A5053886902- Neurogenetic and Muscular Disorders Research
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- RNA Research and Splicing
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Cancer-related molecular mechanisms research
- Eosinophilic Esophagitis
- Gut microbiota and health
- Marine Bivalve and Aquaculture Studies
- Head and Neck Cancer Studies
- Muscle Physiology and Disorders
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Galectins and Cancer Biology
- Breast Cancer Treatment Studies
- Ubiquitin and proteasome pathways
- Advanced Radiotherapy Techniques
- Congenital Anomalies and Fetal Surgery
- Radiomics and Machine Learning in Medical Imaging
- Protease and Inhibitor Mechanisms
- Cancer-related gene regulation
Johns Hopkins University
2010-2025
Johns Hopkins Medicine
2009-2025
Shandong Tumor Hospital
2012-2025
Shandong First Medical University
2012-2025
Guangdong Provincial Academy of Environmental Science
2025
Ocean University of China
2019-2024
Binzhou University
2010-2024
Binzhou Medical University
2011-2024
Qingdao University
2017-2024
Affiliated Hospital of Qingdao University
2017-2024
The motor neuron disease spinal muscular atrophy (SMA) causes profound muscle weakness that most often leads to early death. At autopsy, SMA is characterized by loss of neurons and atrophy, but the initial cellular events precipitate unit dysfunction remain poorly characterized. Here, we examined function corresponding structure neuromuscular junction (NMJ) synapses in a mouse model severe (hSMN2/delta7SMN/mSmn−/−). Surprisingly, NMJs remained innervated even late course; however they showed...
The inherited motor neuron disease spinal muscular atrophy (SMA) is caused by deficient expression of survival (SMN) protein and results in severe muscle weakness. In SMA mice, synaptic dysfunction both neuromuscular junctions (NMJs) central sensorimotor synapses precedes cell death. To address whether this due to SMN deficiency neurons, muscle, or both, we generated three lines conditional mice with tissue-specific increases expression. All showed increased survival, weights, improved...
Early treatment with the histone deacetylase inhibitor, trichostatin A, plus nutritional support extended median survival of spinal muscular atrophy mice by 170%. Treated continued to gain weight, maintained stable motor function, and retained intact neuromuscular junctions long after A was discontinued. In many cases, ultimate decline appeared result from vascular necrosis, raising possibility that dysfunction is part clinical spectrum severe atrophy. disease detection initiation combined...
Gene replacement and pre-mRNA splicing modifier therapies represent breakthrough gene targeting treatments for the neuromuscular disease spinal muscular atrophy (SMA), but mechanisms underlying variable efficacy of treatment are incompletely understood. Our examination severe infantile onset human SMA tissues obtained at expedited autopsy revealed persistence developmentally immature motor neuron axons, many which actively degenerating. We identified similar features in a mouse model SMA,...
Safe and effective prophylactic therapies for radiation-induced dermatitis (RID) remain an unmet need.To determine if epigallocatechin-3-gallate (EGCG) solution reduces the incidence of RID in patients undergoing radiotherapy after breast cancer surgery.This phase 2 double-blind, placebo-controlled randomized clinical trial enrolled 180 with receiving postoperative at Shandong Cancer Hospital Institute Shandong, China, between November 2014 June 2019. Data analysis was performed from...
ObjectiveThis study explored the potential association between Prognostic Nutritional Index (PNI) and incidence of non-alcoholic fatty liver disease (NAFLD) advanced fibrosis (AF) in adult population United States.MethodsInformation on 6409 participants ≥18 years old was downloaded from U.S. National Health Nutrition Examination Survey (NHANES) 2017 to 2020. Multivariate analysis combined with demographic factors assess relationships PNI, NAFLD, AF. A restricted cubic spline (RCS) used...
Blood-CNS barrier disruption is a hallmark of numerous neurological disorders, yet whether breakdown sufficient to trigger neurodegenerative disease remains unresolved. Therapeutic strategies mitigate hyperpermeability are also limited. Dominant missense mutations the cation channel transient receptor potential vanilloid 4 (TRPV4) cause forms hereditary motor neuron disease. To gain insights into cellular basis these we generated knock-in mouse models TRPV4 channelopathy by introducing two...
