A5067000131- Blood Pressure and Hypertension Studies
- Health Systems, Economic Evaluations, Quality of Life
- Bone health and osteoporosis research
- Hip and Femur Fractures
- Radiomics and Machine Learning in Medical Imaging
- Sodium Intake and Health
- Bone health and treatments
- CAR-T cell therapy research
- Hormonal Regulation and Hypertension
- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical studies and practices
- Atrial Fibrillation Management and Outcomes
- Integrated Circuits and Semiconductor Failure Analysis
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrhythmias and Treatments
- Molecular Biology Techniques and Applications
- Epilepsy research and treatment
- Alcohol Consumption and Health Effects
- Chronic Kidney Disease and Diabetes
- Fetal and Pediatric Neurological Disorders
- SARS-CoV-2 and COVID-19 Research
- Cardiac Health and Mental Health
- Periodontal Regeneration and Treatments
- Pharmaceutical Economics and Policy
- Acute Kidney Injury Research
Navarre Institute of Health Research
2015-2025
Universidad Publica de Navarra
2024-2025
Servicio Navarro de Salud
2003-2024
Madrid Health Service
2022
University of British Columbia
2021
Cochrane
2021
Centro de Investigación Biomédica en Red
2018
Universitat Pompeu Fabra
2018
Parc de Salut
2018
In 2020, prior to COVID-19 vaccine rollout, the Brighton Collaboration created a priority list, endorsed by World Health Organization, of potential adverse events relevant vaccines. We adapted list evaluate serious special interest observed in mRNA trials.
Despite widespread endorsement, <b>Teppo Järvinen and colleagues</b> argue that evidence for stratifying risk of fracture subsequent drug therapy to prevent hip is insufficient warrant our current approach
Objectives To evaluate the association between bisphosphonate use and risk of atypical femoral fractures among women aged 65 or older. Design Nested case–control study. Setting General practice research database in Spain. Exposures Use oral bisphosphonates before occurrence cases corresponding index date controls. Bisphosphonate was categorised as ever versus never users. Ever users were divided according to total time since first prescription. Main outcome measures Cases defined years older...
Aims To evaluate the association between use of different oral antidiabetic agents (OAD) and risk community‐acquired pneumonia (CAP) in patients with type‐2 diabetes (T2DM). Methods Case–control study nested a cohort T2DM OAD 2002 2013, based Spanish general practice research database. Cases were people diagnosed T2DM, aged >18 years validated diagnosis CAP 2013. Ten controls matched on age, sex calendar year. Odds ratio (OR) was estimated comparing treated with: (1) metformin vs. other...
Abstract Cochrane's scientific strategy for 2025 to 2030 has four research priorities, including improving the lives of people living with multiple chronic conditions. The purpose this article written by Cochrane Thematic Group in Heart, Stroke and Circulation is explore considerations around conditions (also referred as ‘multiple long‐term conditions’ i.e. two or more conditions) systematic reviews. Rather than using term ‘comorbidity’, we introduce a new ‘co‐long‐term conditions’. We also...
Objective The FOURIER trial showed a benefit of the PCSK9 inhibitor evolocumab over placebo with respect to cardiovascular outcomes in patients disease. However, we observed some inconsistencies between information Clinical Study Report (CSR) and that 2017 primary results publication. We aimed restore mortality data based on contained death narratives CSR. Methods Mortality publication were compared In cases discrepancy sources, an independent committee blindly readjudicated restored cause...
To evaluate the association between long-term use of bisphosphonates and risk hip fracture compared to never among women aged 65 years or older.Case-control study nested in a cohort.General practice research database operated by Spanish Medicines Agency.Cases were defined as older with validated first diagnosis 2005 2008. Five controls free matched on age calendar-year each case.Information bisphosphonate use, fractures, comedication comorbidities was collected.Hip comparing users versus...
When covid-19 vaccines were first authorised, regulators required post-authorisation studies to tackle important uncertainties about efficacy and safety. But these may have little practical value unless there is greater engagement scrutiny from the wider scientific community, argue <b>Christof Prugger colleagues</b>
<ns4:p>Objective To determine the efficacy and safety of CAR-T therapy in treatment patients with hematologic malignancies, comparison other current therapies. Design A living systematic review Methods We will include randomized trials evaluating effect versus active treatments, hematopoietic stem cell transplantation, best supportive care or any intervention malignancies. Non-randomized primary studies be searched case we found no direct evidence from controlled trials. Two reviewers...
A randomized clinical trial assessing plasma rich in growth factors (PRGF) versus hyaluronic acid for knee osteoarthritis was published 2012 (sponsor ID BTI-01-EC/07/ART). Evidence of misreporting discovered following access to unpublished materials. In accordance with the principles Restoring Invisible and Abandoned Trials (RIAT) initiative, we sought re-analyse Study PRGF based on materials.Reanalysis made possible primarily two study documents (original protocol final report) obtained...