A5001181407- Laser-Matter Interactions and Applications
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Advanced Chemical Physics Studies
- Spectroscopy and Quantum Chemical Studies
- Mass Spectrometry Techniques and Applications
- Atomic and Molecular Physics
- Laser-induced spectroscopy and plasma
- Strong Light-Matter Interactions
- Esophageal and GI Pathology
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Plasmonic and Surface Plasmon Research
- RNA modifications and cancer
- Thermal Radiation and Cooling Technologies
- Pleural and Pulmonary Diseases
- Esophageal Cancer Research and Treatment
- CAR-T cell therapy research
- Wastewater Treatment and Nitrogen Removal
- Medical Imaging and Pathology Studies
- Cancer, Hypoxia, and Metabolism
- Cold Atom Physics and Bose-Einstein Condensates
Zhongshan Hospital
2016-2025
Fudan University
2016-2025
Shandong First Medical University
2019-2024
Shandong Tumor Hospital
2019-2024
East China Normal University
2017-2024
Shenzhen Children's Hospital
2024
Harbin Institute of Technology
2022-2024
Academy of Medical Sciences
2023
The First Affiliated Hospital, Sun Yat-sen University
2016-2022
Sun Yat-sen University
2016-2022
Background: Lung adenocarcinoma (LUAD), the major subtype of lung cancer, is among leading cause cancer-related death worldwide.Energy-related metabolic reprogramming metabolism a hallmark cancer shared by numerous types, including LUAD.Nevertheless, functional pathways and molecular mechanism which FAM83A-AS1 acts in have not been fully elucidated.Methods: We used transwell, wound-healing scratch assay, assays to explore effect LUAD cell lines.Western blotting, Co-IP assays, ubiquitination...
Exciton polaritons have shown great potential for applications such as low-threshold lasing, quantum simulation, and dissipation-free circuits. In this paper, we realize a room temperature ultrafast polaritonic switch where the Bose-Einstein condensate population can be depleted at hundred femtosecond timescale with high extinction ratios. This is achieved by applying an ultrashort optical control pulse, inducing parametric scattering within photon part of polariton via four-wave mixing...
Abstract Background Tissue-resident memory T (T RM ) cells can reside in the tumor microenvironment and are considered primary response to immunotherapy. Heterogeneity functional status spatial distribution may contribute controversial role of but we know little about it. Methods Through multiplex immunofluorescence (mIF) (CD8, CD103, PD-1, Tim-3, GZMB, CK), quantity location cell subsets were recognized tissue from 274 patients with NSCLC after radical surgery. By integrating multiple...
Visceral pleural invasion (VPI) is considered a poor prognostic factor in non-small cell lung cancer (NSCLC). We aimed to analyze the effect of VPI on cancer-specific survival, using propensity score matching (PSM) based Surveillance, Epidemiology, and End Results database.We identified 9901 patients with T1-2N0-2M0 who received segmentectomy, lobectomy, or pneumonectomy. Ten covariates were included PSM. The survival was assessed, stratified by nodal status tumor size.One-thousand...
Abstract Background Anti-PD-(L)1 immunotherapy has been recommended for non-small cell lung cancer (NSCLC) patients with lymph node metastases (LNM). However, the exact functional feature and spatial architecture of tumor-infiltrating CD8 + T cells remain unclear in these patients. Methods Tissue microarrays (TMAs) from 279 IA-IIIB NSCLC samples were stained by multiplex immunofluorescence (mIF) 11 markers (CD8, CD103, PD-1, Tim3, GZMB, CD4, Foxp3, CD31, αSMA, Hif-1α, pan-CK). We evaluated...
We experimentally visualize the dissociative frustrated double ionization of hydrogen molecules by using few-cycle laser pulses in a pump-probe scheme, which process tunneling ionized electron is recaptured one outgoing nuclei breaking molecule. Three internuclear distances are recognized to enhance at different instants after first step. The recapture can be further steered as desired phase-controlled two-color pulses. Both experimental measurements and numerical simulations suggest that...
