Due to the recent introduction of new biologic drugs for chronic migraine, a global evaluation in real clinical practice is necessary.The objective was evaluate effectiveness and safety targeting calcitonin gene-related peptide receptor (CGRPr) patients with migraine.Single-center, restrospective study (2019-2022), including migraine treated erenumab, galcanezumab, or fremanezumab. Effectiveness variables were recorded, namely, number headache days per month (MHD), Migraine Disability...

The alteration of the gut microbiota mediated by proton pump inhibitor (PPI) drugs could be involved in clinical response associated with immunotherapy [immunocheckpoint inhibitors (ICIs)] cancer patients. Due to current controversy scientific evidence, it has been proposed evaluate correlation between concomitant use PPIs and effectiveness a real practice setting. Single-center retrospective cohort study that included patients treated anti-PD-1 or anti-CTLA4, including nivolumab,...

<h3>Background and importance</h3> Recently, the GEMINIS I II studies have demonstrated how lamivudine (3TC) with dolutegravir (DTG) bitherapy in naive patients is as effective conventional triple therapy after 48 weeks of follow-up.¹ <h3>Aim objectives</h3> To analyse 5 year economic impact treatment HIV from perspective hospital management a third level <h3>Material methods</h3> A mathematical model Excel format was designed to estimate difference costs between DTG/3TC regimens...

<h3>Background and importance</h3> Prolonged treatment with tocilizumab has been associated cases of severe hepatotoxicity liver failure hepatitis, characterised by elevated hepatic transaminases (GOT/AST GPT/ALT). <h3>Aim objectives</h3> To analyse the incidence elevation enzymes presence damage in patients treated tocilizumab, a third level hospital. <h3>Material methods</h3> A descriptive, observational, 10 year study that included all for more than 6 months, from January 2009 to August...

<h3>Background and importance</h3> Regorafenib (REG) trifluridine–tipiracil (TAS-102) are used in metastatic colorectal cancer (mCRC) after failure of conventional therapy based on fluorouracil (5-FU) schemes. <h3>Aim objectives</h3> To evaluate the efficacy safety TAS-102 regorafenib drugs patients with mCRC. <h3>Material methods</h3> A retrospective single centre study was conducted from January 2010 to August 2020, which included all diagnosed CRBM treated TAS-102/REG. Clinical...

To determine the rate of microbiological confirmation in diagnosis Pneumocystis jirovecii pneumonia patients treated with intravenous pentamidine and potential correlation treatment effectiveness safety.Single-centre retrospective study (2010-2020), which included those who received for at least 48 hours. The sample collection procedure analysis performed were recorded. Efficacy was determined by 14-day mortality admission to Intensive Care Unit (ICU), disease control length hospital stay...

<h3>Background</h3> The HR +HER2 subtype is the most common molecular profile in women with breast cancer and appearance of this new group drugs has drastically changed prognosis patients. <h3>Purpose</h3> To describe safety Palbociclib Ribociclib two third-level hospitals. <h3>Material methods</h3> A multicentre, retrospective, 39 month study (May 2015 to August 2018), which we analysed all patients treated or Ribociclib. following variables were collected: age treatment onset, metastatic...

<h3>Background</h3> The use of immunotherapy in the oncological environment has meant a revolution management this pathology. Its effectiveness is based on activating patient's immune system through various mechanisms action. A good safety profile makes its attractive to oncologists, but there are patients whom toxicities relevance can appear. <h3>Purpose</h3> To describe toxicity developed by some type been administered for treatment their neoplastic process tertiary hospital <h3>Material...

<h3>Background and importance</h3> Therapeutic growth in the arsenal of drugs for treatment severe asthma (SA) with similar efficacy profiles, safety mechanisms action requires multidisciplinary protocols to maintain sustainability health systems. The last therapeutic positioning report, published January 2019, found that choice between benralizumab, reslizumab or mepolizumab patients SA eosinophilia should be based on efficiency criteria. In addition, when is mediated by IgE eosinophilia,...

<h3>Background and importance</h3> Therapy for inflammatory bowel disease (IBD) has included ustekinumab vedolizumab in cases where antitumour necrosis factor-alpha (TNFα) drugs or conventional therapy failed. Currently, both constitute a high economic impact at the hospital level. <h3>Aim objectives</h3> This was cost minimisation analysis between IBD to determine third level hospital. <h3>Material methods</h3> A 2 year, unicentre, retrospective study (January 2017–December 2019) carried...

<h3>Background and importance</h3> Enzalutamide (ENZ) abiraterone (AA) are two drugs that have been shown to improve survival in patients diagnosed with metastatic castration resistant prostate cancer (CRPCm). There no direct comparison studies of these drugs, so comparative analyses may help therapeutic positioning. <h3>Aim objectives</h3> To evaluate the response both measured as an early decrease specific antigen (PSA) levels, CRPCm patients. <h3>Material methods</h3> A prospective study...

<h3>Background and importance</h3> Analysis of data obtained in the 'real world' setting is acquiring great importance healthcare environment. It important to know results with different treatments outside ideal environment offered by clinical trials. <h3>Aim objectives</h3> To describe analyse infliximab (IFX) over a 10 year period patients diagnosed ulcerative colitis (UC). <h3>Material methods</h3> This was retrospective descriptive study conducted third level hospital that included all...

<h3>Background and importance</h3> One of the new advances in oncology patient care will be based on continuous control adverse reactions derived from use antineoplastic treatments identification early progression disease these patients by means what are known as PROs (results reported patients). <h3>Aim objectives</h3> The application this system requires Web-2.0 skills patient. Thus objective study was to determine perception for future implementation a digital platform communication our...