A5047931135- Proteoglycans and glycosaminoglycans research
- Prostate Cancer Treatment and Research
- Glycosylation and Glycoproteins Research
- RNA Interference and Gene Delivery
- Radiopharmaceutical Chemistry and Applications
- Boron Compounds in Chemistry
- Cell death mechanisms and regulation
- Extracellular vesicles in disease
- Malaria Research and Control
- Mass Spectrometry Techniques and Applications
- Phytoestrogen effects and research
- Nuclear Materials and Properties
- Cancer Immunotherapy and Biomarkers
- Advanced Battery Materials and Technologies
- HIV Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Peroxisome Proliferator-Activated Receptors
- Multiple Myeloma Research and Treatments
- Nuclear Structure and Function
- Nuclear Physics and Applications
- Lipid Membrane Structure and Behavior
- Advanced Battery Technologies Research
- Immune Cell Function and Interaction
- Urinary and Genital Oncology Studies
University of British Columbia
2014-2022
LEO Foundation
2022
University of Copenhagen
2022
The Ohio State University
1989
Abstract Muscle-invasive bladder cancer (MIBC) is an aggressive disease with limited therapeutic options. Although immunotherapies are approved for MIBC, the majority of patients fail to respond, suggesting existence complementary immune evasion mechanisms. Here, we report that PPARγ/RXRα pathway constitutes a tumor-intrinsic mechanism underlying in MIBC. Recurrent mutations RXRα at serine 427 (S427F/Y), through conformational activation heterodimer, and focal amplification/overexpression...
ZBP1 is an interferon-induced cytosolic nucleic acid sensor that facilitates antiviral responses via RIPK3. Although ZBP1-mediated programmed cell death widely described, whether and how it promotes inflammatory signaling unclear. Here, we report a ZBP1-induced pathway mediated by K63- M1-linked ubiquitin chains, which depends on RIPK1 RIPK3 as scaffolds independently of death. In human HT29 cells, associated with well ligases cIAP1 LUBAC. ubiquitination to promote TAK1- IKK-mediated...
Clusterin (CLU) is a stress-activated molecular chaperone that confers treatment resistance to taxanes when highly expressed. While CLU inhibition potentiates activity of and other anti-cancer therapies in preclinical models, progression treatment-resistant disease still occurs implicating additional compensatory survival mechanisms. Taxanes are believed selectively target cells mitosis, complex mechanism controlled part by balancing antagonistic roles Cdc25C Wee1 mitosis progression. Our...
Abstract Lineage plasticity of prostate cancer is associated with resistance to androgen receptor (AR) pathway inhibition (ARPI) and supported by a reactive tumor microenvironment. Here we show that changes in chondroitin sulfate (CS), major glycosaminoglycan component the cell glycocalyx extracellular matrix, AR-regulated promotes adaptive progression castration-resistant (CRPC) after ARPI. AR directly represses transcription 4- O -sulfotransferase gene CHST11 under basal conditions,...
Abstract Proteoglycans are proteins that modified with glycosaminoglycan chains. Chondroitin sulfate proteoglycans (CSPGs) currently being exploited as targets for drug-delivery in various cancer indications, however basic knowledge on how CSPGs internalized tumor cells is lacking. In this study we took advantage of a recombinant CSPG-binding lectin VAR2CSA (rVAR2) to track internalization and cell fate cells. We found rVAR2 into via multiple mechanisms after initial docking surface CSPGs....
Abstract Increased levels of chondroitin sulfate (CS) glycosaminoglycans (GAGs) in prostate cancer (PC) have been observed for more than three decades. In 1984, De Klerk et al. noted that hyperplastic and cancerous contained elevated CS while other GAGs, like heparin (HS), were decreased. Chondroitin sulfate-modified proteoglycans (CSPGs), such as versican or tomoregulin (TENB2), promoted PC progression markers. They associated with cell attachment to the matrix, metastatic phenotype,...
Abstract Proteoglycans are proteins that modified with glycosaminoglycan chains. Chondroitin sulfate proteoglycans (CSPGs) currently being exploited as targets for drug-delivery in various cancer indications, however basic knowledge on how CSPGs internalized tumor cells is lacking. In this study we took advantage of a recombinant CSPG-binding lectin VAR2CSA (rVAR2) to track internalization and cell fate cells. We found rVAR2 into via multiple mechanisms after initial docking surface CSPGs....