A5089533371- Nerve injury and regeneration
- Congenital Anomalies and Fetal Surgery
- Neurogenetic and Muscular Disorders Research
- RNA modifications and cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Neuroscience and Neuropharmacology Research
- Cerebral Palsy and Movement Disorders
- Stroke Rehabilitation and Recovery
- Balance, Gait, and Falls Prevention
Johns Hopkins Medicine
2019-2023
Johns Hopkins University
2019-2023
Abstract Intercellular communication between axons and Schwann cells is critical for attaining the complex morphological steps necessary axon maturation. In early onset motor neuron disease spinal muscular atrophy (SMA), many are not ensheathed by nor grow sufficiently in radial diameter to become myelinated. These developmentally arrested dysfunctional vulnerable rapid degeneration, limiting efficacy of current SMA therapeutics. We hypothesized that accelerating maturation would improve...
Accumulating evidence and medical guidelines recommend high-dose neurorehabilitation for recovery after stroke. Unfortunately, most patients receive a fraction of this dose, with therapist availability costs delivery being major implementational barriers. To explore potential solution, we conducted retrospective analysis real-world enhanced clinical service that used gamified self-training technologies at home under remote supervision. Data from 17 who completed 12-18 week full-body, program...
Abstract Serotonin axons in the adult rodent brain can regrow and recover their function following several forms of injury including controlled cortical impact (CCI), a neocortical stab wound, or systemic amphetamine toxicity. To assess whether this capacity for regrowth is unique to serotonergic fibers, we used CCI models fibers from other neuromodulatory systems also injury. Using tyrosine-hydoxylase (TH) immunohistochemistry measured density catecholaminergic before at various time points...