analyzed.Three hundred forty-five M0 disease surgical...
ObjectivesTo determine the impact of implementing p16 Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions (LAST) guidelines, we compared use and follow-up data before after implementation guidelines.
The ribonuclease ranpirnase (Onconase) has been used empirically to treat malignant mesothelioma (MM) patients, and some of them had prolonged survivals. aim this study was investigate the mechanisms therapeutic function in MM cells. effects were studied vivo vitro on 2 cell lines (epithelioid REN sarcomatoid PPM-Mill). We found that able inhibit NF-κB nuclear translocation, evaluated by fractionation immunoblotting as well immunofluorescence. Also, MMP9 secretion cells decreased treatment,...
The benefit of evaluating the precursor endometrial carcinoma, hyperplasia (intraepithelial neoplasia [EIN]), for loss mismatch repair (MMR) protein expression and Lynch syndrome has yet to be determined. present study aims establish incidence type MMR in unselected premalignant lesions adenocarcinoma, as well agreement immunohistochemical staining pretreatment biopsy (EMB) specimens with subsequent uterine resections.A retrospective review identified 112 biopsies meeting criteria EIN....
The aim of this study was to determine the histopathologic characteristics patients with endometrial carcinoma low-volume metastases (micrometastases and isolated tumor cells) compared macrometastases.We performed a retrospective review carcinoma.Among 350 robotic-assisted hysterectomies for cancer, 187 (53%) underwent attempted sentinel lymph node (SLN) biopsy. At least 1 SLN detected in 185, 99% overall detection rate; 108 (58%) also had non-SLNs removed. Among 91 SLNs from ipsilateral...
Patients diagnosed with an endometrial cancer precursor lesion on biopsy may be found to have at the time of subsequent surgery. The current study seeks identify patients intraepithelial neoplasia (EIN) that harboring occult carcinoma. Immunohistochemical stains for gene loss expression (LOE) 6 genes, PTEN, ARID1A, MSH6, MSH2, MLH1, and PMS2, were performed 113 specimens EIN. For 95 follow-up histology, 40 had cancer, 41 EIN, 14 normal endometrium. PTEN LOE was frequently in both EIN...
We report a case of axillary metaplastic breast carcinoma (MBC) with triple negative (ER-/PR-/Her2-) phenotype, concurrent multifocal invasive ductal (IDC) ipsilateral pectoral (ER+/PR+/Her2-) in 60-year-old woman. The two tumors demonstrate different morphology, immunophenotype, and opposite response to neoadjuvant chemotherapy paclitaxol, adriamycin, cyclophosphamide. Methylation analysis human androgen receptor (HUMARA) on X-chromosome identified monoclonal pattern inactivation MBC mosaic...
To determine characteristic features of myocardial infarction (MI) diagnosed at autopsy and establish the incidence discrepancy.Autopsy cases a tertiary hospital with pathologic diagnosis acute MI were evaluated for clinicopathologic features. Modified Goldman's classification was used to classify discrepant cases.Of 529 cases, 19 (3.6%) demonstrated acute/subacute as diagnosis. Thrombosis identified in minority (3/19, 15.8%). Major discrepancies four (21.1%) cases.Although is an uncommon...
Placental site trophoblastic tumor (PSTT) is a rare form of gestational neoplasia (GTN). It most commonly occurs after delivery but may arise any type pregnancy. PSTT arises neoplastic transformation intermediate cells. The reported symptoms are abnormal bleeding or amenorrhea. Due to the rarity this disease, evidence on prognostic factors as well optimal treatment limited. While for early-stage disease usually limited surgery, multimodal with chemotherapy and surgery be important metastatic...
In a biopsy specimen, adenocarcinomas of the endometrium and uterine cervix may demonstrate significant morphologic overlap. The distinction between these two entities prior to surgical resection is clinically as assigning primary site dictates treatment prognosis. This diagnostic dilemma approached by application panel immunohistochemical stains, traditionally composed CEA, vimentin, p16, ER, PR. Most cases are successfully managed with this panel; however, in difficult additional tools...
e17073 Background: ARID1a is thought to function as a tumor suppressor; mutations in this gene have been associated with many cancers. Recent studies found atypical endometriosis well ovarian carcinomas. Methods: The current study retrospective review of 91 cases clear cell and endometrioid carcinomas diagnosed at Queens Medical Center Honolulu, Hawaii between Janurary 1, 1995 April 12, 2013. Tissue microarray was performed evaluate loss expression ARID1a. Loss confirmed on whole slide...
Tailgut cysts, also known as retrorectal cystic hamartomas and mucus-secreting are rare benign congenital lesions that thought to be derived from remnants of the embryonic postanal gut, which incompletely regresses during development.They composed uni-or multilocular cysts lined by a variety epithelia, occur mostly in middle-aged women at 3:1 female-tomale ratio with reported incidence 1/40,000-63,000 admissions large referral centers.Complications tailgut include infection, inflammation,...