Abstract Atoms and molecules exposed to strong laser fields can be excited the Rydberg states with very high principal quantum numbers large orbitals. It allows acceleration of neutral particles, generate near-threshold harmonics, reveal multiphoton Rabi oscillations rich photoelectron spectra. However, physical mechanism state excitation in is yet a puzzle. Here, we identify electron-nuclear correlated as general by coincidently measuring all charged fragments ejected from H 2 molecule....
We developed and validated novel radiomics-based nomograms to identify epidermal growth factor receptor (EGFR) mutations the Ki-67 proliferation index of non-small cell lung cancer.We enrolled 132 patients with histologically verified cancer from four hospital institutions who underwent computed tomography (CT) scans. EGFR were measured tumor tissues. A total 1,287 radiomic features extracted, a three-stage feature selection method was implemented acquire most valuable features. Finally,...
Whispering gallery modes in a microwire are characterized by nearly equidistant energy spectrum. In the strong exciton-photon coupling regime, this system represents bosonic cascade: ladder of discrete levels that sustains stimulated transitions between neighboring steps. Here, using femtosecond angle-resolved spectroscopic imaging technique, ultrafast dynamics polaritons cascade based on one-dimensional ZnO whispering microcavity explicitly visualized. Clear ladder-form build-up processes...
Rotational dynamics of D_{2} molecules inside helium nanodroplets is induced by a moderately intense femtosecond pump pulse and measured as function time recording the yield HeD^{+} ions, created through strong-field dissociative ionization with delayed probe pulse. The oscillates period 185 fs, reflecting field-free rotational wave packet dynamics, oscillation persists for more than 500 periods. Within experimental uncertainty, constant B_{He} in-droplet molecule, determined Fourier...
Alignment and orientation of molecules by intense, ultrashort laser fields are crucial for a variety applications in physics chemistry. These include control high harmonics generation, molecular orbitals tomography, photoionization dissociation processes, production "molecular movies" with the help X-ray free-electron sources ultrafast electron diffraction relativistic electrons. While dynamics laser-induced alignment has been extensively studied demonstrated, is much more challenging task,...
Although immunotherapy has achieved great clinical success in outcomes, especially the anti-PD-1 or anti-PD-L1 antibodies, not all patients respond to immunotherapy. It is urgently required for a diagnosis develop non-invasive imaging meditated strategy assessing expression level of PD-L1 tumors. In this work, 68Ga-labeled single-domain antibody tracer, 68Ga-NOTA-Nb109, was designed specific and noninvasive an MC38 tumor-bearing mouse model. Comprehensive studies including Positron Emission...
Background The anti-tumoral or pro-tumoral roles of CD4 + and CD8 T cells typify the complexity cell subsets function in cancer. In non-small lung cancer (NSCLC), density topology distinct phenotypes at tumor center (TC) versus invasive margin (IM) are largely unknown. Here, we investigated distribution within TC IM regions NSCLC its impact on prognosis. Methods We performed multiplex immunofluorescence using a tissue microarray samples from 99 patients with locally advanced to elucidate...
Background DNA methylation aberration and microRNA (miRNA) deregulation have been observed in many types of cancers. A systematic study methylome transcriptome bladder urothelial carcinoma has never reported. Methodology/Principal Findings The was profiled by modified methylation-specific digital karyotyping (MMSDK) the expression mRNAs miRNAs analyzed gene (DGE) sequencing tumors matched normal adjacent tissues obtained from 9 patients. We found that a set significantly enriched pathways...
Abstract Background The computed tomography (CT) characteristic of ground glass opacity (GGO) were shown to be associated with clinical significance in lung adenocarcinoma. We evaluated the prognostic value solid component ratio GGO IA invasive Methods retrospectively analyzed records patients who received surgical resection from April 2012 December 2015. was calculated based on thin-slice CT scans. Baseline features compared stratified by ratio. Cox proportional hazard models and survival...
Abstract Nanoplasmas induced by intense laser fields have attracted enormous attention due to their accompanied spectacular physical phenomena which are vigorously expected the community of science and industry. For instance, energetic electrons ions produced in laser-driven nanoplasmas significant for development compact beam sources. Nevertheless, effective confinement on propagating charged particles, was realized through magnetic field modulation target structure design big facilities,...