Spinal muscular atrophy (SMA) is an inherited motor neuron disease caused by the mutation of survival 1 (SMN1) gene and deficiency SMN protein. Severe SMA mice have abnormal function small, immature myofibers early in development suggesting that protein results retarded muscle growth. Insulin-like growth factor (IGF-1) stimulates myoblast proliferation, induces myogenic differentiation generates myocyte hypertrophy vitro vivo. We hypothesized increased expression IGF-1 specifically skeletal...
The purpose of this study was to investigate the safety, tolerability and preliminary effectiveness topical epigallocatechin-3-gallate (EGCG) for radiation dermatitis in patients with breast cancer receiving adjuvant radiotherapy.Patients who received radiotherapy chest wall after mastectomy were enrolled. EGCG solution sprayed field from initiation Grade 1 until 2 weeks completion radiotherapy. concentration escalated 40 660 μmol l(-1) 7 levels 3-6 each level. toxicity graded using NCI...
Podoplanin, lymphatic vessel endothelial hyaluronic acid receptor-1, prospero-related homeobox-1 and vascular growth factor receptor 3 have been demonstrated to crucial roles in the development of system lymphangiogenesis process by combining with their corresponding receptors. Thus, four markers widely used labelling vessels for detection invasion. Numerous authors aimed identify these mechanisms partly clarified at molecular level. The aim present review was comprehensively clarify...
In the inherited childhood neuromuscular disease spinal muscular atrophy (SMA), lower motor neuron death and severe muscle weakness result from reduction of ubiquitously expressed protein survival (SMN). Although SMA mice recapitulate many features human disease, it has remained unclear if their short lifespan are primarily due to cell-autonomous defects in neurons. Using Hb9(Cre) as a driver, we selectively raised SMN expression neurons conditional SMAΔ7 mice. Unlike previous study that...
Purpose To investigate whether the apparent diffusion coefficient (ADC) values acquired from diffusion‐weighted magnetic resonance imaging (DW‐MRI) are correlated with molecular markers Ki‐67, hypoxia‐inducible factor 1α (HIF‐1α), and vascular endothelial growth (VEGF) in rectal cancer (RC). Materials Methods Ninety‐one patients (64 males 27 females) diagnosed underwent 3.0T DW‐MRI before any anticancer treatment. was performed using single‐shot echo‐planar technique (b = 0 b 800 s/mm 2 )....
Mangrove ecosystems are important in tropical and subtropical coastal zones, contributing to marine biodiversity maintaining ecological balance. It is cru-cial develop more efficient, intelligent, accurate monitoring methods for mangroves understand better protect mangrove ecosystems. This study promoted a novel model, MangroveNet, integrating multi-scale spectral spatial information de-tecting area. In addition, we also presented an improved model—AttCloudNet+ identify distribution of...
Objectives: This meta-analysis of randomized controlled trials was conducted to give a more precise estimation the efficacy and drawbacks total gastrectomy (TG) versus subtotal (SG) for proven distal gastric cancer. Methods: The electronic databases Cochrane PubMed (updated on April 10, 2016) were searched comparing TG with SG as surgical procedures Five outcome variables analyzed, including postoperative complications, anastomotic fistula rate, hospital mortality rate recurrence (the...
Acute radiation-induced esophagitis (ARIE) is among the most serious form of toxicities associated with definitive radiotherapy or chemoradiotherapy used for treatment patients esophageal cancer. Our preliminary phase I and II trials lung cancer who received indicated epigallocatechin-3-gallate (EGCG) as a promising therapeutic option against ARIE. Therefore, we conducted prospective study to validate efficacy safety EGCG in The Shandong Cancer Hospital Institute China were enrolled present...
There is a significant unmet need in treating patients with limited-stage small-cell lung cancer (LS-SCLC). The ETER701 study showed that Benmelstobart (TQB2450, an anti-PD-L1 antibody) combined Anlotinib and chemotherapy achieved the longest progression-free survival (PFS) overall (OS) as first-line therapy extensive-stage small cell (ES-SCLC). This suggests TQB2450 represent promising treatment combination for LS-SCLC. prospective aimed to evaluate efficacy safety of maintenance LS-SCLC...