A5064535920- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Lung Cancer Diagnosis and Treatment
- Speech and Audio Processing
- Cancer Mechanisms and Therapy
- Medical Imaging Techniques and Applications
- HVDC Systems and Fault Protection
- Esophageal Cancer Research and Treatment
- High-Voltage Power Transmission Systems
- Nuclear Physics and Applications
- Immunotherapy and Immune Responses
- Radiopharmaceutical Chemistry and Applications
- Radiation Therapy and Dosimetry
- Combustion and Detonation Processes
- Brain Metastases and Treatment
- Lightning and Electromagnetic Phenomena
- Speech Recognition and Synthesis
- Neuroscience and Neuropharmacology Research
- Glioma Diagnosis and Treatment
- Nuclear physics research studies
- Capital Investment and Risk Analysis
- Ocular Oncology and Treatments
- Advanced Optical Sensing Technologies
Shandong First Medical University
2016-2025
Shandong Tumor Hospital
2016-2025
Shandong University
2016-2025
Suzhou Municipal Hospital
2023-2024
Nanjing Medical University
2019-2024
Chengdu University of Technology
2023
State Key Laboratory of Geohazard Prevention and Geoenvironment Protection
2023
Soochow University
2017-2023
First Affiliated Hospital of Soochow University
2017-2023
China Institute of Atomic Energy
2023
Abstract Background The antiviral drug Nirmatrelvir was found to be a key in controlling the progression of pneumonia during infectious phase COVID-19. However, there are very few options for effective treatment cancer patients who have viral pneumonia. Glucocorticoids is one means control pneumonia, but many adverse events. EGCG natural low toxic compound with anti-inflammatory function. Thus, this study designed investigate safety and efficacy epigallocatechin-3-gallate (EGCG) aerosol...
N-Methyl-d-aspartate (NMDA) receptors, a subtype of ionotropic glutamate receptors in the central nervous system (CNS), have garnered attention for their role brain disorders. Specifically, GluN2A-containing NMDA emerged as potential therapeutic target treatment depressive disorders and epilepsy. However, development receptor-selective antagonists, represented by N-(4-(2-benzoylhydrazine-1-carbonyl)benzyl)-3-chloro-4-fluorobenzenesulfonamide (TCN-201) its derivatives, faces significant...
Osimertinib combined with chest radiotherapy has a high incidence of pneumonia, dacomitinib is widely used in clinical practice, but there are no studies reporting the pulmonary safety combinating radiotherapy. Here we report case radiation pneumonitis occurring by and thoracic (TRT). The patient was 55-year-old woman lung adenocarcinoma. She had received surgery adjuvant chemotherapy. presented bilateral intramammary para-aortic metastatic lymphadenopathy, which confirmed as metastasis,...
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Abstract Blockade of the T cell immunoreceptor with immunoglobulin and tyrosine-based inhibitory motif domain (TIGIT) can enhance innate adaptive tumor immunity radiotherapy (RT) anti-tumor immunity. However, our data suggest that TIGIT-mediated immune suppression may be an impediment to such goals. Herein, we report on synergistic effects RT combined anti-TIGIT therapy mechanism their interaction. Treatment efficacy was assessed by measuring primary secondary growth, survival, memory...
There is a significant unmet need in treating patients with limited-stage small-cell lung cancer (LS-SCLC). The ETER701 study showed that Benmelstobart (TQB2450, an anti-PD-L1 antibody) combined Anlotinib and chemotherapy achieved the longest progression-free survival (PFS) overall (OS) as first-line therapy extensive-stage small cell (ES-SCLC). This suggests TQB2450 represent promising treatment combination for LS-SCLC. prospective aimed to evaluate efficacy safety of maintenance LS-SCLC...
The R‑spondin (RSPO) family of secreted proteins consists four members that have critical roles in embryonic development and organogenesis. However, the expression patterns exact individual RSPO tumorigenesis progression lung cancer are unknown, particularly non‑small cell cancer, which accounts for 85% all cases. In present study, data from ONCOMINE database was used to compare RNA levels RSPOs multiple different types with normal controls. profiles various lines were subsequently compared...
Local tumor recurrence is one of the main causes for failure esophageal cancer treatment following radiotherapy. Previous studies have demonstrated that epidermal growth factor receptor (EGFR)‑targeted therapy combined with radiotherapy expected to become an effective means control recurrence. The aim present study was investigate effect and mechanism nimotuzumab (an EGFR‑targeted antibody) in recurrent carcinoma. radiation responses two squamous carcinoma cell lines, EC109 TE‑1, or without...
Objectives: The aim was to define the role of chemotherapy in stage II nasopharyngeal carcinoma (NPC) and identify toxicity for these patients era intensity-modulated radiotherapy (IMRT). Methods: Between January 2002 December 2013, 169 with NPC were analyzed. Of patients, 149 treated divided into three groups as follows: neoadjuvant followed by IMRT (NCT) group, concurrent (CCRT) CCRT (NC+CCRT) group. In addition, 20 received alone. We retrospectively assessed 10-year survival acute adverse...
The pathogenesis of pulmonary arterial hypertension (PAH) is closely linked to the abnormal proliferation artery smooth muscle cells. Studies have demonstrated that microRNAs play pivotal roles in progression hypertension. We found microRNA-637 (miR-637) and microRNA-661 (miR-661) are expressed at low levels serum PAH patients. Moreover, overexpression miR-637 or miR-661 inhibited human cell (HPASMC) migration hypoxic culture. Mechanistically, we overexpressed these two HPASMCs,...
TGFB induced factor homeobox 1 (TGIF1), a transcriptional corepressor, has been reported to be involved in tumorigenesis and cancer development. However, the role of TGIF1 growth metastasis esophageal is poorly studied. In present study, it was found that highly expressed tissues cell lines. The silencing by siRNA interference significantly inhibited proliferation, migration, invasion epithelial‑mesenchymal transition (EMT) process KYSE‑150 cells, promoted apoptosis. Correspondingly,...
PVC and balsa wood are usually used in the interlayer structures of wind turbine blades. In this paper, a comparative study on lightning damage characteristics two materials was carried out by molecular dynamic simulations impact current experiments. The show that glycosidic bonds cellulose break first, which leads to strong decrease degree polymerization (DP) (while DP changes irregularly), then C−O pyranoid ring main chain is destroyed, producing small molecule fractions lot gas molecules....
The net present value (NPV) rule is not the only criterion available to evaluate a capital investment proposal.You may be familiar with payback period, internal rate of return, or another criterion.This paper examines and explains how apply NPV rule: internal-rate-of-return (IRR) rule, criteria used by large sample companies when making budgeting decisions, IRR rules being most popular average accounting return PI least popular.We analyze whether satisfy conditions good decision rule.Recall...
The current highest glacial lake outburst floods (GLOFs) risk level is centered in the eastern Himalaya. GLOFs represent a serious threat to downstream inhabitants and ecological environment. In context of climate warming on Tibetan Plateau, such will continue or even intensify future. Remote sensing statistical methods are often used diagnose lakes with probability. These efficient large-scale assessment but do not take into consideration complexity specific dynamics triggering factor...
To evaluate the effects of dexmedetomidine (DEX) on outcomes critically ill patients with acute kidney injury (AKI).Data were extracted from Medical Information Mart for Intensive Care III database (MIMIC III). Propensity score matching (PSM) analysis (1 : 3), Cox proportional hazards model, linear regression and logistic model used to assess effect DEX clinical outcomes.After PSM, 324 pairs matched between administration those without. was associated decreased in-hospital mortality (hazard...